Multiple drugs

COVID-19: 4 case reports

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    An event is serious (based on the ICH definition) when the patient outcome is:

    • * death

    • * life-threatening

    • * hospitalisation

    • * disability

    • * congenital anomaly

    • * other medically important event

    “ ”

    In a transversal study of 196 patients (study name: emcovid-19), four patients [ages and sexes not stated] were described, who developed COVID-19 during immunomodulatory treatment with alemtuzumab (1 patient), cladribine (1 patient), interferon-β (1 patient) and ocrelizumab (1 patient) for multiple sclerosis [routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. All patients had positive IgG antibodies for SARS-COV-2. Patients with interferon-β (n=1) and ocrelizumab (n=1) were symptomatic and the patient with ocrelizumab treatment required hospitalisation because of COVID-19.


    1. Hervas-Garcia JV, et al. Seroprevalence of SARS-cOV-2 in multiple sclerosis patients under immunomodulatory treatment in lleida (study emCOVID-19). Multiple Sclerosis Journal 26 (Suppl.): 59 abstr. LB1163, No. 3, Dec 2020. Available from: URL:

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    Multiple drugs. Reactions Weekly 1843, 247 (2021).

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