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Pharmaceutical Interventions for Tourette’s Syndrome

  • Tourette's Syndrome (TS Zeiger, Section Editor)
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Abstract

Tourette’s syndrome is a childhood-onset neuropsychiatric disorder characterized by motor and vocal tics that are chronic (duration of >1 year) (Kurlan N Engl J Med. 363:2332; Jankovic and Kurlan Mov Disord. 26:1149; Diagnostic and statistical manual of psychiatry. 4th ed.). Tics are commonly associated with obsessive–compulsive symptoms and disturbances of attention. In many children with Tourette’s syndrome, tics are mild and not disabling, and education about the condition with supportive counseling is sufficient. However, tics can be disabling by causing social embarrassment, school bullying, isolation, and sometimes conflict. Some tics are painful, and some can be self-injurious. When tics are disabling, tic-suppressing therapy is indicated which can be behavioral therapy and/or pharmacotherapy. Treatment of associated ADHD and OCD symptoms is also warranted when they are disabling.

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References

  1. Kurlan R. Clinical practice: Tourette’s syndrome. N Engl J Med. 2010;363:2332.

    Article  CAS  PubMed  Google Scholar 

  2. Jankovic J, Kurlan R. Tourette syndrome: evolving concepts. Mov Disord. 2011;26:1149.

    Article  PubMed  Google Scholar 

  3. Diagnostic and statistical manual of psychiatry. 4th ed. rev. Washington, DC: American Psychiatric Association, 2000.

  4. Scharf JM, Miller LL, Gauvin CA, et al. Population prevalence of Tourette syndrome: a systematic review and meta-analysis. Mov Disord. 2015;30:221.

    Article  PubMed  Google Scholar 

  5. RD F, DK F, Burd L, et al. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol. 2000;42:436.

    Article  Google Scholar 

  6. Kwak C, Dat Vuong K, Jankovic J. Premonitory sensory phenomenon in Tourette’s syndrome. Mov Disord. 2003;18:1530.

    Article  PubMed  Google Scholar 

  7. Freeman RD, Zinner SH, Muller-Vahl KR, et al. Coprophenomena in Tourette syndrome. Dev Med Child Neurol. 2009;51:218–27.

    Article  PubMed  Google Scholar 

  8. Jankovic J. Tourette’s syndrome. N Engl J Med. 2001;345:1184–92.

    Article  CAS  PubMed  Google Scholar 

  9. Pauls DL, Leckman JF. The inheritance of Gilles de la Tourette’s syndrome and associated behaviors: evidence for autosomal dominant transmission. N Engl J Med. 1986;315:993–7.

    Article  CAS  PubMed  Google Scholar 

  10. Leckman JF, Zhang H, Vitale A, et al. Course of tic severity in Tourette syndrome:the first two decades. Pediatrics. 1998;102:14–9.

    Article  CAS  PubMed  Google Scholar 

  11. Piacentini J, Woods DW, Scahill L, et al. Behavior therapy for children with Tourette disorder :a randomized controlled trial. JAMA. 2010;303:1929–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Roessner V, Plessner K, Rothenberger A, Ludolph A, Rizzo R, Skov L, et al. European guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. Eur Child Adolesc Psychiat. 2011;20(4):173–96.

    Article  Google Scholar 

  13. Scahill L, Chappell PB, Kim YS, et al. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry. 2001;158:1067–74.

    Article  CAS  PubMed  Google Scholar 

  14. Leckman JF, Hardin MT, Riddle MA, Stevenson J, Orf SI, Cohen DJ. Clonidine treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry. 2001;158:1067–74.

    Article  PubMed  Google Scholar 

  15. Pringsheim T, Marras C. Pimozide for tics in Tourette’s syndrome. Cochrane Database Syst Rev 2009:CD006996.

  16. Ross MS, Moldofsky H. A comparison of pimozide and haloperidol in the treatment of Gilles de la Tourette’s syndrome. Am J Psychiatry. 1978;135:585–7.

    Article  CAS  PubMed  Google Scholar 

  17. Dion Y, Annable L, Sandor P, et al. Resperidone in the treatment of Tourette syndrome: a double blind, placebo-controlled trial. J Clin Psychopharmacol. 2002;22:31–9.

    Article  CAS  PubMed  Google Scholar 

  18. Muller-Vahl KR, Krueger D. Does Tourette syndrome prevent tardive dyskinesia? Movment Disord. 2011;26(13):2442–3.

    Article  Google Scholar 

  19. Porta M, Sassi M, Cavallazzi M, et al. Tourette’s syndrome and role of tetrabenazine: review and personal experience. Clin Drug Investig. 2008:443–59.

  20. Jimenez-Shahed JJ, LW B. A randomized, double-blind, placebo-controlled study of topiramate in the treatment of Tourette syndrome. J Neurol NeurosurgPsychiatry. 2010;81:70–3.

    Article  Google Scholar 

  21. Marras C, Andrews D, Sime E, Lang AE. Botulism toxin for simple motor tics: a randomized, double-blind, controlled clinical trial. Neurology. 2001;56:605.

    Article  CAS  PubMed  Google Scholar 

  22. Kwak CH, Hanna PA, Jankovic J. Botulinum toxin in the treatment of tics. Arch Neurol. 2000;57:1190.

    Article  CAS  PubMed  Google Scholar 

  23. Tourette’s Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002;58:527–36.

    Article  Google Scholar 

  24. Nass R, Bressman S. Attention deficit hyperactivity disorder and Tourette syndrome: what’s the best treatment? Neurology. 2002;58:513.

    Article  PubMed  Google Scholar 

  25. Allen AJ, Kurlan RM, Gilbert DL, et al. Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology. 2005;65:1941–9.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Gayatra Mainali.

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Laura Duda and Gayatra Mainali declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Tourette’s Syndrome

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Duda, L., Mainali, G. Pharmaceutical Interventions for Tourette’s Syndrome. Curr Dev Disord Rep 3, 213–216 (2016). https://doi.org/10.1007/s40474-016-0098-2

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  • DOI: https://doi.org/10.1007/s40474-016-0098-2

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