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Plasma orexin-A level associated with physical activity in obese people

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Objective

To measure the amount of physical activity (PA) among obese adults, investigate the association between plasma orexin-A level and PA patterns, and explore the effect of orexin on the prevention and control of obesity.

Methods

Interviews were conducted in 218 participants (106 obese; 73 overweight; and 39 normal) who ranged in age between 18 and 70 years using a survey that included sociodemographic variables. The International Physical Activity Questionnaire (IPAQ-long version) was used to measure PA. A total of 178 participants agreed to submit blood sample collections, and plasma orexin-A content was measured by ELISA testing.

Results

The average level of orexin-A was 85.34 ± 42.85 ng/L in the obese group, 97.38 ± 36.72 ng/L in the overweight group, and 106.56 ± 52.09 ng/L in the control group, which was significantly different (P = 0.03). The concentration of plasma orexin-A correlated with the total PA (P = 0.000), moderate PA (obese = 0.007; overweight: P = 0.000; control: P = 0.000), and walking PA (P = 0.000) in all three groups. Working and domestic PAs were significantly associated with the plasma orexin-A level (P < 0.0001).

Conclusions

The plasma orexin-A level was associated with PA in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.

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References

  1. Li XY, Jiang Y, Hu N, Li YC, Zhang M, Huang ZJ, Zhao WH (2012) Prevalence and characteristic of overweight and obesity among adults in China, 2010. Zhonghua Yu Fang Yi Xue Za Zhi 46(8):683–686. doi:10.1371/journal.pone.0098744

    Article  CAS  PubMed  Google Scholar 

  2. Joibari MM, Khazali H (2013) Effect of stress on fasting-induced ghrelin, orexin and galanin secretion in male rats fed different levels of their energy requirement. Obesity 21(1):130–134. doi:10.1038/oby.2012.185

    Article  CAS  PubMed  Google Scholar 

  3. Mavanji V, Perez-Leighton CE, Kotz CM, Billington CJ, Parthasarathy S, Sinton CM, Teske JA (2015) Promotion of wakefulness and energy expenditure by orexin A in the ventrolateral preoptic area. Sleep. doi:10.5665/sleep.4970

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92(4):573–585. doi:10.1016/S0092-8674(00)80949-6

    Article  CAS  Google Scholar 

  5. Nixon JP, Smale L (2007) A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents. Behav Brain Funct 3(1):28. doi:10.1186/1744-9081-3-28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30(2):345–354. doi:10.1016/S0896-6273(01)00293-8

    Article  CAS  PubMed  Google Scholar 

  7. Papathanasiou G, Zerva E, Zacharis I, Papandreou M, Papageorgiou E, Tzima C, Georgakopoulos D, Evangelou A (2015) Association of high blood pressure with body mass index, smoking and physical activity in healthy young adults. Open Cardiovasc Med J 9:5–17. doi:10.2174/1874192401509010005

    Article  PubMed  PubMed Central  Google Scholar 

  8. Qn N, Lk J (2004) Study on the reliability validity of international physical activity questionnaire (Chinese vision, IPAQ). Chin J Epidemiol 25(3):265–268. doi:10.3760/j.issn:0254-6450.2004.03.021

    Article  Google Scholar 

  9. Buhmann H, le Roux CW, Bueter M (2014) The gut-brain axis in obesity. Best Pract Res Clin Gastroenterol 28(4):559–571. doi:10.1016/j.bpg.2014.07.003

    Article  CAS  PubMed  Google Scholar 

  10. Feder ME, Garland T Jr, Marden JH, Zera AJ (2010) Locomotion in response to shifting climate zones: not so fast. Annu Rev Physiol 72:167–190. doi:10.1146/annurev-physiol-021909-135804

    Article  CAS  PubMed  Google Scholar 

  11. Novak CM, Levine JA (2009) Daily intraparaventricular orexin-A treatment induces weight loss in rats. Obesity 17(8):1493–1498. doi:10.1038/oby.2009.91

    Article  CAS  PubMed  Google Scholar 

  12. Teske JA, Perez-Leighton CE, Billington CJ, Kotz CM (2013) Role of the locus coeruleus in enhanced orexin A-induced spontaneous physical activity in obesity-resistant rats. Am J Physiol-Reg I 305(11):R1337–R1345. doi:10.1152/ajpregu.00229.2013

    Article  CAS  Google Scholar 

  13. Bergstrom G, Behre C, Schmidt C (2012) Increased leisure-time physical activity is associated with lower prevalence of the metabolic syndrome in 64-year old women with impaired glucose tolerance. Angiology 63(4):297–301. doi:10.1177/0003319711414867

    Article  PubMed  Google Scholar 

  14. Mundi MS, Lorentz PA, Swain J, Grothe K, Collazo-Clavell M (2013) Moderate physical activity as predictor of weight loss after bariatric surgery. Obes Surg 23(10):1645–1649. doi:10.1007/s11695-013-0979-y

