Table 1 Adverse drug reactions and interactions: first and selected special-situation case reports recently identified by Reactions Weekly

From: Adverse drug reactions and interactions: first reports and special situations

Drug ADR or outcome Pt gender (age): condition treated References
First reports of ADRs
 Ceftazidine Urinary calculi (serious) M (8 y): NR Gao P, Liu Z, Yang H, et al. Ceftazidime-related urinary calculi in a young boy: a case report. J Int Med Res. 2020;48(4)
 Cimicifuga Superior sagittal and right transverse sinus thrombosis (serious) F (49 y): menopausal symptoms Mittal A, Iliceto A, Yegneswaran B. Herbopathy-induced cephalalgia: remedy gone wrong. J Coll Physicians Surg Pak. 2019;18(3):148–9
 Cinacalcet Cystic parathyroidal adenoma with rapid growth F (56 y): primary hyperparathyroidism Werner C, Lupp A, Mtuka-Pardon G, et al. Case of report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet. BMC Endocr Disord. 2020;20(1):53
 Cissus quadrangularis Thrombocytopenia (serious) M (65 y): backache Kulkami MJ, Bhat AS. Ciccus quadrangularis-induced thrombocytopenia in a renal allograft recipient. Exp Clin Transplant. 2020;18(2):250–1
 Levetiracetam Minimal change disease (serious) M (31 y): generalized tonic-clonic seizures Tarun TN, Tarun T, Malhotra K. First case report of levetiracetam induced MCD: unicorn in the barn [abstract no. 262]. Am J Kidney Dis. 2020;75(4):612
 Phytomenadione Anetoderma F (1 y): neurofibromatosis type 1 Esposito I, Guerriero C, Leoni C, et al. One case of anetoderma post-vitamin K1 injection in a newborn. Int J Dermatol. 2020;59(5):e168–e169
 Tamsulosin Fixed-drug eruption M (54 y); prostatic hyperplasia Montazer F, Jahani Amiri K, Ahmadi A, et al. A first case of fixed drug eruption due to tamsulosin. J Cosmet Dermatol. 2020;19(5):1143–5
In utero drug exposure
 Elvitegravir-containing ARV therapy Fetal death in 2 of 134 pregnancies (serious) 2 F (NR): HIV Badell ML, Sheth AM, Momplaisir F, et al. A multicentre analysis of elvitegravir use during pregnancy on HIV viral suppression and perinatal outcomes. Open Forum Infect Dis. 2019;6(4)
 Paracetamol (high dose) + sertraline Persistent pulmonary hypertension and premature PDA closure in 1 twin at 33-wk GA (serious) F (NR): panic attacks and severe headache Corti CG, Faiola S, Lanna MM, et al. Monochorionic diamniotic twin pregnancy complicated by discordant premature closure of ductus arteriosus. Clin Case Rep. 2020;8(4):685–9
 Valproic acid Spina bifida + other congenital anomalies (pregnancy due to COC failure; serious) F (30): schizoaffective disorder Suri R, Socol DK, Gitlin M. Standard of care: reasonable but not perfect. Am J Psychiatry. 2020;177(3):210–3
ADR associated with a genetic factor
 Progesterone implant Acute intermittent porphyria (serious) F (23 y): contraception Tynan C, O’Dwyer G, Ahern T. Unexplained severe abdominal pain, hyponatemia and visual scotoma: a case report [abstract]. Ir J Med Sci. 2019;188a(Suppl 7):S71
COVID-19 in pts receiving immunosuppressive treatment
 Fingolimod COVID-19 (serious) F (47 y): relapsing-remitting multiple sclerosis Foerch C, Friedauer L, Bauer B, et al. Severe COVD-19 infections in a patient with multiple sclerosis treated with fingolimod. Mult Scler Relat Dis. 2020;14:202180
Medication error, abuse, overdose or under-dose
 Alprazolam Altered mental status + variable fetal heart rate decelerations F (32 y) + fetus (GA 41 wk): overdose and misuse during and post-labour Berman DJ. A case of local anesthetic toxicity that wasn’t: lipid rescue from self-administered benzodiazepine overdose in labor. In J Obstet Anesth. 2020;42:109–11
 Apixaban Femoral vein thrombus (serious) M (43 y): unintentional under-dose in an obese pt (BMI 37.6) O’Riordan S, Wan Mahmood WA. Sub-therapeutic dosing of direct oral anticoagulants in obese patients with deep venous thrombosis [abstract]. Ir J Med Sci. 2019;188(Suppl 7):S38–S39
 Calcium carbamide RPLS + other toxicities (serious) F (48): suicide attempt Penasco Y, Gonzalex-Castro A, Rodriguez-Borregan JC, et al. Posterior reversible leukoencephalopathy after cyanamide overdose. Neurologia. 2020;35(1):67–8
 Citalopram No cardiac event during 24-h post-overdose cardiac telemetry NR: intentional overdose Lee VR, Huang MT, Brambl WJ, et al. Asymptomatic escitalopram and citalopram overdoses: 6-hour observation period? [abstract no. 041]. J Med Toxicol. 2020;16(2):127–8
 Colchicine Multisystem organ failure + other toxicities (serious) F (33 y): intentional overdose Mulkareddy V, Sokach C, Bucklew E, et al. Colchicine toxicity: the fatal masquerade. JACC Case Rep. 2020;2(4):678–80
 Etizolam Somnolence, ataxia + other benzodiazepine-related symptoms 3 children (6–10 y): consumption of unlabelled tablets appearing similar to “Pez” candy Love JS, Thompson JA, Girardi F, et al. Candy coma: a case series of etizolam exposures [abstract no. 044]. J Med Toxicol. 2020;16(2):128
 Hydroxychloroquine Tachycardia, hypotension + other toxicities (serious) F (15 y): intentional overdose Srihari P, Gao HT, Kreshak AA. Massive nonfatal pediatric ingestion of hydroxychloroquine [abstract no. 023] . J Med Toxicol. 2020;16(2):122–3
 Ketamine Bradycardia, diaphoresis, hypotension + other toxicities (serious) M (46 y): error in administration (IV push instead of 0.5–1 h IV infusion) Emerling AD, Fisher J, Walrath B, et al. Rapid ketamine infusion at an analgesic dose resulting in transient hypotension and bradycardia in the emergency department. J Spec Oper Med. 2020;20(1):31–3
  1. An ADR is serious (US FDA MedWatch definition) when the pt outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage.
  2. ADR adverse drug reaction, ARV antiretroviral, BMI body mass index, COC combined oral contraceptive, COVID-19 coronavirus disease 2019, F female, GA gestational age, IV intravenous, M male, mo months, NR not reported, pt patient, RPLS reversible posterior leukoencephalopathy syndrome, PDA patent ductus arteriosus, wk weeks, y years