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Intestinal and Extra-Intestinal Manifestations of Campylobacter in the Immunocompromised Host

  • Bacterial Infections (H Bach, Section Editor)
  • Published:
Current Treatment Options in Infectious Diseases Aims and scope Submit manuscript

Abstract

Purpose of review

Describe most recent data on manifestations and treatment of intestinal and extra-intestinal manifestations of Campylobacter among immunocompromised patients.

Recent findings

Resistance to fluoroquinolones, macrolides, and tetracycline challenge traditional empiric therapies.

Summary

Recurrent Campylobacter enteritis and bacteremia are associated with hypogammaglobinemia, HIV, transplant-associated immunotherapy, and hematologic malignancies. C. jejuni and C. coli are the most commonly associated Campylobacter species although C. fetus, C. upsaliensis, C. lari, C. curvus, and C. rectus should be considered as potential causative agents of rare extra-intestinal infections. Successful diagnosis and treatment of these cases may require the recognition of the limits of standard diagnostics and the recent emergence of highly resistant strains of Campylobacter, particularly C. coli.

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References and Recommended Reading

  1. Tack DM, Marder EP, Griffin PM, Cieslak PR, Dunn J, Hurd S, et al. Preliminary incidence and trends of infections with pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2015–2018. MMWR Morb Mortal Wkly Rep. 2019;68(16):369–73.

    PubMed  PubMed Central  Google Scholar 

  2. Kotloff KL, Platts-Mills JA, Nasrin D, Roose A, Blackwelder WC, Levine MM. Global burden of diarrheal diseases among children in developing countries: Incidence, etiology, and insights from new molecular diagnostic techniques. Vaccine 2017;35(49 Pt A):6783–6789.

  3. Platts-Mills JA, Liu J, Rogawski ET, Kabir F, Lertsethtakarn P, Siguas M, et al. Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study. Lancet Glob Health. 2018.

  4. Tack DM, Ray L, Griffin PM, Cieslak PR, Dunn J, Rissman T, et al. Preliminary incidence and trends of infections with pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2016–2019. MMWR Morb Mortal Wkly Rep. 2020;69(17):509–14.

    PubMed  PubMed Central  Google Scholar 

  5. Thepault A, Meric G, Rivoal K, Pascoe B, Mageiros L, Touzain F, et al. Genome-wide identification of host-segregating epidemiological markers for source attribution in Campylobacter jejuni. Appl Environ Microbiol. 2017:83(7).

  6. Young KT, Davis LM, Dirita VJ. Campylobacter jejuni: molecular biology and pathogenesis. Nat Rev. Microbiol. 2007;5(9):665–79.

    CAS  PubMed  Google Scholar 

  7. Zilbauer M, Dorrell N, Wren BW, Bajaj-Elliott M. Campylobacter jejuni-mediated disease pathogenesis: an update. Trans R Soc Trop Med Hyg. 2008;102(2):123–9.

    CAS  PubMed  Google Scholar 

  8. Taylor DN, Hamer DH, Shlim DR. Medications for the prevention and treatment of travellers’ diarrhea. J Travel Med. 2017;24(suppl_1):S17–22.

    PubMed  Google Scholar 

  9. Riddle MS, Tribble D. Preface: Guidelines for the treatment of travelers’ diarrhea in deployed military personnel. Mil Med. 2017;182(S2):1–3.

    PubMed  PubMed Central  Google Scholar 

  10. Antibiotic resistance threats in the United States, 2019. 2019.

  11. CDC. National Antimicrobial Resistance Monitoring System (NARMS) Now: Human Data. In. Atlanta, Georgia: U.S. Department of Health and Human Services, CDC; 2020.

  12. Ricotta EE, Palmer A, Wymore K, Clogher P, Oosmanally N, Robinson T, et al. Epidemiology and antimicrobial resistance of international travel-associated Campylobacter infections in the United States, 2005–2011. Am J Public Health. 2014;104(7):e108–14.

    PubMed  PubMed Central  Google Scholar 

  13. Riddle MS, DuPont HL, Connor BA. ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults. Am J Gastroenterol. 2016;111(5):602–22.

    CAS  PubMed  Google Scholar 

  14. Buss JE, Cresse M, Doyle S, Buchan BW, Craft DW, Young S. Campylobacter culture fails to correctly detect Campylobacter in 30% of positive patient stool specimens compared to non-cultural methods. Eur J Clin Microbiol Infect Dis. 2019;38(6):1087–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Liu F, Ma R, Wang Y, Zhang L. The clinical importance of Campylobacter concisus and other human hosted campylobacter species. Front Cell Infect Microbiol. 2018;8:243.

