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What Are We Learning and What Can We Learn from the Human Oral Microbiome Project?

  • Microbiology (M Klein, Section Editor)
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Abstract

Extraordinary technological advances in DNA sequencing have greatly accelerated our ability to identify bacteria, at the species level, present in clinical samples taken from the human mouth. In addition, mass spectrometry has evolved such that oral samples can be analyzed for protein and metabolic products, providing insight into bacterial interaction with their human hosts in the maintenance of oral health or the onset of disease. The ability to cost-effectively determine the DNA sequence of individuals, accompanied by their unique microbiome, heralds the advent of personalized dental medicine.

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Acknowledgments

This work was supported by the Training Program in Oral Sciences, NIH/NIDCR T90 DE021985 (B. C.), NIH/NIDCR DE013683, and DE017157 (R.G.Q.).

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  1. Eastman Institute for Oral Health, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Box 611, 601 Elmwood Ave., Rochester, NY, 14642, USA

    Benjamin Cross, Roberta C. Faustoferri & Robert G. Quivey Jr.

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Cross, B., Faustoferri, R.C. & Quivey, R.G. What Are We Learning and What Can We Learn from the Human Oral Microbiome Project?. Curr Oral Health Rep 3, 56–63 (2016). https://doi.org/10.1007/s40496-016-0080-4

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