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Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder

  • Drug Reactions and Interactions
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Abstract

Polypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug–drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug.

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Funding

The preparation of this review was not supported by any external funding.

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  1. Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand

    Esther Kim & Young-A. Heo

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  1. Esther Kim
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  2. Young-A. Heo
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EK searched the literature, prepared the bibliography and wrote the first draft. YAH contributed to the content and revision of the article.

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Correspondence to Young-A. Heo.

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EK and YAH are contracted or salaried employees of Adis International Ltd./Springer Nature and declare no relevant conflicts of interest.

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Kim, E., Heo, YA. Consider clinically relevant pharmacokinetic drug interactions when co-prescribing drugs in attention-deficit/hyperactivity disorder. Drugs Ther Perspect 36, 386–388 (2020). https://doi.org/10.1007/s40267-020-00749-3

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  • DOI: https://doi.org/10.1007/s40267-020-00749-3

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