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Diet, Obesity, Diabetes, and Periodontitis: a Syndemic Approach to Management

  • Systemic Diseases (M Bartold, Section Editor)
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Abstract

A healthy diet is important to the maintenance of good general health. An imbalanced diet can increase risk for the development of obesity and insulin resistance which can eventually lead to the onset of diabetes. Nutrition, obesity, and diabetes are all known risk factors for periodontal diseases. Periodontitis in turn is a risk factor for the development of diabetes and can complicate the management of those who suffer from obesity and/or diabetes. The interplay of these three common chronic inflammatory diseases suggests that a syndemic approach to prevention and management would best address the shared risk for all of these diseases and help to break the cycle of pro-inflammatory events leading to chronic inflammation as assessed by elevations in C-reactive protein, driven by elevations in cytokines such as IL-6 and TNF-α as well as oxidative stress. These interactions may synergistically increase risk for cardiovascular disease, the number one cause of death worldwide. Oral health care providers can play a major role, as members of an interdisciplinary team of healthcare providers, in addressing this syndemic.

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Authors and Affiliations

  1. Department of Oral Biology and Pathology, Stony Brook University, 185 Westchester Hall, Stony Brook, NY, 11794-8702, USA

    Maria Emanuel Ryan & Veena Raja

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  1. Maria Emanuel Ryan
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  2. Veena Raja
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Correspondence to Maria Emanuel Ryan.

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Veena Raja declares that she has no conflict of interest.

Maria Emanuel Ryan is a co-inventor on issued patents to prevent long-term complications of diabetes and to inhibit glycation proteins with tetracycline compounds. In addition, the host modulatory therapy Periostat (subantimicrobial dose doxycycline) was developed at Stony Brook University in the Department of Oral Biology and Pathology.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Ryan, M.E., Raja, V. Diet, Obesity, Diabetes, and Periodontitis: a Syndemic Approach to Management. Curr Oral Health Rep 3, 14–27 (2016). https://doi.org/10.1007/s40496-016-0075-1

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