Chronic functional constipation is symptomatically defined and includes dyssynergic defaecation and normal and slow transit constipation, not secondary to drugs or other conditions. Dietary soluble fibre and laxatives are key treatments, with biofeedback helpful especially in dyssynergic defaecation. Newer pro-secretory and motility-stimulating agents may help those non-responsive to over-the-counter treatments. Although head-to-head and combination therapy trials are lacking, combination therapy in people not responsive to monotherapy is a reasonable approach.
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The preparation of this review was not supported by any external funding.
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C. Fenton and C. Kang are contracted/salaried employees of Adis International Ltd/Springer Nature, and declare no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.
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Fenton, C., Kang, C. Managing functional constipation: the course doesn’t always run smooth. Drugs Ther Perspect (2021). https://doi.org/10.1007/s40267-020-00803-0