    PubMed  PubMed Central  Google Scholar 

  16. Campagnolo ER, Philipp LM, Long JM, Hanshaw NL. Pet-associated Campylobacteriosis: a persisting public health concern. Zoonoses Public Health. 2017.

  17. Amour C, Gratz J, Mduma E, Svensen E, Rogawski ET, McGrath M, et al. Epidemiology and impact of Campylobacter infection in children in 8 low-resource settings: Results From the MAL-ED Study. Clin Infect Dis. 2016;63(9):1171–9.

    PubMed  PubMed Central  Google Scholar 

  18. Buss SN, Leber A, Chapin K, Fey PD, Bankowski MJ, Jones MK, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015;53(3):915–25.

    PubMed  PubMed Central  Google Scholar 

  19. Halpin AL, Gu W, Wise ME, Sejvar JJ, Hoekstra RM, Mahon BE. Post-Campylobacter Guillain Barre Syndrome in the USA: secondary analysis of surveillance data collected during the 2009–2010 novel Influenza A (H1N1) vaccination campaign. Epidemiol Infect. 2018;146(13):1740–5.

    PubMed  PubMed Central  Google Scholar 

  20. Barrett E, Carr D, Bell ML, Pogreba-Brown K. Post-infectious sequelae after Campylobacter enteric infection: a pilot study in Maricopa County, Arizona. USA. Pilot Feasibility Stud. 2018;4:142.

    PubMed  Google Scholar 

  21. Centers for Disease C, Prevention. Multistate outbreak of Campylobacter jejuni infections associated with undercooked chicken livers--northeastern United States, 2012. MMWR Morb Mortal Wkly Rep. 2013;62(44):874–6.

    Google Scholar 

  22. Montgomery MP, Robertson S, Koski L, Salehi E, Stevenson LM, Silver R, et al. Multidrug-resistant Campylobacter jejuni Outbreak linked to puppy exposure - United States, 2016–2018. MMWR Morb Mortal Wkly Rep. 2018;67(37):1032–5.

    PubMed  PubMed Central  Google Scholar 

  23. Davis KR, Dunn AC, Burnett C, McCullough L, Dimond M, Wagner J, et al. Campylobacter jejuni infections associated with raw milk consumption--Utah, 2014. MMWR Morb Mortal Wkly Rep. 2016;65(12):301–5.

    PubMed  Google Scholar 

  24. Burakoff A, Brown K, Knutsen J, Hopewell C, Rowe S, Bennett C, et al. Outbreak of fluoroquinolone-resistant Campylobacter jejuni infections associated with raw milk consumption from a herdshare dairy - Colorado, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(5):146–8.

    PubMed  PubMed Central  Google Scholar 

  25. Cody AJ, Maiden MC, Strachan NJ, ND MC. A systematic review of source attribution of human campylobacteriosis using multilocus sequence typing. Euro Surveill. 2019:24(43).

  26. Tee W, Mijch A. Campylobacter jejuni bacteremia in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients: comparison of clinical features and review. Clin Infect Dis. 1998;26(1):91–6.

    CAS  PubMed  Google Scholar 

  27. Gaudreau C, Pilon PA, Sylvestre JL, Boucher F, Bekal S. Multidrug-resistant Campylobacter coli in men who have sex with men, Quebec, Canada, 2015. Emerg Infect Dis. 2016;22(9):1661–3.

    PubMed  PubMed Central  Google Scholar 

  28. Gaudreau C, Rodrigues-Coutlee S, Pilon PA, Coutlee F, Bekal S. Long-lasting outbreak of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni Subspecies jejuni from 2003 to 2013 in men who have sex with men, Quebec, Canada. Clin Infect Dis. 2015;61(10):1549–52.

    CAS  PubMed  Google Scholar 

  29. Marchand-Senecal X, Bekal S, Pilon PA, Sylvestre JL, Gaudreau C. Campylobacter fetus cluster among men who have sex with men, Montreal, Quebec, Canada, 2014–2016. Clin Infect Dis. 2017;65(10):1751–3.

