Reactions Weekly

, Volume 1695, Issue 1, pp 232–232 | Cite as


Malignant hyperthermia: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A 14-month-old male infant and a 53-year-old man developed malignant hyperthermia following administration of isoflurane [dosages and time to reactions onset not stated].

Case 1: The 14-month-old infant, who was diagnosed with severe pulmonary valve stenosis due to annulus hypoplasia, underwent surgery, during which he received ketamine, fentanyl, pancuronium and midazolam. For the maintenance of anaesthesia, he received midazolam, atracurium, remifentanil and isoflurane inhalation. He underwent cardiopulmonary bypass (CPB), after which he was cooled down to 24°C, and pulmonary valve stenosis was treated using trans-annular patch. At the end of CPB, HR was 130 bpm and BP was 90/45 mmHg. He was started on furosemide and unspecified cardiotonics. Due to low urine output, he was...


  1. Neshati M, et al. Malignant hyperthermia: Report of two cases with a neglected complication in cardiac surgery. Journal of Tehran University Heart Center 12: 175-183, No. 4, Oct 2017. Available from: URL: - IranPubMedPubMedCentralGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

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