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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series, one man and two women, aged 46-57 years were described who developed hypoglycaemia and hypothermia following treatment with risperidone, quetiapine, zuclopenthixol, haloperidol, lithium, clozapine or olanzapine [not all routes, outcomes and duration of treatments to reaction onsets stated; dosages not stated ].
Patient 1: A 49-year-old man developed hypoglycaemia and hypothermia following treatment with risperidone, olanzapine, quetiapine, zuclopenthixol and haloperidol. The man, who had schizophrenia, generalised arterial disease and type 2 diabetes mellitus was admitted to a psychiatric ward due to psychosis. Subsequently, he started receiving treatment with risperidone. His valproic acid dose was also increased. His concurrent medications included mixed...