    PubMed  Google Scholar 

  30. Snijders F, Kuijper EJ, de Wever B, van der Hoek L, Danner SA, Dankert J. Prevalence of Campylobacter-associated diarrhea among patients infected with human immunodeficiency virus. Clin Infect Dis. 1997;24(6):1107–13.

    CAS  PubMed  Google Scholar 

  31. Jenkin GA, Tee W. Campylobacter upsaliensis-associated diarrhea in human immunodeficiency virus-infected patients. Clin Infect Dis. 1998;27(4):816–21.

    CAS  PubMed  Google Scholar 

  32. Gaudreau C, Helferty M, Sylvestre JL, Allard R, Pilon PA, Poisson M, et al. Campylobacter coli outbreak in men who have sex with men, Quebec, Canada, 2010–2011. Emerg Infect Dis. 2013;19(5):764–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Greninger AL, Addetia A, Starr K, Cybulski RJ, Stewart MK, Salipante SJ, et al. International spread of multidrug-resistant campylobacter coli in men who have sex with men in Washington State and Quebec, 2015–2018. Clin Infect Dis. 2019.

  34. Gaudreau C, Michaud S. Cluster of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni subsp. jejuni from 1999 to 2001 in men who have sex with men, Quebec, Canada. Clin Infect Dis. 2003;37(1):131–6.

    PubMed  Google Scholar 

  35. Black RE, Levine MM, Clements ML, Hughes TP, Blaser MJ. Experimental Campylobacter jejuni infection in humans. J Infect Dis. 1988;157(3):472–9.

    CAS  PubMed  Google Scholar 

  36. Mook P, Gardiner D, Kanagarajah S, Kerac M, Hughes G, Field N, et al. Use of gender distribution in routine surveillance data to detect potential transmission of gastrointestinal infections among men who have sex with men in England. Epidemiol Infect. 2018;146(11):1468–77.

    CAS  PubMed  Google Scholar 

  37. Najjar I, Paluca F, Loukidis K, Tarr PE. Recurrent Campylobacter enteritis in patients with hypogammaglobulinemia: review of the literature. J Clin Med. 2020:9(2).

  38. Dan M, Parizade M. Chronic high-level multidrug-resistant Campylobacter coli enterocolitis in an agammaglobulinemia patient: Oral gentamicin efficacy. Med Mal Infect. 2020.

  39. Arslan H, Inci EK, Azap OK, Karakayali H, Torgay A, Haberal M. Etiologic agents of diarrhea in solid organ recipients. Transpl Infect Dis. 2007;9(4):270–5.

    CAS  PubMed  Google Scholar 

  40. Coste JF, Vuiblet V, Moustapha B, Bouin A, Lavaud S, Toupance O, et al. Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. J Clin Microbiol. 2013;51(6):1841–9.

    PubMed  PubMed Central  Google Scholar 

  41. Otto CC, Chen LH, He T, Tang YW, Babady NE. Detection of gastrointestinal pathogens in oncology patients by highly multiplexed molecular panels. Eur J Clin Microbiol Infect Dis. 2017;36(9):1665–72.

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Schvartz B, Garcia M, Wolak-Thierry A, De Champs C, Leveque N. Risk factors of asymptomatic shedding of enteric pathogens in renal transplant recipients. Transpl Infect Dis. 2016;18(3):480–2.

    CAS  PubMed  Google Scholar 

  43. Imai N, Uchida D, Hanada M, Sasaki S, Shibagaki Y, Chikaraishi T, et al. A case of Campylobacter enteritis in a renal transplant recipient. Transplantation. 2013;95(12):e78–9.

    PubMed  Google Scholar 

  44. Ban H, Miura K, Ishizuka K, Kaneko N, Taniguchi Y, Nagasawa T, et al. Clinical characteristics of Campylobacter enteritis after pediatric renal transplantation: A retrospective analysis from single center. Transpl Infect Dis. 2019;21(2):e13040.

    PubMed  Google Scholar 

  45. Toussaint N, Goodman D, Langham R, Gock H, Hill P. Haemorrhagic Campylobacter jejuni and CMV colitis in a renal transplant recipient. Nephrol Dial Transplant. 2005;20(4):823–6.

    PubMed  Google Scholar 

  46. Ostman C, Chacko B. Guillain-Barre syndrome post renal transplant: a systematic review. Transpl Infect Dis. 2019;21(1):e13021.

    PubMed  Google Scholar 

  47. Yuki N. Guillain-Barre syndrome and anti-ganglioside antibodies: a clinician-scientist’s journey. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(7):299–326.

