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Current Addiction Reports

, Volume 5, Issue 1, pp 72–85 | Cite as

Alcohol and Noncommunicable Disease Risk

  • Jürgen Rehm
  • Omer S. M. Hasan
  • Sameer Imtiaz
  • Charlotte Probst
  • Michael Roerecke
  • Kevin Shield
Alcohol (M Farrell and E Stockings, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Alcohol

Abstract

Purpose of Review

Alcohol use is a major risk factor for noncommunicable diseases (NCDs), annually causing more than 1.8 million deaths, and approximately 52 million disability-adjusted life years lost globally. This review examines the relationship between alcohol use and NCDs in the context of current United Nations (UN) and World Health Organization (WHO) initiatives to reduce the burden of NCDs as well as the resulting policy implications.

Recent Findings

The importance of alcohol as a major risk factor for NCDs is evidenced by its inclusion as one of only four behavioral risk factors (tobacco use, unhealthy diet, physical inactivity, and harmful use of alcohol) into the World Health Organization’s Global Action Plan for the Prevention and Control of NCDs. Alcohol use also plays a major role in other strategic initiatives of the UN and WHO.

Summary

While these inclusions help enable policy measures to reduce harmful alcohol use, the Global NCD Action Plan in general disregards many diseases and injuries caused by alcohol, most notably liver cirrhosis and all mental disorders. Furthermore, the Global NCD Action Plan also fails to highlight interactions between risk factors; however, there is strong epidemiological evidence of the differential harms caused by alcohol use between poverty/socioeconomic strata. Thus, future policy plans should explicitly include consideration of health inequalities.

Keywords

Alcohol Noncommunicable disease Policy Risk factor Liver cirrhosis 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

40429_2018_189_MOESM1_ESM.docx (19 kb)
ESM 1 (DOCX 19.3 kb)

