Skip to main content
Log in

Pharmacy Benefit Management Companies: Do They Create Value in the US Healthcare System?

  • Current Opinion
  • Published:
PharmacoEconomics Aims and scope Submit manuscript

Abstract

Pharmacy benefit management companies (PBMs) perform functions in the US market-based healthcare system that may be performed by public agencies or quasi-public institutions in other nations. By aggregating lives covered under their many individual contracts with payers, PBMs have formidable negotiating power. They influence pharmaceutical insurance coverage, design the terms of coverage in a plan’s drug benefit, and create competition among providers for inclusion in a plan’s network. PBMs have, through intermediation, the potential to secure lower drug prices and to improve rational prescribing. Whether these potential outcomes are realized within the relevant budget is a function of the healthcare system and the interaction of benefit design and clinical processes—not just individually vetted components. Efficiencies and values achieved in price discounts and cost sharing can be nullified if there is irrational prescribing (over-utilization, under-utilization and mis-utilization), variable patient adherence to medication regimens, ineffective formulary processes, or fraud, waste and abuse. Rising prescription drug costs and the increasing prevalence of ‘high deductible health plans’, which require much greater patient out-of-pocket costs, is creating a crisis for PBM efforts towards an affordable pharmacy benefit. Since PBM rebate and incentive contracts are opaque to the public, whether they add value by restraining higher drug prices or benefit from them is debatable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Adapted from Congress of the United States, Congressional Budget Office [43]

Fig. 2

Figure reproduced with permission of the author

Similar content being viewed by others

References

  1. Dodd P. Content is nothing without context. Financial Times. 2014:1. https://www.ft.com/content/8c2e5f08-77bd-11e3-afc5-00144feabdc0#axzz44COFZubd. Accessed 10 Feb 2017.

  2. The Henry J. Kaiser Family Foundation. 2016 Employer health benefits survey. Washington, DC; 2016. http://kff.org/health-costs/report/2016-employer-health-benefits-survey/. Accessed 10 Feb 2017.

  3. US Department of Health and Human Services. ASPE issue brief: observations on trends in prescription drug spending. 2016. https://aspe.hhs.gov/sites/default/files/pdf/187586/Drugspending.pdf. Accessed 10 Feb 2017.

  4. Martin AB, Hartman M, Benson J, Catlin A, National Health Expenditure Accounts Team. National health spending in 2014: faster growth driven by coverage expansion and prescription drug spending. Health Aff (Millwood). 2016;35(1):150–60.

    Article  Google Scholar 

  5. Blue Cross Blue Shield Blue Health Intelligence. The health of America report. The growth in specialty drug spending from 2013 to 2014. 2016. https://bluehealthintelligence.com/engine/files/The%20Growth%20In%20Specialty%20Drug%20Spending%20From%202013%20To%202014.pdf. Accessed 10 Feb 2017.

  6. McRae J, Vogenberg RF, Beaty SW, Mearns E, Varga S, Pizzi L. A review of US drug costs relevant to medicare, medicaid, and commercial insurers post-affordable care act enactment, 2010–2016. Pharmacoeconomics. 2017;35(2):215–23. doi:10.1007/s40273-016-0458-0.

    Article  PubMed  Google Scholar 

  7. Cox C, Damico A, Claxton G, Levitt L. Examining high prescription drug spending for people with employer sponsored health insurance. Peterson-Kaiser Health System Tracker; 2016. http://www.healthsystemtracker.org/insight/examining-high-prescription-drug-spending-for-people-with-employer-sponsored-health-insurance/. Accessed 10 Feb 2017.

  8. Claxton G, Rae M, Panchal N. Issue brief: consumer assets and patient cost sharing. The Henry J. Kaiser Family Foundation; 2015. http://kff.org/health-costs/issue-brief/consumer-assets-and-patient-cost-sharing/. Accessed 10 Feb 2017.

  9. Hamel L, Norton M, Pollitz K, Levitt L, Claxton G, Brodie M; Kaiser Family Foundation. The burden of Medical Debt: results from the Kaiser Family Foundation/New York Times Medical Bills Survey. Menlo Park: The Henry J. Kaiser Family Foundation; 2016. https://kaiserfamilyfoundation.files.wordpress.com/2016/01/8806-the-burden-of-medical-debt-results-from-the-kaiser-family-foundation-new-york-times-medical-bills-survey.pdf. Accessed 10 Feb 2017.

  10. Brennan T, Shrank W. New expensive treatments for hepatitis C infection. JAMA. 2014;312(6):593–4.

    Article  CAS  PubMed  Google Scholar 

  11. Academy of Managed Care Pharmacy. Managed care terms. PBM-Pharmacy Benefit Management Companies. http://www.amcp.org/ManagedCareTerms/. Accessed 10 Feb 2017.

  12. Navarro RP, Becker AW, Francis W, Tadlock C, Zimmerman A. Pharmacy benefit management companies. In: Navarro RP, editor. Managed care pharmacy. 2nd ed. Sudbury: Jones and Bartlett; 2009.