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Feodoroff B, Ellstrom P, Hyytiainen H, Sarna S, Hanninen ML, Rautelin H. Campylobacter jejuni isolates in Finnish patients differ according to the origin of infection. Gut Pathog. 2010;2(1):22.

    PubMed  PubMed Central  Google Scholar 

  49. Samuel MC, Vugia DJ, Shallow S, Marcus R, Segler S, McGivern T, et al. Epidemiology of sporadic Campylobacter infection in the United States and declining trend in incidence, FoodNet 1996–1999. Clin Infect Dis. 2004;38(Suppl 3):S165–74.

    PubMed  Google Scholar 

  50. Nielsen H, Hansen KK, Gradel KO, Kristensen B, Ejlertsen T, Ostergaard C, et al. Bacteraemia as a result of Campylobacter species: a population-based study of epidemiology and clinical risk factors. Clin Microbiol Infect. 2010;16(1):57–61.

    CAS  PubMed  Google Scholar 

  51. Skirrow MB, Jones DM, Sutcliffe E, Benjamin J. Campylobacter bacteraemia in England and Wales, 1981–91. Epidemiol Infect. 1993;110(3):567–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Louwen R, van Baarlen P, van Vliet AH, van Belkum A, Hays JP, Endtz HP. Campylobacter bacteremia: a rare and under-reported event? Eur J Microbiol Immunol (Bp). 2012;2(1):76–87.

    CAS  Google Scholar 

  53. Shandera WX, Tormey MP, Blaser MJ. An outbreak of bacteremic Campylobacter jejuni infection. Mt Sinai J Med. 1992;59(1):53–6.

    CAS  PubMed  Google Scholar 

  54. Pacanowski J, Lalande V, Lacombe K, Boudraa C, Lesprit P, Legrand P, et al. Campylobacter bacteremia: clinical features and factors associated with fatal outcome. Clin Infect Dis. 2008;47(6):790–6.

    PubMed  Google Scholar 

  55. van den Bruele T, Mourad-Baars PE, Claas EC, van der Plas RN, Kuijper EJ, Bredius RG. Campylobacter jejuni bacteremia and Helicobacter pylori in a patient with X-linked agammaglobulinemia. Eur J Clin Microbiol Infect Dis. 2010;29(11):1315–9.

    PubMed  PubMed Central  Google Scholar 

  56. Wyatt RA, Younoszai K, Anuras S, Myers MG. Campylobacter fetus septicemia and hepatitis in a child with agammaglobulinemia. J Pediatr. 1977;91(3):441–2.

    CAS  PubMed  Google Scholar 

  57. Hagiya H, Kimura K, Nishi I, Yoshida H, Yamamoto N, Akeda Y, et al. Emergence of Carbapenem non-susceptible Campylobacter coli after long-term treatment against recurrent bacteremia in a patient with X-linked Agammaglobulinemia. Intern Med. 2018;57(14):2077–80.

    PubMed  PubMed Central  Google Scholar 

  58. Ariganello P, Angelino G, Scarselli A, Salfa I, Della Corte M, De Matteis A, et al. Relapsing Campylobacter jejuni systemic infections in a child with X-linked agammaglobulinemia. Case Rep Pediatr. 2013;2013:735108.

    PubMed  PubMed Central  Google Scholar 

  59. Okada H, Kitazawa T, Harada S, Itoyama S, Hatakeyama S, Ota Y, et al. Combined treatment with oral kanamycin and parenteral antibiotics for a case of persistent bacteremia and intestinal carriage with Campylobacter coli. Intern Med. 2008;47(14):1363–6.

    PubMed  Google Scholar 

  60. Tokuda K, Nishi J, Miyanohara H, Sarantuya J, Iwashita M, Kamenosono A, et al. Relapsing cellulitis associated with Campylobacter coli bacteremia in an agammaglobulinemic patient. Pediatr Infect Dis J. 2004;23(6):577–9.

    PubMed  Google Scholar 

  61. Arai A, Kitano A, Sawabe E, Kanegane H, Miyawaki T, Miura O. Relapsing Campylobacter coli bacteremia with reactive arthritis in a patient with X-linked agammaglobulinemia. Intern Med. 2007;46(9):605–9.

    PubMed  Google Scholar 

  62. Gharamti AA, Moukalled N, Taher A, Kanafani ZA. Recurrent Campylobacter bacteremia as the first manifestation of hypogammaglobulinemia: a case report and literature review. Infect Chemother. 2019.