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    •• World Health Organization. Global status report on alcohol and health. Geneva, Switzerland: World Health Organization; 2014. Most recent monitoring report on alcohol, alcohol control policy and health with detailed profiles on country level. Google Scholar
  2. 2.
    GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1345–422.  https://doi.org/10.1016/S0140-6736(17)32366-8.PubMedCentralCrossRefGoogle Scholar
  3. 3.
    • Rehm J, Imtiaz S. Alcohol consumption as a risk factor for global burden of disease. A narrative review. Subst Abuse Treat Prev Policy. 2016;11(1):37.  https://doi.org/10.1186/s13011-016-0081-2. Overview of alcohol use as a risk factor in comparative risk assessements with the Global Burden of Disease and Injury Study and WHO monitoring efforts. PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol use disorders. Lancet. 2009;373(9682):2223–33.  https://doi.org/10.1016/S0140-6736(09)60746-7.PubMedCrossRefGoogle Scholar
  5. 5.
    •• Rehm J, Gmel GE, Gmel G, OSM H, Imtiaz S, Popova S, et al. The relationship between different dimensions of alcohol use and the burden of disease—an update. Addiction. 2017;112(6):968–1001.  https://doi.org/10.1111/add.13757. Most up-to-date review on the epidemiological status quo of alcohol and different disease endpoints. Covers a) causality of relation, b) main mechanisms, and c) type of risk relationships. Basis for WHO Global Status Reports. PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Lutz W, Sanderson W, Scherbov S. The coming acceleration of global population ageing. Nature. 2008;451(7179):716–9.PubMedCrossRefGoogle Scholar
  7. 7.
    World Health Organization. Global action plan for the prevention and control of NCDs 2013-2020. Geneva, Switzerland: World Health Organization; 2013.Google Scholar
  8. 8.
    •• United Nations. Sustainable development goals. 2017. Available from: http://www.un.org/sustainabledevelopment/sustainable-development-goals/. Accessed: 10/19/2017 Most important collection of objectives of the United Nations not limited to health. Google Scholar
  9. 9.
    International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans: alcohol consumption and ethyl carbamate. Lyon, France: International Agency for Research on Cancer; 2010.Google Scholar
  10. 10.
    International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans 100E Personal habits and indoor combustions. Lyon, France: International Agency for Research on Cancer; 2012.Google Scholar
  11. 11.
    Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015;112(3):580–93.  https://doi.org/10.1038/bjc.2014.579.
  12. 12.
    Corrao G, Bagnardi V, Zambon A, La Vecchia C. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med. 2004;38(5):613–9.  https://doi.org/10.1016/j.ypmed.2003.11.027.PubMedCrossRefGoogle Scholar
  13. 13.
    Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res. 2016;40(6):1166–81.  https://doi.org/10.1111/acer.13071.PubMedCrossRefGoogle Scholar
  14. 14.
    Howard AA, Arnsten JH, Gourevitch MN. Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med. 2004;140(3):211–9.  https://doi.org/10.7326/0003-4819-140-6-200403160-00011.PubMedCrossRefGoogle Scholar
  15. 15.
    Baliunas D, Taylor B, Irving H, Roerecke M, Patra J, Mohapatra S, et al. Alcohol as a risk factor for type 2 diabetes—a systematic review and meta-analysis. Diabetes Care. 2009;32(11):2123–32.  https://doi.org/10.2337/dc09-0227.PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Collins MA, Neafsey EJ, Mukamal KJ, Gray MO, Parks DA, Das DK, et al. Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. Alcohol Clin Exp Res. 2009;33(2):206–19.  https://doi.org/10.1111/j.1530-0277.2008.00828.x.
  17. 17.
    Ridley NJ, Draper B, Withall A. Alcohol-related dementia: an update of the evidence. Alzheimers Res Ther. 2013;5(1):3.  https://doi.org/10.1186/alzrt157.PubMedPubMedCentralCrossRefGoogle Scholar
  18. 18.
    Daulatzai MA. “Boomerang neuropathology” of late-onset Alzheimer’s disease is shrouded in harmful “BDDS”: breathing, diet, drinking, and sleep during aging. Neurotox Res. 2015;28(1):55–93.  https://doi.org/10.1007/s12640-015-9528-x.PubMedCrossRefGoogle Scholar
  19. 19.
    Schwarzinger M, Pollock BG, Hasan OSM, Dufouil C, Rehm J. Contribution of alcohol use disorders to the burden of dementia in France 2008–2013: a nationwide retrospective cohort study. Lancet Public Health. 2018.Google Scholar
  20. 20.
    Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health. 2014;24(14):643.  https://doi.org/10.1186/1471-2458-14-643. CrossRefGoogle Scholar
  21. 21.
    Rehm J, Room R, Monteiro M, Gmel G, Graham K, Rehn N, et al. Alcohol use. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Geneva, Switzerland: World Health Organization; 2004. p. 959–1109.Google Scholar
  22. 22.
    Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011;106(5):906–14.  https://doi.org/10.1111/j.1360-0443.2010.03351.x.PubMedCrossRefGoogle Scholar
  23. 23.
    Foulds JA, Adamson SJ, Boden JM, Williman JA, Mulder RT. Depression in patients with alcohol use disorders: systematic review and meta-analysis of outcomes for independent and substance-induced disorders. J Affect Disord. 2015;1(185):47–59.  https://doi.org/10.1016/j.jad.2015.06.024.CrossRefGoogle Scholar
  24. 24.
