Current Tropical Medicine Reports

, Volume 5, Issue 1, pp 5–15 | Cite as

Prevention Strategies to Combat Antimicrobial Resistance in Children in Resource-Limited Settings

  • Alejandro Diaz
  • Stella Antonara
  • Theresa Barton
Pediatric Global Health (D Nguyen and A Mandalakas, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Pediatric Global Health

Abstract

Purpose of Review

This review summarizes major antimicrobial-resistant pathogens emerging globally, including mechanisms of resistance and factors leading to acquisition of drug resistance in children. It further seeks to answer what steps should be taken in resource-limited settings to curb spread of these resistant pathogens.

Recent Findings

Prevalence of drug resistance bacteria is increasing in children. Resistance is primarily driven by antibiotic overuse and misuse, amplified in developing countries by poor regulation and limited treatment options. The World Health Organization has outlined a comprehensive approach to reduce antimicrobial resistance. Data among children in the developing world are incomplete, but suggest this is a problem with huge healthcare costs.

Summary

Prevention methods include classic sanitation, infection control, antimicrobial stewardship, as well as development of new technologies and improved surveillance. Future research should focus on population benefits, cost effectiveness of different approaches, and applying new technologies in a regulated way to the developing world.

Keywords

Antimicrobial resistance Infection control Antimicrobial stewardship Carbapenemase ESBL 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018
corrected publication March/2018

Authors and Affiliations

  • Alejandro Diaz
    • 1
  • Stella Antonara
    • 1
  • Theresa Barton
    • 2
  1. 1.Nationwide Children’s HospitalColumbusUSA
  2. 2.Baylor College of Medicine and Texas Children’s HospitalHoustonUSA

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