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The ABCD Study of Neurodevelopment: Identifying Neurocircuit Targets for Prevention and Treatment of Adolescent Substance Abuse

  • Substance Use Disorders (FG Moeller, Section Editor)
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Opinion statement

Substance use disorders (SUD) can be considered developmental disorders in light of their frequent origins in substance initiation during adolescence. Cross-sectional functional magnetic resonance imaging (fMRI) studies of adolescent substance users or adolescents with SUD have indicated aberrations in brain structures or circuits implicated in motivation, self-control, and mood-regulation. However, attributing these differences to the neurotoxicological effects of chronic substance use has been problematic in that these circuits are also aberrant in at-risk children, such as those with prenatal substance exposure, externalizing disorders (such as conduct disorder), or prodromal internalizing disorders such as depression. To better isolate the effects of substance exposure on the adolescent brain, the newly launched Adolescent Brain Cognitive Development (ABCD) study, funded by the National Institutes of Health, will follow the neurodevelopmental trajectories of over 11,000 American 9- to 10-year-olds for 10 years, into emerging adulthood. This study will provide a rich open-access dataset on longitudinal interactions of neurodevelopment, environmental exposures, and childhood psychopathology that confer addiction risk. The ABCD twin study will further clarify genetic versus experiential influences (e.g., substance use) on neurodevelopmental and psychosocial outcomes. Neurocircuitry thought to regulate mood and behavior has been directly normalized by administration of psychoactive medications and by cognitive therapies in adults. Because of this, we contend that ABCD project data will be a crucial resource for prevention and treatment of SUD in adolescence because its cutting-edge neuroimaging and childhood assessments hold potential for discovery of additional targetable brain differences earlier in development that are prognostic of (or aberrant in) SUD. The ABCD sample size will also have the power to illuminate how sex differences, environmental interactions, and other individual differences interact with neurodevelopment to inform treatment in different groups of adolescents.

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Acknowledgements

This manuscript was prepared under the salary support to JMB and MCN afforded by cooperative agreement 1U01DA041120.

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Authors and Affiliations

  1. Department of Psychiatry, Virginia Commonwealth University, 203 E. Cary Street, Room 202, Richmond, VA, 23219, USA

    James M. Bjork PhD, Lisa K. Straub MS, Rosellen G. Provost BS & Michael C. Neale PhD

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Correspondence to James M. Bjork PhD.

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James M. Bjork declares that he has no conflict of interest.

Lisa K. Straub declares that she has no conflict of interest.

Rosellen G. Provost declares that she has no conflict of interest.

Michael C. Neale declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

Recruitment and procedures of each site and the coordinating center of the ABCD study are continually monitored by the ABCD External Advisory Board and the Bioethics and Medical Oversight advisory panel, and have been approved by either the local site Institutional Review Board (IRB) or by local IRB reliance agreements with the central IRB of the University of California-San Diego (site of the ABCD Coordinating Center).

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Bjork, J.M., Straub, L.K., Provost, R.G. et al. The ABCD Study of Neurodevelopment: Identifying Neurocircuit Targets for Prevention and Treatment of Adolescent Substance Abuse. Curr Treat Options Psych 4, 196–209 (2017). https://doi.org/10.1007/s40501-017-0108-y

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