    Fergusson DM, Boden JM, Horwood LJ. Tests of causal links between alcohol abuse or dependence and major depression. Arch Gen Psychiatry. 2009;66(3):260–6.  https://doi.org/10.1001/archgenpsychiatry.2008.543.PubMedCrossRefGoogle Scholar
  25. 25.
    Bartolomei F. Epilepsy and alcohol. Epileptic Disord. 2006;8:S72–S8.Google Scholar
  26. 26.
    Barclay GA, Barvour J, Stewart S, Day CP, Gilvarry E. Adverse physical effects of alcohol misuse. Adv Psychiatr Treat. 2008;14(02):139–51.  https://doi.org/10.1192/apt.bp.105.001263.CrossRefGoogle Scholar
  27. 27.
    Leach JP, Mohanraj R, Borland W. Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. Epilepsia. 2012;53(Suppl 4):48–57.PubMedCrossRefGoogle Scholar
  28. 28.
    Samokhvalov AV, Irving H, Mohapatra S, Rehm J. Alcohol consumption, unprovoked seizures and epilepsy: a systematic review and meta-analysis. Epilepsia. 2010;51(7):1177–84.  https://doi.org/10.1111/j.1528-1167.2009.02426.x.PubMedCrossRefGoogle Scholar
  29. 29.
    Puddey IB, Beilin LJ. Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol. 2006;33(9):847–52.  https://doi.org/10.1111/j.1440-1681.2006.04452.x.PubMedCrossRefGoogle Scholar
  30. 30.
    O'Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJ, Lavie CJ. Alcohol and cardiovascular health: the dose makes the poison...or the remedy. Mayo Clin Proc. 2014;89(3):382–93.  https://doi.org/10.1016/j.mayocp.2013.11.005.PubMedCrossRefGoogle Scholar
  31. 31.
    Xin X, He J, Frontini MG, Ogden LG, Motsamai OJ, Whelton PK. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2001;38(5):1112–7.  https://doi.org/10.1161/hy1101.093424.PubMedCrossRefGoogle Scholar
  32. 32.
    Roerecke M, Kaczorowski J, Tobe SW, Gmel G, OSM H, Rehm J. The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis of trial data. Lancet. Public Health. 2017;2:e108–e20.  https://doi.org/10.1016/S2468-2667(17)30003-8. PubMedGoogle Scholar
  33. 33.
    Rehm J, Sherk A, Shield KD, Gmel G. Risk relations between alcohol use and non-injury causes of death. 2017. Available from: http://www.camh.ca/en/research/news_and_publications/reports_and_books/Documents/CAMH-Risk-relations-between-alcohol-use-and-non-injury-causes-of-death-Sept2017.pdf. Accessed: 10/04/2017.
  34. 34.
    Rehm J, Roerecke M. Cardiovascular effects of alcohol consumption. Trends Cardiovasc Med. 2017;27(8):534–8.  https://doi.org/10.1016/j.tcm.2017.06.002.PubMedCrossRefGoogle Scholar
  35. 35.
    Mukamal KJ, Rimm EB. Alcohol’s effects on the risk for coronary heart disease. Alcohol Res Health. 2001;25:255–61.PubMedGoogle Scholar
  36. 36.
    Roerecke M, Rehm J. Alcohol consumption, drinking patterns, and ischemic heart disease: a narrative review of meta-analyses and a systematic review and meta-analysis of the impact of heavy drinking occasions on risk for moderate drinkers. BMC Med. 2014;12(1):182.  https://doi.org/10.1186/s12916-014-0182-6.PubMedPubMedCentralCrossRefGoogle Scholar
  37. 37.
    Rehm J, Shield KD, Roerecke M, Gmel G. Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview. BMC Public Health. 2016;16(1):363.  https://doi.org/10.1186/s12889-016-3026-9.PubMedPubMedCentralCrossRefGoogle Scholar
  38. 38.
    Iacovoni A, De Maria R, Gavazzi A. Alcoholic cardiomyopathy. J Cardiovasc Med. 2010;11(12):884–92.  https://doi.org/10.2459/JCM.0b013e32833833a3.CrossRefGoogle Scholar
  39. 39.
    George A, Figueredo VM. Alcoholic cardiomyopathy: a review. J Card Fail. 2011;17(10):844–9.  https://doi.org/10.1016/j.cardfail.2011.05.008.PubMedCrossRefGoogle Scholar
  40. 40.
    Rehm J, Hasan OSM, Imtiaz S, Neufeld M. Quantifying the contribution of alcohol to cardiomyopathy: a systematic review. Alcohol. 2017;61:9–15.  https://doi.org/10.1016/j.alcohol.2017.01.011.PubMedCrossRefGoogle Scholar
  41. 41.
    Manthey J, Imtiaz S, Neufeld J, Rylett M, Rehm J. Quantifying the global contribution of alcohol consumption to cardiomyopathy. Popul Health Metr. 2017;15(1):20.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    Rosenqvist M. Alcohol and cardiac arrhythmias. Alcohol Clin Exp Res. 1998;22(7 Suppl):318s–22s.  https://doi.org/10.1111/j.1530-0277.1998.tb04385.x.PubMedCrossRefGoogle Scholar
  43. 43.
    Rosenberg MA, Mukamal KJ. The estimated risk of atrial fibrillation related to alcohol consumption. J Atr Fibrillation. 2012;5(1):83–92.Google Scholar
  44. 44.
    Samokhvalov AV, Irving HM, Rehm J. Alcohol as a risk factor for atrial fibrillation: a systematic review and meta-analysis. Eur J Cardiov Prev R. 2010;17(6):706–12.  https://doi.org/10.1097/HJR.0b013e32833a1947.CrossRefGoogle Scholar
  45. 45.
    Puddey IB, Rakic V, Dimmitt SB, Beilin LJ. Influence of pattern of drinking on cardiovascular disease and cardiovascular risk factors—a review. Addiction. 1999;94(5):649–63.  https://doi.org/10.1046/j.1360-0443.1999.9456493.x.PubMedCrossRefGoogle Scholar
  46. 46.
    Mazzaglia G, Britton R, Altmann DR, Chenet L. Exploring the relationship between alcohol consumption and non-fatal or fatal stroke: a systematic review. Addiction. 2001;96(12):1743–56.  https://doi.org/10.1046/j.1360-0443.2001.961217434.x.PubMedCrossRefGoogle Scholar
  47. 47.
    Patra J, Taylor B, Irving H, Roerecke M, Baliunas D, Mohapatra S, et al. Alcohol consumption and the risk of morbidity and mortality for different stroke types—a systematic review and meta-analysis. BMC Public Health. 2010;10(1):258.  https://doi.org/10.1186/1471-2458-10-258.
  48. 48.
    Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141(5):1572–85.  https://doi.org/10.1053/j.gastro.2011.09.002.PubMedPubMedCentralCrossRefGoogle Scholar