  63. Janssen R, Krogfelt KA, Cawthraw SA, van Pelt W, Wagenaar JA, Owen RJ. Host-pathogen interactions in Campylobacter infections: the host perspective. Clin Microbiol Rev. 2008;21(3):505–18.

    PubMed  PubMed Central  Google Scholar 

  64. Kim Y, Shin JA, Han SB, Cho B, Jeong DC, Kang JH. Recurrent Campylobacter jejuni bacteremia in a patient with hypogammaglobulinemia: A case report. Medicine (Baltimore). 2017;96(25):e7238.

    Google Scholar 

  65. Liu YH, Yamazaki W, Huang YT, Liao CH, Sheng WH, Hsueh PR. Clinical and microbiological characteristics of patients with bacteremia caused by Campylobacter species with an emphasis on the subspecies of C. fetus. J Microbiol Immunol Infect. 2019;52(1):122–31.

    PubMed  Google Scholar 

  66. Anvarinejad M, Amin Shahidi M, Pouladfar GR, Dehyadegari MA, Mardaneh J. Campylobacter jejuni bacteremia in a patient with acute lymphocytic leukemia. Iran Red Crescent Med J. 2016;18(6):e23992.

    PubMed  PubMed Central  Google Scholar 

  67. Martora F, Pagliuca C, Della Pepa ME, Della Rocca MT, Curto S, Iovene MR, et al. Campylobacter jejuni bacteremia in Italian pediatric patients with acute lymphoblastic leukemia: report of two cases. New Microbiol. 2020;43(2).

  68. Tu ZC, Zeitlin G, Gagner JP, Keo T, Hanna BA, Blaser MJ. Campylobacter fetus of reptile origin as a human pathogen. J Clin Microbiol. 2004;42(9):4405–7.

    PubMed  PubMed Central  Google Scholar 

  69. Gallo MT, Di Domenico EG, Toma L, Marchesi F, Pelagalli L, Manghisi N, et al. Campylobacter jejuni fatal sepsis in a patient with non-hodgkin’s lymphoma: case report and literature review of a difficult diagnosis. Int J Mol Sci. 2016;17(4):544.

    PubMed  PubMed Central  Google Scholar 

  70. Monselise A, Blickstein D, Ostfeld I, Segal R, Weinberger M. A case of cellulitis complicating Campylobacter jejuni subspecies jejuni bacteremia and review of the literature. Eur J Clin Microbiol Infect Dis. 2004;23(9):718–21.

    CAS  PubMed  Google Scholar 

  71. Reinwald M, Boch T, Hofmann WK, Buchheidt D. Risk of infectious complications in hemato-oncological patients treated with kinase inhibitors. Biomark Insights. 2015;10(Suppl 3):55–68.

    CAS  PubMed  Google Scholar 

  72. van Samkar A, Brouwer MC, van der Ende A, van de Beek D. Zoonotic bacterial meningitis in human adults. Neurology. 2016;87(11):1171–9.

    PubMed  Google Scholar 

  73. Kusulja M, Santini M, Margetic K, Guzvinec M, Soprek S, Butic I, et al. Meningitis caused by Campylobacter jejuni: a case presentation and literature review. Acta Clin Belg. 2020:1–6.

  74. van Samkar A, Brouwer MC, van der Ende A, van de Beek D. Campylobacter fetus meningitis in adults: report of 2 cases and review of the literature. Medicine (Baltimore). 2016;95(8):e2858.

    Google Scholar 

  75. Tanabe S, Kutsuna S, Tsuboi M, Takeshita N, Hayakawa K, Ohmagari N. Meningoencephalitis caused by a Campylobacter fetus in a patient with chronic alcoholism. Intern Med. 2019;58(15):2247–50.

    PubMed  PubMed Central  Google Scholar 

  76. Suy F, Le Du D, Roux AL, Hanachi M, Dinh A, Cremieux AC. Meningitis and endocarditis caused by Campylobacter fetus after raw-liver ingestion. J Clin Microbiol. 2013;51(9):3147–50.

    PubMed  PubMed Central  Google Scholar 

  77. Herve J, Aissa N, Legrand P, Sorkine M, Calmette MJ, Santin A, et al. Campylobacter fetus meningitis in a diabetic adult cured by imipenem. Eur J Clin Microbiol Infect Dis. 2004;23(9):722–4.