    Google Scholar 

  13. Japsen B. PBMs quietly gain leverage as drug makers stumble on price hikes. Forbes. 2016. http://www.forbes.com/sites/brucejapsen/2016/08/31/pbms-quietly-gain-leverage-as-drug-makers-stumble-on-price-hikes/#3760e896739b. Accessed 10 Feb 2017.

  14. Express Scripts. https://www.express-scripts.com/index.html. Accessed 10 Feb 2017.

  15. United States Securities and Exchange Commission. Express scripts holding company form 10-K. 31. http://phx.corporate-ir.net/phoenix.zhtml?c=69641&p=irol-SECText&TEXT=aHR0cDovL2FwaS50ZW5rd2l6YXJkLmNvbS9maWxpbmcueG1sP2lwYWdlPTEwNzQ5MTM0JkRTRVE9MCZTRVE9MCZTUURFU0M9U0VDVElPTl9FTlRJUkUmc3Vic2lkPTU3. Accessed 10 Feb 2017.

  16. CVS Caremark. https://www.cvshealth.com/about/our-offerings/cvs-caremark. Accessed 10 Feb 2017.

  17. UnitedHealth Group OPTUMRx. https://www.optumrx.com/RxSolWeb/mvc/home.do. Accessed 10 Feb 2017.

  18. Levinson DR. Medicaid drug price comparisons: average manufacturer price to published prices. Department of Health and Human Services, Office of Inspector General. OEI-05-05-00240. 2005. https://oig.hhs.gov/oei/reports/oei-05-05-00240.pdf. Accessed 10 Feb 2017.

  19. McGlynn E, Asch AM, Adams J, Keesey J, Hicks J, DeCristifaro A, Kerr EA. The quality of health care delivered to adults in the United States. N Engl J Med. 2003;348:2635–45.

    Article  PubMed  Google Scholar 

  20. The Dartmouth Institute for Health Policy and Clinical Practice. Dartmouth Atlas of Healthcare. http://www.dartmouthatlas.org/. Accessed 10 Feb 2017.

  21. Zhang Y, Baicker K, Newhouse JP. Geographic variation in medicare drug spending does not offset variation in other medical spending. N Engl J Med. 2010;363(5):405–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. James B. Quality improvement opportunities in health care—making it easy to do it right. J Manag Care Pharm. 2002;8(5):394–9.

    PubMed  Google Scholar 

  23. Cohen P, Wohletz MC. Managed care pharmacy and pharmacy benefit management. In: Fulda TR, Lyles A, Wertheimer A, editors. Pharmaceutical Public Policy. Boca Raton: CRC Press; 2016.

    Google Scholar 

  24. Blue Cross/Blue Shield of Michigan. Medicare home: how do drug tiers work? http://www.bcbsm.com/medicare/help/understanding-plans/pharmacy-prescription-drugs/tiers.html. Accessed 10 Feb 2017.

  25. Neumann PJ. Evidence-based and value-based formulary guidelines. Health Aff. 2004;23(1):124–34. doi:10.1377/hlthaff.23.1.124.

    Article  Google Scholar 

  26. Choudhry NK, Fischer MA, Smith BF, Brill G, Girdish C, Matlin OS, Brennan TA, Avorn J, Shrank WH. Five features of value-based insurance design plans were associated with higher rates of medication adherence. Health Aff (Millwood). 2014;33(3):493–501. doi:10.1377/hlthaff.2013.0060.

    Article  PubMed  Google Scholar 

  27. Lu CY, Law MR, Soumerai SB, Graves AJ, LeCates RF, Zhang F, Ross-Degnan D, Adams AS. Impact of prior authorization on the use and costs of lipid-lowering medications among Michigan and Indiana dual enrollees in medicaid and medicare: results of a longitudinal, population-based study. Clin Ther. 2011;33(1):135–44. doi:10.1016/j.clinthera.2011.01.012.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Watanabe JH, Kazerooni R, Bounthavong M. Association of copayment with likelihood and level of adherence in new users of statins: a retrospective cohort study. J Manag Care Pharm. 2014;20(1):43–50.

    PubMed  Google Scholar 

  29. Angalakuditi M, Gomes J. Retrospective drug utilization review: impact of pharmacist interventions on physician prescribing. Clinicoecon Outcomes Res. 2011;3:105–8. doi:10.2147/CEOR.S21789.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Vogenberg FR. Pharmacy benefits: plan design and management. International Foundation of Employee Benefit Plans, Inc.; 2011.

  31. Express Scripts. The Lab. http://lab.express-scripts.com/lab/. Accessed 10 Feb 2017.

  32. CVS Health Research Institute. https://www.cvshealth.com/thought-leadership/cvs-health-research-institute. Accessed 10 Feb 2017.

  33. UnitedHealth Group. OPTUM Lab. https://www.optumlabs.com/. Accessed 10 Feb 2017.

  34. Alpert B. Pharmacy-benefit managers under pressure. BARRON’S; 2016. p. 17–19. http://www.barrons.com/articles/pharmacy-benefit-managers-under-fire-1469247082. Accessed 10 Feb 2017.