  49. 49.
    Rehm J, Taylor B, Mohapatra S, Irving H, Baliunas D, Patra J, et al. Alcohol as a risk factor for liver cirrhosis—a systematic review and meta-analysis. Drug Alcohol Rev. 2010;29(4):437–45.  https://doi.org/10.1111/j.1465-3362.2009.00153.x.PubMedCrossRefGoogle Scholar
  50. 50.
    Tseng M, Everhart JE, Sandler RS. Dietary intake and gallbladder disease: a review. Public Health Nutr. 1999;2(2):161–72.PubMedCrossRefGoogle Scholar
  51. 51.
    Shabanzadeh DM, Sørensen LT, Jørgensen T. Determinants for gallstone formation - a new data cohort study and a systematic review with meta-analysis. Scand J Gastroenterol. 2016;51(10):1239–48.  https://doi.org/10.1080/00365521.2016.1182583.PubMedCrossRefGoogle Scholar
  52. 52.
    Braganza J, Lee S, McCloy R, McMahon M. Chronic pancreatitis. Lancet. 2011;377(9772):1184–97.  https://doi.org/10.1016/S0140-6736(10)61852-1.PubMedCrossRefGoogle Scholar
  53. 53.
    Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252–61.  https://doi.org/10.1053/j.gastro.2013.01.068.PubMedPubMedCentralCrossRefGoogle Scholar
  54. 54.
    Lankisch P, Apte M, Banks P. Acute pancreatitis. Lancet. 2015;386(9988):85–96.  https://doi.org/10.1016/S0140-6736(14)60649-8.PubMedCrossRefGoogle Scholar
  55. 55.
    Majumder S, Chari ST. Chronic pancreatitis. Lancet. 2016;387(10031):1957–66.  https://doi.org/10.1016/S0140-6736(16)00097-0.PubMedCrossRefGoogle Scholar
  56. 56.
    Samokhvalov AV, Rehm J, Roerecke M. Alcohol consumption as a risk factor for acute and chronic pancreatitis: a systematic review and a series of meta-analyses. EBioMedicine. 2015;2(12):1996–2002.  https://doi.org/10.1016/j.ebiom.2015.11.023.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    International Agency for Research on Cancer, World Health Organization. IARC Monogr Eval Carcinog Risks Hum. 2016. Available from: http://monographs.iarc.fr/ENG/Preamble/currentb6evalrationale0706.php. Accessed: 09/05/2017.
  58. 58.
    World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013–2020. 2013. Available from: http://apps.who.int/iris/bitstream/10665/94384/1/9789241506236_eng.pdf. Accessed: 10/04/2017.Google Scholar
  59. 59.
    World Health Organization. Global strategy to reduce the harmful use of alcohol. Geneva, Switzerland: World Health Organization; 2010.Google Scholar
  60. 60.
    Kontis V, Mathers CD, Rehm J, Stevens GA, Shield KD, Bonita R, et al. Contribution of six risk factors to achieving the “25×25” NCD mortality reduction target. Lancet. 2014;384(9941):427–37.  https://doi.org/10.1016/S0140-6736(14)60616-4. PubMedCrossRefGoogle Scholar
  61. 61.
    Kontis V, Mathers CD, Bonita R, Stevens GA, Rehm J, Shield KD, et al. Regional contributions of six preventable risk factors to achieving the 25×25 non-communicable disease mortality reduction target: a modelling study. Lancet. Glob Health. 2015;3(12):e746–e57.  https://doi.org/10.1016/S2214-109X(15)00179-5. Google Scholar
  62. 62.
    GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1260–344.  https://doi.org/10.1016/s0140-6736(17)32130-x.CrossRefGoogle Scholar
  63. 63.
    World Health Organization. World health report 2001: mental health: new understanding, new hope. Geneva, Switzerland: World Health Organization; 2001.Google Scholar
  64. 64.
    Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382(9904):1575–86.  https://doi.org/10.1016/S0140-6736(13)61611-6.
  65. 65.
    Lopez AD, Williams TN, Levin A, Tonelli M, Singh JA, Burney PGJ, et al. Remembering the forgotten non-communicable diseases. BMC Med. 2014;12(1):200.  https://doi.org/10.1186/s12916-014-0200-8.
  66. 66.
    Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol. 2013;58(3):593–608.  https://doi.org/10.1016/j.jhep.2012.12.005.PubMedCrossRefGoogle Scholar
  67. 67.
    Case A, Deaton A. Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci U S A. 2015;112(49):15078–83.  https://doi.org/10.1073/pnas.1518393112.PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Imtiaz S, Probst C, Rehm J. Substance use and population life expectancy in the United States: interactions with health inequalities and implications for policy. Drug Alcohol Rev. in press.Google Scholar
  69. 69.
    Williams R, Aspinall R, Bellis M, Camps-Walsh G, Cramp M, Dhawan A, et al. Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis. Lancet. 2014;384(9958):1953–97.  https://doi.org/10.1016/s0140-6736(14)61838-9.
  70. 70.
    Room R, Ferris J, Laslett AM, Livingston M, Mugavin J, Wilkinson C. The drinker’s effect on the social environment: a conceptual framework for studying alcohol’s harm to others. Int J Environ Res Public Health. 2010;7(4):1855–71.  https://doi.org/10.3390/ijerph7041855.PubMedPubMedCentralCrossRefGoogle Scholar
  71. 71.
    Navarro HJ, Doran CM, Shakeshaft AP. Measuring costs of alcohol harm to others: a review of the literature. Drug Alcohol Depend. 2010;114(2–3):87–99.  https://doi.org/10.1016/j.drugalcdep.2010.11.009.PubMedGoogle Scholar
  72. 72.
    Connor J, Casswell S. Alcohol-related harm to others in New Zealand: evidence of the burden and gaps in knowledge. N Z Med J. 2012;125(1360):11–27.PubMedGoogle Scholar
  73. 73.
    Murray CJL. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Org. 1994;72(3):429–45.PubMedPubMedCentralGoogle Scholar
  74. 74.
    Murray CJL. Rethinking DALYs. In: CJL M, Lopez A, editors. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Boston: Harvard School of Public Health; 1996. p. 1–98.Google Scholar
