Low Density Lipoprotein (LDL) Cholesterol as a Causal Role for Atherosclerotic Disease: Potential Role of PCSK9 Inhibitors

  • Rita Del PintoEmail author
  • Davide Grassi
  • Giuliana Properzi
  • Giovambattista Desideri
  • Claudio Ferri
Review article


Proprotein convertase subtilisin/kexin type 9 (PCSK9)-related discoveries of the turn of the century have translated into substantial novelty in dyslipidemia treatment in the last 5 years. With chronic preventable atherosclerotic cardiovascular diseases (ASCVD) representing an epidemic of morbidity and mortality worldwide, low-density lipoprotein cholesterol (LDL-c) reduction represents a public health priority. By overcoming two major statin-related issues, namely intolerance and ineffectiveness, PCSK9 inhibitors have offered a safe and effective option in selected clinical settings where LDL-c reduction is required. Herein, we recapitulate recent findings, clinical applications, and ASCVD prevention potential of PCSK9 inhibition, with focus on anti-PCSK9 monoclonal antibodies, evolocumab and alirocumab.


Atherosclerotic plaque Cardiovascular diseases Cholesterol, LDL Proprotein convertases, subtilisin–kexin family Antibodies, monoclonal Anticholesteremic agents 


Author contributions

RDP and CF conceived the review. RDP, DG, GP, GD and CF drafted the manuscript. GD and CF supervised the manuscript drafting. All the authors read and commented on the manuscript and gave their final approval to the submitted version of the manuscript.

Compliance with Ethical Standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Italian Society of Hypertension 2019

Authors and Affiliations

  1. 1.Department of Life, Health and Environmental SciencesSan Salvatore Hospital, University of L’AquilaL’AquilaItaly

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