Advertisement

Reactions Weekly

, Volume 1694, Issue 1, pp 120–120 | Cite as

Clobetasol/hydroquinone

Cutaneous squamous cell carcinomas: 8 case reports
Case report
  • 25 Downloads
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a descriptive multicenter study, eight women aged 37−63 years were described, who developed cutaneous squamous cell carcinoma (SCC) during treatment with hydroquinone and clobetasol [clobetasol propionate] (n=7) or hydroquinone (n=1); two women died subsequently due to the SCC.

The women were undergoing treatment with topical hydroquinone and clobetasol for the purpose of skin bleaching since 10−35 years [dosage not stated]. They presented for consultation with symptoms of SCC. Histological exams confirmed the presence of SCC which was cauliflower-like (n=4), ulcerated (n=3) and nodular (n=1). The SCC were localised to lichenoid lesions, poikiloderma or exogenous ochronosis on the neck (n=3), face (n=1) or upper back (n=4).

The women underwent surgical resection of the SCC and the outcome was favourable in 6 out of the 8 women. One women (patient 1) developed bone metastasis and died following tumour recurrence. Another woman (patient 8) died due to haemorrhagic shock.

Author comment: "These chronic skinlesions are common but rarely prompt patients to consult a doctor; they are usually associated with long-term use of hydroquinone and clobetasol propionate." "Our aim was to report. . .SCC associated with cosmetic use of skin bleaching products in Senegal."

Reference

  1. Ly F, et al. Cutaneous squamous cell carcinomas (SCC) associated with cosmetic skin whitening: 8 cases reported in Senegal. Annales de Dermatologie et de Venereologie 145: 83-88, No. 2, Feb 2018. Available from: URL: http://doi.org/10.1016/j.annder.2017.10.010 - SenegalCrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Personalised recommendations