  75. 75.
    World Health Organization. NCD Global Monitoring Framework: Ensuring progress on noncommunicable diseases in countries. 2017. Available from: http://www.who.int/nmh/global_monitoring_framework/en/. Accessed: 10/15/2017.
  76. 76.
    Knott C, Bell S, Britton A. Alcohol consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of more than 1.9 million individuals from 38 observational studies. Diabetes Care. 2015;38(9):1804–12.  https://doi.org/10.2337/dc15-0710.PubMedCrossRefGoogle Scholar
  77. 77.
    Chikritzhs T, Stockwell T, Naimi T, Andreasson S, Dangardt F, Liang W. Has the leaning tower of presumed health benefits from moderate alcohol use finally collapsed? Addiction. 2015;110(5):726–7.  https://doi.org/10.1111/add.12828.PubMedCrossRefGoogle Scholar
  78. 78.
    Agarwal DP. Cardioprotective effects of light-moderate consumption of alcohol: a review of putative mechanisms. Review Alcohol Alcohol. 2002;37(5):409–15.  https://doi.org/10.1093/alcalc/37.5.409.PubMedCrossRefGoogle Scholar
  79. 79.
    Brien SE, Ronksley PE, Turner BJ, Mukamal KJ, Ghali WA. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ. 2011;342(feb22 1):d636.  https://doi.org/10.1136/bmj.d636.PubMedPubMedCentralCrossRefGoogle Scholar
  80. 80.
    Ezzati M, Lopez A, Rodgers A, Murray CJL. Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors. Geneva, Switzerland: world health. Organization. 2004;Google Scholar
  81. 81.
    Murray CJL, Ezzati M, Lopez A, Rodgers A, Vander Hoorn S. Comparative quantification of health risks conceptual framework and methodological issues. Popul Health Metr. 2003;1(1):1–20.PubMedPubMedCentralCrossRefGoogle Scholar
  82. 82.
    Ray RM. Comparative risk assessment. 2008. Available from: http://onlinelibrary.wiley.com/doi/10.1002/9780470061596.risk0040/abstract. Accessed: 10/20/2017.Google Scholar
  83. 83.
    Rehm J, Monteiro M, Room R, Gmel G, Jernigan D, Frick U, et al. Steps towards constructing a global comparative risk analysis for alcohol consumption: determining indicators and empirical weights for patterns of drinking, deciding about theoretical minimum, and dealing with different consequences. Eur Addict Res. 2001;7(3):138–47.  https://doi.org/10.1159/000050731.
  84. 84.
    Rehm J, Taylor B, Patra J, Gmel G. Avoidable burden of disease: conceptual and methodological issues in substance abuse epidemiology. Int J Methods Psychiatr Res. 2006;15(4):181–91.PubMedCrossRefGoogle Scholar
  85. 85.
    Shin MJ, Cho YH, Smith D. Alcohol consumption, aldehyde dehydrogenase 2 gene polymorphisms, and cardiovascular health in Korea. Yonsei Med J. 2017;58(4):689–96.  https://doi.org/10.3349/ymj.2017.58.4.689.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Roerecke M, Shield KD, Higuchi S, Yoshimura A, Larsen E, Rehm MX, et al. Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses. Bull World Health Org. 2015;93(5):329–8c.PubMedPubMedCentralCrossRefGoogle Scholar
  87. 87.
    Zintzaras E, Stefanidis I, Santos M, Vidal F. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology (Baltimore, Md). 2006;43(2):352–61.CrossRefGoogle Scholar
  88. 88.
    Rehm J, Anderson P, Gual A, Kraus L, Marmet S, Room R, et al. The tangible common denominator of substance use disorders: a reply to commentaries to Rehm et al. (2013). Alcohol Alcohol. 2014;49(1):118–22.  https://doi.org/10.1093/alcalc/agt171. PubMedCrossRefGoogle Scholar
  89. 89.
    Rehm J, Marmet S, Anderson P, Gual A, Kraus L, Nutt DJ, et al. Defining substance use disorders: do we really need more than heavy use? Alcohol Alcohol. 2013;48(6):633–40.  https://doi.org/10.1093/alcalc/agt127.
  90. 90.
    Paton A. ABC of alcohol: alcohol in the body. BMJ. 2005;330(7482):85–7.  https://doi.org/10.1136/bmj.330.7482.85.PubMedPubMedCentralCrossRefGoogle Scholar
  91. 91.
    Bosron WF, Magnes LJ, Li TK. Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase. Biochemistry. 1983;22(8):1852–7.  https://doi.org/10.1021/bi00277a017.PubMedCrossRefGoogle Scholar
  92. 92.
    Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ. 2014;349(jul10 6):g4164.  https://doi.org/10.1136/bmj.g4164.
  93. 93.
    Bosron WF, Li TK. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology. 1986;6(3):502–10.  https://doi.org/10.1002/hep.1840060330.PubMedCrossRefGoogle Scholar
  94. 94.
    Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, et al. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol. 2004;159(1):1–16.  https://doi.org/10.1093/aje/kwh003.
  95. 95.
    Eng MY, Luczak SE, Wall TL. ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. Alcohol Res Health. 2007;30(1):22–7.PubMedPubMedCentralGoogle Scholar
  96. 96.
    Quertemont E. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol Psychiatry. 2004;9(6):570–81.  https://doi.org/10.1038/sj.mp.4001497.PubMedCrossRefGoogle Scholar
  97. 97.
    Møller P, Wallin H. Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product. Mutat Res Rev Mutat Res. 1998;410(3):271–90.  https://doi.org/10.1016/S1383-5742(97)00041-0.CrossRefGoogle Scholar
  98. 98.
    Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993;90(17):7915–22.  https://doi.org/10.1073/pnas.90.17.7915.PubMedPubMedCentralCrossRefGoogle Scholar
  99. 99.
    Seitz HK, Becker P. Alcohol metabolism and cancer risk. Alcohol Res Health. 2007;30(1):38–47.PubMedPubMedCentralGoogle Scholar
  100. 100.