    CAS  PubMed  Google Scholar 

  78. Moon J, Kim N, Lee HS, Shin HR, Lee ST, Jung KH, et al. Campylobacter fetus meningitis confirmed by a 16S rRNA gene analysis using the MinION nanopore sequencer, South Korea, 2016. Emerg Microbes Infect. 2017;6(11):e94.

    CAS  PubMed  PubMed Central  Google Scholar 

  79. Ikeda K, Manabe Y, Fujiwara S, Omote Y, Narai H, Abe K. Campylobacter fetus meningitis and pyogenic spondylodiscitis in a healthy young woman. Case Rep Neurol. 2019;11(3):299–303.

    PubMed  PubMed Central  Google Scholar 

  80. Ishihara A, Hashimoto E, Ishioka H, Kobayashi H, Gomi H. Campylobacter fetus meningitis associated with eating habits of raw meat and raw liver in a healthy patient: a case report and literature review. IDCases. 2018;11:97–100.

    PubMed  PubMed Central  Google Scholar 

  81. Cambier A, Martiny D, Hallin M, Wautier M, Giot JB, Khaldi MZ, et al. Campylobacter coli meningitis in a 57-year-old patient. Acta Clin Belg. 2018;73(6):427–30.

    PubMed  Google Scholar 

  82. Martinez-Balzano C, Kohlitz PJ, Chaudhary P, Hegazy H. Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. J Infect. 2013;66(2):184–6.

    PubMed  Google Scholar 

  83. Morooka T, Takeo H, Yasumoto S, Mimatsu T, Yukitake K, Oda T. Nosocomial meningitis due to Campylobacter fetus subspecies fetus in a neonatal intensive care unit. Acta Paediatr Jpn. 1992;34(5):530–3.

    CAS  PubMed  Google Scholar 

  84. Goossens H, Henocque G, Kremp L, Rocque J, Boury R, Alanio G, et al. Nosocomial outbreak of Campylobacter jejuni meningitis in newborn infants. Lancet. 1986;2(8499):146–9.

    CAS  PubMed  Google Scholar 

  85. Petridou C, Strakova L, Simpson R. Campylobacter fetus prosthetic valve endocarditis presenting as a stroke. JMM Case Rep. 2018;5(5):e005147.

    PubMed  PubMed Central  Google Scholar 

  86. Lynch C, O’Connor JA, O’Brien D, Vaughan C, Bolton D, Coffey A, et al. First reported detection of biofilm formation by Campylobacter fetus during investigation of a case of prosthetic valve endocarditis. J Clin Pathol. 2019;72(8):554–7.

    CAS  PubMed  Google Scholar 

  87. Haruyama A, Toyoda S, Kikuchi M, Arikawa T, Inami S, Otani N, et al. Campylobacter fetus as cause of prosthetic valve endocarditis. Tex Heart Inst J. 2011;38(5):584–7.

    PubMed  PubMed Central  Google Scholar 

  88. Reid MJ, Shannon EM, Baxi SM, Chin-Hong P. Steak tartare endocarditis. BMJ Case Rep. 2016;2016.

  89. Sekowska A, Fabiszak T, Mikucka A, Andrzejewska M, Kruszynska E, Gospodarek E, et al. A case of defibrillator-associated infective endocarditis due to Campylobacter fetus. Folia Microbiol (Praha). 2016;61(6):529–32.

    CAS  Google Scholar 

  90. Puljiz I, Topic A. Campylobacter jejuni vertebral osteomyelitis. Lancet Infect Dis. 2017;17(9):1002.

    PubMed  Google Scholar 

  91. Hartman J, Westerman M, Wagenaar JFP. Two-sided femoral Campylobacter jejuni osteomyelitis in a patient with acquired hypogammaglobulinemia: a case report. BMC Infect Dis. 2020;20(1):199.

    CAS  PubMed  PubMed Central  Google Scholar 

  92. Chaillon A, Baty G, Lauvin MA, Besnier JM, Goudeau A, Lanotte P. Campylobacter fetus subspecies fetus spondylodiscitis. J Med Microbiol. 2010;59(Pt 12):1505–8.

    PubMed  Google Scholar 

  93. Laenens D, Plazier M, van der Hilst JCH, Messiaen P. Campylobacter fetus spondylodiscitis in a patient with HIV infection and restored CD4 count. BMJ Case Rep. 2018;2018.

