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Neurobiological Considerations for Tobacco Use Disorder

  • Addictions (M Potenza and M Brand, Section Editors)
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Abstract

Purpose of Review

Neurobiological studies of tobacco/nicotine use examining genetic, molecular, functional, and behavioral correlates have improved our understanding of tobacco/nicotine dependence and have informed treatment. Recent work extending previously established findings and reporting novel methodologies and discoveries in preclinical and human studies are reviewed.

Recent Findings

Recent work in preclinical models has focused on the differential roles of nicotinic receptor subtypes and nicotine’s effects on neural systems beyond cortico-striatal dopaminergic pathways, and utilizing advanced methodologies such as pharmacogenetics, optogenetics, and rodent fMRI to identify targets for treatment. Likewise, human neuroimaging studies have identified molecular and functional dynamic shifts associated with tobacco/nicotine use that further inform treatment.

Summary

Tobacco/nicotine use is associated with widespread neural adaptations that are persistent and function to maintain addiction. The continued identification of genetic, molecular, neural, and behavioral endophenotypes related to tobacco/nicotine use, dependence, and addiction will facilitate the development and delivery of personalized treatment.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Neuroscience, Yale School of Medicine, 310 Cedar Street, Brady Memorial Laboratory #407, New Haven, CT, 06510, USA

    Megha Chawla

  2. Department of Psychiatry, Yale School of Medicine, 1 Church Street #703, New Haven, CT, 06510, USA

    Kathleen A. Garrison

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Chawla, M., Garrison, K.A. Neurobiological Considerations for Tobacco Use Disorder. Curr Behav Neurosci Rep 5, 238–248 (2018). https://doi.org/10.1007/s40473-018-0168-3

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