    Hayashi SI, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem. 1991;110(4):559–65.  https://doi.org/10.1093/oxfordjournals.jbchem.a123619.PubMedCrossRefGoogle Scholar
  101. 101.
    Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer. 2000;87(5):734–40.  https://doi.org/10.1002/1097-0215(20000901)87:5<734::AID-IJC17>3.0.CO;2-E.PubMedCrossRefGoogle Scholar
  102. 102.
    Crabb DW, Edenberg HJ, Bosron WF, Li TK. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity: the inactive ALDH2*2 allele is dominant. J Clin Invest. 1989;83(1):314–6.  https://doi.org/10.1172/JCI113875.PubMedPubMedCentralCrossRefGoogle Scholar
  103. 103.
    Kruman II, Fowler AK. Impaired one carbon metabolism and DNA methylation in alcohol toxicity. J Neurochem. 2014;129(5):770–80.  https://doi.org/10.1111/jnc.12677.PubMedCrossRefGoogle Scholar
  104. 104.
    Taioli E, Garza MA, Ahn YO, Bishop DT, Bost J, Budai B, et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. Am J Epidemiol. 2009;170(10):1207–21.  https://doi.org/10.1093/aje/kwp275.
  105. 105.
    Qi X, Ma X, Yang X, Fan L, Zhang Y, Zhang F, et al. Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls. Breast Cancer Res Treat. 2010;123(2):499–506.  https://doi.org/10.1007/s10549-010-0773-7.
  106. 106.
    Taylor B, Irving HM, Baliunas D, Roerecke M, Patra J, Mohapatra S, et al. Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction. 2009;104(12):1981–90.  https://doi.org/10.1111/j.1360-0443.2009.02694.x.
  107. 107.
    Briasoulis A, Agarwal V, Messerli FH. Alcohol consumption and the risk of hypertension in men and women: a systematic review and meta-analysis. J Clin Hypertens. 2012;14(11):792–8.  https://doi.org/10.1111/jch.12008.CrossRefGoogle Scholar
  108. 108.
    Fuchs FD, Chambless LE, Whelton PK, Nieto FJ, Heiss G. Alcohol consumption and the incidence of hypertension: the Atherosclerosis Risk in Communities Study. Hypertension. 2001;37(5):1242–50.  https://doi.org/10.1161/01.HYP.37.5.1242.PubMedCrossRefGoogle Scholar
  109. 109.
    Halanych JH, Safford MM, Kertesz SG, Pletcher MJ, Kim YI, Person SD, et al. Alcohol consumption in young adults and incident hypertension: 20-year follow-up from the Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol. 2010;171(5):532–9.  https://doi.org/10.1093/aje/kwp417.
  110. 110.
    Sull JW, Yim SW, Cm N, Choi K, Ohr H. Binge drinking and hypertension on cardiovascular disease mortality in Korean men and women: a Kangwha cohort study. Stroke. 2010;41(10):2157–62.  https://doi.org/10.1161/STROKEAHA.110.586347.PubMedCrossRefGoogle Scholar
  111. 111.
    Murray RP, Ekuma O, Barnes GE. Drinking pattern as a predictor of cardiovascular harm: a longitudinal study using alternative drinking pattern measures. J Subst Abus. 2006;11(5):359–68.Google Scholar
  112. 112.
    MacMahon S. Alcohol consumption and hypertension. Hypertension. 1987;9(2):111–21.PubMedCrossRefGoogle Scholar
  113. 113.
    Moreira LB, Fuchs FD, Moraes RS, Bredemeier M, Duncan BB. Alcohol intake and blood pressure: the importance of time elapsed since last drink. J Hypertens. 1998;16(2):175–80.  https://doi.org/10.1097/00004872-199816020-00007.PubMedCrossRefGoogle Scholar
  114. 114.
    Puddey IB, Vandongen R, Beilin LJ, Rouse IL. Alcohol stimulation of renin release in man: its relation to the hemodynamic, electrolyte, and sympatho-adrenal responses to drinking. J Clin Endocrinol Metab. 1985;61(1):37–42.  https://doi.org/10.1210/jcem-61-1-37.PubMedCrossRefGoogle Scholar
  115. 115.
    Kupari M. Acute cardiovascular effects of ethanol A controlled non-invasive study. Br Heart J. 1983;49(2):174–82.PubMedPubMedCentralCrossRefGoogle Scholar
  116. 116.
    Riff DP, Jain AC, Doyle JT. Acute hemodynamic effects of ethanol on normal human volunteers. Am Heart J. 1969;78(5):592–7.  https://doi.org/10.1016/0002-8703(69)90510-9.PubMedCrossRefGoogle Scholar
  117. 117.
    Child JS, Kovick RB, Levisman JA, Pearce ML. Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade. Circulation. 1979;59(1):120–5.  https://doi.org/10.1161/01.CIR.59.1.120.PubMedCrossRefGoogle Scholar
  118. 118.
    Ireland MA, Vandongen R, Davidson L, Beilin LJ, Rouse IL. Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines. Clin Sci. 1984;66(6):643–8.  https://doi.org/10.1042/cs0660643.PubMedCrossRefGoogle Scholar
  119. 119.
    Grassi GM, Somers VK, Renk WS, Abboud FM, Mark AL. Effects of alcohol intake on blood pressure and sympathetic nerve activity in normotensive humans: a preliminary report. J Hypertens. 1989;7(6):S20–S1.  https://doi.org/10.1097/00004872-198900076-00007.CrossRefGoogle Scholar
  120. 120.
    Kawano Y. Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease. Hyptertens Res. 2010;33(3):181–91.  https://doi.org/10.1038/hr.2009.226.CrossRefGoogle Scholar
  121. 121.
    Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957–67.  https://doi.org/10.1016/S0140-6736(15)01225-8.
  122. 122.
    Wright JTJ, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103–16.  https://doi.org/10.1056/NEJMoa1511939.PubMedCrossRefGoogle Scholar
  123. 123.
    Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2016;387(10017):435–43.  https://doi.org/10.1016/s0140-6736(15)00805-3.
  124. 124.
    Huang C, Zhan J, Liu YJ, Li DJ, Wang SQ, He QQ. Association between alcohol consumption and risk of cardiovascular disease and all-cause mortality in patients with hypertension: a meta-analysis of prospective cohort studies. Mayo Clin Proc. 2014;89(9):1201–10.  https://doi.org/10.1016/j.mayocp.2014.05.014.PubMedCrossRefGoogle Scholar
