Edoxaban, a factor Xa inhibitor, is a direct oral anticoagulant (DOAC). DOACs may have a lower incidence of drug-drug interactions (DDIs) than vitamin K antagonists such as warfarin. Nonetheless, DOACs can have clinically relevant pharmacokinetic and pharmacodynamic DDIs. Careful consideration of potential DDIs is needed when prescribing edoxaban, and clinically relevant DDIs may be prevented by avoiding offending combinations, spacing out the timing of the drugs or by halving the dose of edoxaban where indicated.
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The preparation of this review was not supported by any external funding.
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E.S. Kim is a contracted employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. Y.-A. Heo is a salaried employee of Adis International/Springer Nature, is an editor of Drugs & Therapy Perspectives, was not involved in any publishing decision for the manuscript, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
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Kim, E.S., Heo, YA. Consider clinically relevant drug interactions when prescribing edoxaban. Drugs Ther Perspect (2021). https://doi.org/10.1007/s40267-020-00805-y