    Article  PubMed  Google Scholar 

  15. Yu S, Guo X, Yang H, Zheng L, Sun Y (2015) Metabolic syndrome in hypertensive adults from rural Northeast China: an update. BMC Publ Health 15:247. doi:10.1186/s12889-015-1587-7

    Article  CAS  Google Scholar 

  16. Pardo A, Roman-Vinas B, Ribas-Barba L, Roure E, Vallbona C, Serra-Majem L (2014) Health-enhancing physical activity and associated factors in a Spanish population. J Sci Med Sport/Sports Med Aust 17(2):188–194. doi:10.1016/j.jsams.2013.04.002

    Article  Google Scholar 

  17. Samir N, Mahmud S, Khuwaja AK (2011) Prevalence of physical inactivity and barriers to physical activity among obese attendants at a community health-care center in Karachi, Pakistan. BMC Res Notes 4:174. doi:10.1186/1756-0500-4-174

    Article  PubMed  PubMed Central  Google Scholar 

  18. Ying Z, Ning LD, Xin L (2015) Relationship between built environment, physical activity, adiposity, and health in adults aged 46–80 in Shanghai, China. J Phys Act Health 12(4):569–578. doi:10.1123/jpah.2013-0126

    Article  PubMed  Google Scholar 

  19. Shaikh RA, Sikora A, Siahpush M, Singh GK (2015) Occupational variations in obesity, smoking, heavy drinking, and non-adherence to physical activity recommendations: findings from the 2010 National Health Interview Survey. Am J Ind Med 58(1):77–87. doi:10.1002/ajim.22405

    Article  PubMed  Google Scholar 

  20. Cigdem Arica P, Kocael A, Tabak O, Taskin M, Zengin K, Uzun H (2013) Plasma ghrelin, leptin, and orexin-A levels and insulin resistance after laparoscopic gastric band applications in morbidly obese patients. Minerva Med 104(3):309–316

    CAS  PubMed  Google Scholar 

  21. Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW (2002) Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord: J Int Assoc Study Obes 26(2):274–276. doi:10.1038/sj.ijo.0801868

    Article  CAS  Google Scholar 

  22. Baranowska B, Wolinska-Witort E, Martynska L, Chmielowska M, Baranowska-Bik A (2005) Plasma orexin A, orexin B, leptin, neuropeptide Y (NPY) and insulin in obese women. Neuro Endocrinol Lett 26(4):293–296

    CAS  PubMed  Google Scholar 

  23. Hamilton MT, Healy GN, Dunstan DW, Zderic TW, Owen N (2008) Too little exercise and too much sitting: inactivity physiology and the need for new recommendations on sedentary behavior. Curr Cardiovasc Risk Rep 2(4):292–298. doi:10.1007/s12170-008-0054-8

    Article  PubMed  PubMed Central  Google Scholar 

  24. Kotz CM, Wang C, Teske JA, Thorpe AJ, Novak CM, Kiwaki K, Levine JA (2006) Orexin A mediation of time spent moving in rats: neural mechanisms. Neuroscience 142(1):29–36. doi:10.1016/j.neuroscience.2006.05.028

    Article  CAS  PubMed  Google Scholar 

  25. Randy R, Yves VA, Ilse DB (2003) Addressing overreporting on the International Physical Activity Questionnaire (IPAQ) telephone survey with a population sample. Publ Health Nutr 6(3):299–305

    Google Scholar 

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Acknowledgments

We thank the Chinese medicine integrated with Western medicine Lab for supporting the experimental techniques. This study was supported by the Natural Science Foundation of China (Grant number: 81173392).

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Authors and Affiliations

  1. School of Medicine, Yangzhou University, Huaihai Road, Yangzhou, Zip code: 225000, Jiangsu, The People’s Republic of China

    Yuan-yuan Hao, Hong-wang Yuan, Peng-hua Fang, Yu Zhang, Yue-xia Liao, Ting-ting Zhang & Ping Bo

  2. Pediatric Cardiothoracic Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People’s Republic of China

    Chen Shen

  3. Colorectal Surgical Department of Jiangsu Province Hospital, Nanjing, Jiangsu, The People’s Republic of China

    Dan Wang

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  1. Yuan-yuan Hao
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Correspondence to Ping Bo.

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Funding

National Natural Science Foundation of China (No. 81173392).

Conflict of interest

The authors declare that there is no conflict of interests regarding the publication of this article.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the committee of School of Medicine of Yangzhou University and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from the patient included in the case report.

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Hao, Yy., Yuan, Hw., Fang, Ph. et al. Plasma orexin-A level associated with physical activity in obese people. Eat Weight Disord 22, 69–77 (2017). https://doi.org/10.1007/s40519-016-0271-y

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  • DOI: https://doi.org/10.1007/s40519-016-0271-y

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