  125. 125.
    Rehm J, Anderson P, Arbesu Prieto JA, Armstrong I, Aubin HJ, Bachmann M, et al. Towards new recommendations to reduce the burden of alcohol-induced hypertension in the European Union. BMC Med. 2017;15(1):173.  https://doi.org/10.1186/s12916-017-0934-1.PubMedPubMedCentralCrossRefGoogle Scholar
  126. 126.
    Taylor B, Rehm J. When risk factors combine: the interaction between alcohol and smoking for aerodigestive cancer, coronary heart disease, and traffic and fire injury. Addict Behav. 2006;31(9):1522–35.  https://doi.org/10.1016/j.addbeh.2005.11.008.PubMedCrossRefGoogle Scholar
  127. 127.
    Mukamal KJ. The effects of smoking and drinking on cardiovascular disease and risk factors. Alcohol Res Health. 2006;29(3):199–202.PubMedGoogle Scholar
  128. 128.
    Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7(8):599–612.  https://doi.org/10.1038/nrc2191.PubMedCrossRefGoogle Scholar
  129. 129.
    Anantharaman D, Marron M, Lagiou P, Samoli E, Ahrens W, Pohlabeln H, et al. Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncol. 2011;47(8):725–31.  https://doi.org/10.1016/j.oraloncology.2011.05.004.
  130. 130.
    Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, et al. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomark Prev. 2009;18(2):541–50.  https://doi.org/10.1158/1055-9965.epi-08-0347.CrossRefGoogle Scholar
  131. 131.
    Pelucchi C, Gallus S, Garavello W, Bosetti C, La Vecchia C. Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. Eur J Cancer Prev. 2008;17(4):340–4.  https://doi.org/10.1097/CEJ.0b013e3282f75e91.PubMedCrossRefGoogle Scholar
  132. 132.
    Zeka A, Gore R, Kriebel D. Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis. Cancer Causes Control. 2003;14(9):897–906.  https://doi.org/10.1023/B:CACO.0000003854.34221.a8.PubMedCrossRefGoogle Scholar
  133. 133.
    Swan GE, Carmelli D, Cardon LR. Heavy consumption of cigarettes, alcohol and coffee in male twins. J Stud Alcohol. 1997;58(2):182–90.  https://doi.org/10.15288/jsa.1997.58.182.PubMedCrossRefGoogle Scholar
  134. 134.
    • Mackenbach JP, Kulhánová I, Bopp M, Borrell C, Deboosere P, Kovács K, et al. Inequalities in alcohol-related mortality in 17 European countries: a retrospective analysis of mortality registers. PLoS Med. 2015;12(12):e1001909. Most important overview on the relationship between alcohol use and inequalities in mortality, albeit restricted to Europe. PubMedPubMedCentralCrossRefGoogle Scholar
  135. 135.
    Mackenbach JP, Kulhánová I, Menvielle G, Bopp M, Borrell C, Costa G, et al. Trends in inequalities in premature mortality: a study of 3.2 million deaths in 13 European countries. J Epidemiol Community Health. 2015;69(3):207–3217.  https://doi.org/10.1136/jech-2014-204319.
  136. 136.
    Probst C, Roerecke M, Behrendt S, Rehm J. Socioeconomic differences in alcohol-attributable mortality compared to all-cause mortality: a systematic review and meta-analysis. Int J Epidemiol. 2014;43(4):1314–27.  https://doi.org/10.1093/ije/dyu043.PubMedPubMedCentralCrossRefGoogle Scholar
  137. 137.
    Schmidt LA, Mäkelä P, Rehm J, Room R. Alcohol: equity and social determinants. In: Blas E, Kurup AS, editors. Equity, social determinants and public health programmes. Geneva, Switzerland: World Health Organization; 2010. p. 11–29.Google Scholar
  138. 138.
    Hosseinpoor AR, Bergen N, Kunst A, Harper S, Guthold R, Rekve D, et al. Socioeconomic inequalities in risk factors for non communicable diseases in low-income and middle-income countries: results from the World Health Survey. BMC Public Health. 2012;12Google Scholar
  139. 139.
    Grittner U, Kuntsche S, Gmel G, Bloomfield K. Alcohol consumption and social inequality at the individual and country levels-results from an international study. Eur J Pub Health. 2013;23(2):332–9.  https://doi.org/10.1093/eurpub/cks044.CrossRefGoogle Scholar
  140. 140.
    Collins SE. Associations between socioeconomic factors and alcohol outcomes. Alcohol Res. 2016;38(1):83.PubMedPubMedCentralGoogle Scholar
  141. 141.
    Allen L, William J, Townsend N, Mikkelsen B, Roberts N, Foster C, et al. Socioeconomic status and non-communicable disease behavioural risk factors in low-income and lower-middle-income countries: a systematic review. Lancet Global Health. 2017;5(3):e277-e89.CrossRefGoogle Scholar
  142. 142.
    Bloomfield K, Grittner U, Kramer S, Gmel G. Social inequalities in alcohol consumption and alcohol-related problems in the study countries of the EU concerted action ‘Gender, culture and alcohol problems: a multi-national study’. Alcohol Alcohol. 2006;41(Suppl.):i26-i36.Google Scholar
  143. 143.
    Katikireddi SV, Whitley E, Lewsey J, Gray L, Leyland AH. Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data. Lancet Public Health. 2017;2(6):e267–e76.  https://doi.org/10.1016/S2468-2667(17)30078-6.
  144. 144.
    Mäkelä P, Paljärvi T. Do consequences at a given pattern of drinking vary by socioeconomic group? A mortality and hospitalization follow-up of the Finnish drinking habits surveys. J Epidemiol Community Health. 2008;62:728–33.PubMedCrossRefGoogle Scholar
  145. 145.
    Jones L, Bates G, McCoy E, Bellis MA. Relationship between alcohol-attributable disease and socioeconomic status, and the role of alcohol consumption in this relationship: a systematic review and meta-analysis. BMC Public Health. 2015;18(15):400.  https://doi.org/10.1186/s12889-015-1720-7.CrossRefGoogle Scholar
