Liver Repair and Regeneration in Transplant: State of the Art

Abstract

Purpose of Review

The liver is known for having the unusual capacity to regenerate itself following injury. Transplantation is necessarily associated with injury, cell death, and regeneration. The regenerative capacity of the liver is vital to the optimal outcomes of patients who undergo transplant.

Recent Findings

In this review, we will investigate the mechanisms, including cells and some of the major molecules and cytokines in this process. These will help to elucidate the importance of these molecules while at the same time demonstrating the complexity of this process. Finally, external factors which affect optimal regeneration of the liver will be discussed.

Summary

Several factors affect liver regeneration such as ischemic reperfusion injury, graft size, immunosuppression, donor age, steatosis, nutrition, and viral hepatitis. The conglomeration and consolidation of all this information is meant to provide the reader with a deeper picture of this process, while also serving to lay a foundation for ideas for further research in this field and consequently improve transplant outcomes.

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Hyslip, J., Martins, P.N. Liver Repair and Regeneration in Transplant: State of the Art. Curr Transpl Rep 7, 90–98 (2020). https://doi.org/10.1007/s40472-020-00269-z

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Keywords

  • Liver
  • Liver regeneration
  • Liver repair
  • Transplantation
  • Injury
  • Mechanisms