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Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review

  • Systemic Diseases (N Buduneli, Section Editor)
  • Published:
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Abstract

Purpose of Review

Research suggests that periodontal tissue might serve as a reservoir for oral human papillomavirus (HPV) infection, while another hypothesis is that chronic inflammation of the tissue might perpetuate an infection with oral HPV infection. In this narrative review, we summarize the evidence related to a potential association between oral HPV infection and periodontitis.

Recent Findings

Twelve articles were identified, and their key findings summarized. Studies vary in sample size, study population, study design, and methods for assessment of oral HPV and periodontitis. Although results are conflicting and still inconclusive, various studies have found an association between oral HPV infection and periodontitis, which is supported by biological plausibility.

Summary

Future longitudinal studies should further evaluate this association, using clinical definitions of oral HPV infection and periodontitis, and focusing on high-risk populations for oral HPV infection. Studying this association is important since periodontitis might help identify at-risk individuals for oral HPV infection and potentially HPV-related oropharyngeal cancers.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgements

This work was supported by the National Institutes of Health [1R21DE024850-01A1, NIDCR] and [1R21DE027226-01A1, NIDCR].

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Authors and Affiliations

  1. Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico Medical Sciences Campus, P.O. Box 365067, San Juan, 00936-5067, Puerto Rico

    Ana P. Ortiz & Cynthia M. Pérez

  2. Cancer Control and Population Sciences Division, University of Puerto Rico Comprehensive Cancer Center, P.O. Box 363027, San Juan, 00936-3027, Puerto Rico

    Ana P. Ortiz, Jeslie M. Ramos-Cartagena & Sandra I. García-Camacho

  3. Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, Medical Sciences Campus, P.O. Box 365067, San Juan, 00936-5067, Puerto Rico

    Oelisoa M. Andriankaja

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  1. Ana P. Ortiz
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Correspondence to Ana P. Ortiz.

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Ortiz, A.P., Ramos-Cartagena, J.M., García-Camacho, S.I. et al. Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review. Curr Oral Health Rep 6, 22–30 (2019). https://doi.org/10.1007/s40496-019-0206-6

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