  35. Pharmacy Benefit Management Institute. 2015–2016 Prescription drug benefit and plan design report. USD/TAK/15/0022. 2015. http://reports.pbmi.com/report.php?id=13. Accessed 10 Feb 2017.

  36. Thomas K. Rival of EpiPen readies for return to the Shelves. NY Times. 2016;27:B7.

    Google Scholar 

  37. US House of Representatives Oversight and Government Reform. [Hearing] Reviewing the rising price of EpiPens. Washington, DC; 2016. https://www.youtube.com/watch?v=W_LVOYp6dOc. Accessed 10 Feb 2017.

  38. Howard DH. Drug Companies’ patient-assistance programs—helping patients or profits? N Engl J Med. 2014;371:97–9.

    Article  CAS  PubMed  Google Scholar 

  39. Department of Health and Human Services, Office of Inspector General Supplemental Special Advisory Bulletin: Independent Charity Patient Assistance Programs, 79 Fed. Reg. 31120 (May 30, 2014) [Notice].

  40. Dafny LS, Ody CJ, Schmitt MA. Undermining value-based purchasing—lessons from the pharmaceutical industry. N Engl J Med. 2016;375(21):2013–5.

    Article  PubMed  Google Scholar 

  41. Patient Protection and Affordable Care Act, 42 U.S.C. § 18001 et seq. (2010).

  42. Fein AJ. Surprise PSAO Consolidation: H.D. Smith and AAP Form fourth-largest pharmacy-PBM negotiating group. 2016. http://www.drugchannels.net/2016/03/surprise-psao-consolidation-hd-smith.html. Accessed 10 Feb 2017.

  43. Congress of the United States, Congressional Budget Office. Issues in designing a prescription drug benefit for Medicare. 2002. https://www.cbo.gov/sites/default/files/107th-congress-2001-2002/reports/10-30-prescriptiondrug.pdf. Accessed 10 Feb 2017.

  44. Centers for Disease Control and Prevention. Viral hepatitis—hepatitis C information. Hepatitis C FAQs for Health Professionals. Last updated 8 January 2016. http://www.cdc.gov/hepatitis/hcv/hcvfaq.htm. Accessed 14 Jan 2016.

  45. Gilead Sciences. US Food and Drug Administration approves Gilead’s Sovaldi™ (Sofosbuvir) for the treatment of chronic hepatitis C [media release]. 2013. http://www.gilead.com/news/press-releases/2013/12/us-food-and-drug-administration-approves-gileads-sovaldi-sofosbuvir-for-the-treatment-of-chronic-hepatitis-c. Accessed 10 Feb 2017.

  46. Pollack A. Harvoni, a hepatitis C drug from Gilead, wins FDA approval. NY Times. 2014. https://www.nytimes.com/2014/10/11/business/harvoni-a-hepatitis-c-drug-from-gilead-wins-fda-approval.html?_r=0. Accessed 10 Feb 2017.

  47. abbvie. AbbVie receives US FDA approval of VIEKIRA PAK™ (ombitasvir/paritaprevir/ritonavir tablets; dasabuvir tablets) for the treatment of chronic genotype 1 hepatitis C [media release]. 2014. https://news.abbvie.com/news/abbvie-receives-us-fda-approval-viekira-pak-ombitasvirparitaprevirritonavir-tablets-dasabuvir-tablets-for-treatment-chronic-genotype-1-hepatitis-c.htm. Accessed 10 Feb 2017.

  48. Walker J. CVS gives preferred status to Gilead’s hepatitis C drugs. Wall Street J. 2015. http://www.wsj.com/articles/cvs-gives-preferred-status-to-gilead-hepatitis-c-drugs-1420478490?cb=logged0.577858249568771. Accessed 10 Feb 2017.

  49. Humer C. Reuters. Express scripts drops Gilead hep C drugs for cheaper AbbVie rival. Reuters Health News. 2014. http://www.reuters.com/article/2014/12/22/us-express-scripts-abbvie-hepatitisc-idUSKBN0K007620141222. Accessed 10 Feb 2017.

  50. Reuters. Merck expects delay for a hepatitis C therapy. NY Times. 2015. http://www.nytimes.com/2015/02/05/business/merck-expects-delay-for-a-hepatitis-c-therapy.html?_r=0. Accessed 10 Feb 2017.

  51. Grant C. The market is missing the upside on Merck. Wall Street J. 2016;26:C14. https://www.wsj.com/articles/market-misses-upside-on-merck-1477409647. Accessed 10 Feb 2017.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alan Lyles.

Ethics declarations

Funding

No sources of funding were used to conduct this study or prepare this manuscript.

Conflict of interest

Alan Lyles has no conflicts of interest that are directly relevant to the content of this article.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lyles, A. Pharmacy Benefit Management Companies: Do They Create Value in the US Healthcare System?. PharmacoEconomics 35, 493–500 (2017). https://doi.org/10.1007/s40273-017-0489-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40273-017-0489-1

Navigation