Skip to main content

Advertisement

Log in

A case of severe NSAID exacerbated respiratory disease (NERD) following a dental procedure in a child

  • Case Report
  • Published:
European Archives of Paediatric Dentistry Aims and scope Submit manuscript

Abstract

Background

An allergic reaction following a dental procedure is a rare event. A local anaesthetic (LA) may initially be suspected as a causative agent but allergy to dental LA solutions is extremely rare.

Case report

This report concerns a 13 year old child who underwent dental treatment and was exposed to Lignospan Special® LA, mouthwash, latex gloves, ibuprofen medication, and a Magnum® (almond) ice cream all within 45 min. He subsequently developed acute symptoms of nasal rhinorrhoea, facial flushing, peri-orbital and lip angioedema, followed by throat tightness and wheeze (respiratory compromise). His acute reaction was treated by his medical practitioner with oral anti-histamines, steroid and nebulised salbutamol. The child was referred to a local allergist. The child underwent detailed allergic investigations including skin prick tests, blood tests, incremental local anaesthetic challenge and ibuprofen challenge. The patient was diagnosed with NSAID exacerbated respiratory disease (NERD), a hypersensitivity reaction to ibuprofen.

Follow-up

The patient was advised to avoid NSAIDs and to wear a medic-alert (allergy) bracelet. A detailed written report was sent to the patient’s dentist and GP.

Conclusions

In the context of a suspected reaction post dental procedure, local anaesthetic should be considered a possible allergen but other important considerations include analgesics, antibiotics, and latex. All genuine allergic reactions need to be investigated. This report highlights NERD as a possible adverse outcome following dental treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baker L, Hourihane JO. Latex allergy; two educational cases. Pediatr Allergy Immunol. 2008;19(6):477–81.

    Article  PubMed  Google Scholar 

  • Calderon AL, Diot N, Benatir F, et al. Immediate allergic cross-reactivity to levobupivacaine and ropivacaine. Anaesthesia. 2013;68:203.

    Article  PubMed  Google Scholar 

  • Chandler MJ, Grammer LC, Patterson R. Provocative challenge with local anesthetics in patients with a prior history of reaction. J Allergy Clin Immunol. 1987;79:883.

    Article  PubMed  Google Scholar 

  • Chiu CY, Lin TY, Hsia SH, et al. Systemic anaphylaxis following local lidocaine administration during a dental procedure. Pediatr Emerg Care. 2004;20:178.

    Article  PubMed  Google Scholar 

  • Conaghan PG. A turbulent decade for NSAIDS: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatol Int. 2012;32:1491–502.

    Article  PubMed  Google Scholar 

  • Cuesta-Herranz J, de las Heras M, Fernandez M, et al. Allergic reaction caused by local anesthetic agents belonging to the amide group. J Allergy Clin Immunol. 1997;99:427.

    Article  PubMed  Google Scholar 

  • deShazo RD, Nelson HS. An approach to the patient with a history of local anesthetic hypersensitivity: experience with 90 patients. J Allergy Clin Immunol. 1979;63:387.

    Article  PubMed  Google Scholar 

  • Gall H, Kaufmann R, Kalveram CM. Adverse reactions to local anesthetics: analysis of 197 cases. J Allergy Clin Immunol. 1996;97:933.

    Article  PubMed  Google Scholar 

  • Goodman EJ, Morgan MJ, Johnson PA, et al. Cephalosporins can be given to penicillin allergic patients who do not exhibit an anaphylactic response. J Clin Anesth. 2001;13:561–4.

    Article  PubMed  Google Scholar 

  • Haugen RN, Brown CW. Case reports: type I hypersensitivity to lidocaine. J Drugs Dermatol. 2007;6:1222.

    PubMed  Google Scholar 

  • Kowalski ML, Asero R, Bavbek S, et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti inflammatory drugs. Allergy. 2013;68:1219–32.

    Article  PubMed  Google Scholar 

  • Kowalski ML, Makowska JS, Blanca M, et al. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDS)– classification, diagnosis and management: review of the EAACI/ENDA and GA2LEN/HANNA. Allergy. 2011;66:818–29.

    Article  PubMed  Google Scholar 

  • McClimon B, Rank M, Li J. The predictive value of skin testing in the diagnosis of local anesthetic allergy. Allergy Asthma Proc. 2011;32:95–8.

    Article  PubMed  Google Scholar 

  • Morais-Almeida M, Gaspar A, Marinho S, et al. Allergy to local anesthetics of the amide group with tolerance to procaine. Allergy. 2003;58:827.

    Article  PubMed  Google Scholar 

  • Sambrook PJ, Smith W, Elijah J, et al. Severe adverse reactions to dental local anaesthetics: systemic reactions. Aust Dent J. 2011;56:148–53.

    Article  PubMed  Google Scholar 

  • Sampson HA, Ho DG. Relationship between food-specific IgE concentration and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100(4):444–51.

    Article  PubMed  Google Scholar 

  • Solensky R, Kahn DA. Drug allergy: an updated practise parameter. Ann Allergy Asthma Immunol. 2010;105:259–73.

    Article  Google Scholar 

  • Wang J. Management of the patient with multiple food allergies. Curr Allergy Asthma Rep. 2010;10(4):271–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Warrington RJ, McPhillips S. Allergic reaction to local anesthetic agents of the amide group. J Allergy clin Immunol. 1997;100:855.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G. King.

Ethics declarations

Funding

There was no funding received by the authors for this case report.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This case report does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in this case report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

King, G., Byrne, A. & Fleming, P. A case of severe NSAID exacerbated respiratory disease (NERD) following a dental procedure in a child. Eur Arch Paediatr Dent 17, 277–281 (2016). https://doi.org/10.1007/s40368-016-0233-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40368-016-0233-0

Keywords

Navigation