  146. 146.
    Bellis MA, Hughes K, Nicholls J, Sheron N, Gilmore I, Jones L. The alcohol harm paradox: using a national survey to explore how alcohol may disproportionately impact health in deprived individuals. BMC Public Health. 2016;18(16):111.  https://doi.org/10.1186/s12889-016-2766-x. CrossRefGoogle Scholar
  147. 147.
    Stringhini S, Carmeli C, Jokela M, Avendaño M, Muennig P, Guida F, et al. Socioeconomic status and the 25 x 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women. Lancet. 2017;389(10075):1229–37.  https://doi.org/10.1016/s0140-6736(16)32380-7.
  148. 148.
    Sommer I, Griebler U, Mahlknecht P, Thaler K, Bouskill K, Gartlehner G, et al. Socioeconomic inequalities in non-communicable diseases and their risk factors: an overview of systematic reviews. BMC Public Health. 2015;15(1):914.  https://doi.org/10.1186/s12889-015-2227-y.
  149. 149.
    Di Cesare M, Khang YH, Asaria P, Blakely T, Cowan MJ, Farzadfar F, et al. Inequalities in non-communicable diseases and effective responses. Lancet. 2013;381(9866):585–97.  https://doi.org/10.1016/S0140-6736(12)61851-0.
  150. 150.
    Piketty T. Capital in the twenty-first century. Massachusetts, MA: Harvard University Press; 2014.  https://doi.org/10.4159/9780674369542.CrossRefGoogle Scholar
  151. 151.
    •• Milanović B. Global inequality. A new approach for the age of globalization. Cambridge, MA: Harfard University Press; 2016. Standard overiew text on historical development, current situation, and future prospectives of financial and other inequalities. CrossRefGoogle Scholar
  152. 152.
    World Economic Forum, World Health Organization. From burden to “best buys”: reducing the economic impact of non-communicable diseases in low- and middle-income countries. 2011. Available from: http://www.who.int/nmh/publications/best_buys_summary.pdf. Accessed: 07/17/17.
  153. 153.
    Chisholm D, Rehm J, van Ommeren M, Monteiro M. Reducing the global burden of hazardous alcohol use: a comparative cost-effectiveness analysis. J Stud Alcohol. 2004;65(6):782–93.  https://doi.org/10.15288/jsa.2004.65.782.PubMedCrossRefGoogle Scholar
  154. 154.
    Babor T, Caetano R, Casswell S, Edwards G, Giesbrecht N, Graham K, et al. Alcohol: no ordinary commodity. Research and public policy. 2nd ed. Oxford and London: Oxford University Press; 2010.  https://doi.org/10.1093/acprof:oso/9780199551149.001.0001.CrossRefGoogle Scholar
  155. 155.
    Anderson P, Chisholm D, Fuhr D. Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol. Lancet. 2009;373(9682):2234–46.  https://doi.org/10.1016/S0140-6736(09)60744-3.PubMedCrossRefGoogle Scholar
  156. 156.
    • Anderson P, Braddick F, Conrod P, Gual A, Hellman M, Matrai S, et al. The new governance of addictive substances and behaviours. Oxford, U.K.: Oxford University Press; 2017. Most recent and comprehensive overview of potential governance of addiction in modern high income countries with focus on Europe. CrossRefGoogle Scholar
  157. 157.
    Sornpaisarn B, Shield KD, Österberg E, Rehm J. Resource tool on alcohol taxation and pricing policies. Geneva, Switzerland: World Health Organization; 2017.Google Scholar
  158. 158.
    Purshouse CR, Meier PS, Brennan A, Taylor KB, Rafia R. Estimated effect of alcohol pricing policies on health and health economic outcomes in England: an epidemiological model. Lancet. 2010;375(9723):1355–64.  https://doi.org/10.1016/S0140-6736(10)60058-X.PubMedCrossRefGoogle Scholar
  159. 159.
    Holmes J, Meng Y, Meier PS, Brennan A, Angus C, Campbell-Burton A, et al. Effects of minimum unit pricing for alcohol on different income and socioeconomic groups: a modelling study. Lancet. 2014;383(9929):1655–64.  https://doi.org/10.1016/S0140-6736(13)62417-4.
  160. 160.
    Rehm J, Lachenmeier DW, Jané Llopis E, Imtiaz S, Anderson P. Evidence of reducing ethanol content in beverages to reduce harmful use of alcohol. Lancet Gastroenterol Hepatol. 2016;1(9):78–83.  https://doi.org/10.1016/S2468-1253(16)30013-9.PubMedCrossRefGoogle Scholar
  161. 161.
    Rehm J, Anderson P, Fischer B, Gual A, Room R. Policy implications of marked reversals of population life expectancy caused by substance use. BMC Med. 2016;14(1):42.  https://doi.org/10.1186/s12916-016-0590-x.PubMedPubMedCentralCrossRefGoogle Scholar
  162. 162.
    United Nations. Goal 10: reduce inequality within and among countries. 2017. Available from: http://www.un.org/sustainabledevelopment/inequality/. Accessed: 10/19/2017.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018
corrected publication March/2018

Authors and Affiliations

  • Jürgen Rehm
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Omer S. M. Hasan
    • 1
    • 5
  • Sameer Imtiaz
    • 1
    • 3
  • Charlotte Probst
    • 1
    • 6
  • Michael Roerecke
    • 1
    • 5
  • Kevin Shield
    • 1
    • 5
  1. 1.Institute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH)TorontoCanada
  2. 2.Campbell Family Mental Health Research Institute, CAMHTorontoCanada
  3. 3.Institute of Medical Science (IMS)University of TorontoTorontoCanada
  4. 4.Department of PsychiatryUniversity of TorontoTorontoCanada
  5. 5.Dalla Lana School of Public HealthUniversity of TorontoTorontoCanada
  6. 6.Institute for Clinical Psychology and PsychotherapyTU DresdenDresdenGermany

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