  94. Olaiya D, Fok R, Chakrabarti P, Sharma H, Greig J. Campylobacter fetus spondylodiscitis: a case report and review of the literature. IDCases. 2018;14:e00468.

    PubMed  PubMed Central  Google Scholar 

  95. Tanaka A, Takahashi J, Hirabayashi H, Ogihara N, Mukaiyama K, Shimizu M, et al. A case of pyogenic spondylodiscitis caused by Campylobacter fetus for which early diagnosis by magnetic resonance imaging was difficult. Asian Spine J. 2012;6(4):274–8.

    PubMed  PubMed Central  Google Scholar 

  96. Lemaire X, Dehecq C, Cattoen C, Garnier LD, Bournet BS, Yazdanpanah Y, et al. Spondylodiscitis and an aortic aneurysm due to Campylobacter coli. Ann Clin Microbiol Antimicrob. 2010;9:8.

    PubMed  PubMed Central  Google Scholar 

  97. Tappe D, Schulze MH, Oesterlein A, Abele-Horn M, Baron S, Durchholz D, et al. Molecular detection of Campylobacter jejuni as a cause of culture-negative spondylodiscitis. J Clin Microbiol. 2012;50(4):1499–500.

    PubMed  PubMed Central  Google Scholar 

  98. Oka K, Nakano Y, Sazumi Y, Michitani T, Horiguchi S, Ocho K, et al. Clival osteomyelitis with cavernous sinus thrombosis due to Fusobacterium nucleatum and Campylobacter rectus induced by tooth extraction. Intern Med. 2018;57(22):3325–8.

    PubMed  PubMed Central  Google Scholar 

  99. Martiny D, Dauby N, Konopnicki D, Kampouridis S, Jissendi Tchofo P, Horoi M, et al. MALDI-TOF MS contribution to the diagnosis of Campylobacter rectus multiple skull base and brain abscesses. New Microbes New Infect. 2017;19:83–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  100. Leo QJ, Bolger DT Jr. Septic cavernous sinus thrombosis due to Campylobacter rectus infection. BMJ Case Rep 2014. 2014.

  101. Lam JY, Wu AK, Ngai DC, Teng JL, Wong ES, Lau SK, et al. Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C. rectus infection. J Clin Microbiol. 2011;49(4):1687–91.

    PubMed  PubMed Central  Google Scholar 

  102. Chen NY, Bender JM, Bard JD, Trost MJ, Corden MH. Something does not smell right: when a patient with empyema isn’t responding to guideline-based management. Hosp Pediatr. 2016;6(11):702–6.

    PubMed  Google Scholar 

  103. Noel A, Verroken A, Belkhir L, Rodriguez-Villalobos H. Fatal thoracic empyema involving Campylobacter rectus: A case report. Anaerobe. 2018;49:95–8.

    CAS  PubMed  Google Scholar 

  104. Ogata T, Urata T, Nemoto D, Hitomi S. Thoracic empyema caused by Campylobacter rectus. J Infect Chemother. 2017;23(3):185–8.

    PubMed  Google Scholar 

  105. Horio Y, Shiraishi Y, Watanabe N, Inoue S, Imanishi T, Asano K. Empyema associated with Campylobacter curvus infection. Respirol Case Rep. 2017;5(4):e00234.

    PubMed  PubMed Central  Google Scholar 

  106. Hagemann JB, Haverkamp S, Gruner B, Kuchenbauer F, Essig A. Pulmonary Campylobacter concisus infection in an immunocompromised patient with underlying mucormycosis. Int J Infect Dis. 2018;76:45–7.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Veterinary Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru

    Francesca Schiaffino DVM, PhD

  2. Division of Infectious Diseases, University of Virginia, 345 Crispell Dr, Rm, Charlottesville, VA, 2525, USA

    Francesca Schiaffino DVM, PhD & Margaret N. Kosek MD

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  1. Francesca Schiaffino DVM, PhD
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  2. Margaret N. Kosek MD
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Correspondence to Margaret N. Kosek MD.

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Dr. Schiaffino has nothing to disclose. Dr. Kosek has nothing to disclose.

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Schiaffino, F., Kosek, M.N. Intestinal and Extra-Intestinal Manifestations of Campylobacter in the Immunocompromised Host. Curr Treat Options Infect Dis 12, 361–374 (2020). https://doi.org/10.1007/s40506-020-00243-4

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