Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder


Polypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug–drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug.

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The preparation of this review was not supported by any external funding.

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EK searched the literature, prepared the bibliography and wrote the first draft. YAH contributed to the content and revision of the article.

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Correspondence to Young-A. Heo.

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EK and YAH are contracted or salaried employees of Adis International Ltd./Springer Nature and declare no relevant conflicts of interest.

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Kim, E., Heo, Y. Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder. Drugs Ther Perspect (2020).

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