COVID-19 infection: 2 case reports

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    An event is serious (based on the ICH definition) when the patient outcome is:

    • * death

    • * life-threatening

    • * hospitalisation

    • * disability

    • * congenital anomaly

    • * other medically important event

    “ ”

    In a single-center retrospective study of 170 patients with a history of orthotopic heart transplantation at Henry Ford Hospital in Detroit, Michigan, USA, 2 patients >18 years [sexes not stated; exact ages not stated] were described. The patient's developed COVID-19 infection between 13 March 2020 and 01 May 2020, following immunosuppressive treatment with ciclosporin (one patient) and triple therapy with prednisone, tacrolimus, and mycophenolate-mofetil (one patient) [dosages, routes, durations of treatments to reactions onsets and outcomes not stated].


    1. Al-Darzi W, et al. Heart transplant recipients with confirmed 2019 novel coronavirus infection: The Detroit experience. Clinical Transplantation 34: No. 12, Dec 2020. Available from: URL:

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    Immunosuppressants. Reactions Weekly 1841, 127 (2021).

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