Drugs & Therapy Perspectives

, Volume 34, Issue 11, pp 517–517 | Cite as

First reports of adverse drug reactions

Drug Reactions and Interactions
Table 1 contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks by Reactions Weekly, the Adis drug safety newsletter. Reactions Weekly provides summaries of adverse drug reaction news sourced from journals, scientific meetings, media releases, regulatory agency websites, and bulletins from the National Centers that participate in the WHO International Drug Monitoring Programme.
Table 1

First published reports of adverse drug reactions recently identified by Reactions Weekly

Drug and adverse reaction


Clopidogrel: small bowel ulcer (serious)

Ebi M, Inoue S, Sugiyama T, et al. A small bowel ulcer due to clopidogrel with cytomegalovirus enteritis diagnosed by capsule and double-balloon endoscopy. Case Rep Gastroenterol 2018;12(2):303–10.

Cyclizine: Nicolau syndrome (serious)

Tabor D, Bertram CG, Williams AJK, et al. Nicolau syndrome (embolia cutis medicamentosa): a rare and poorly recognized iatrogenic cause of cutaneous thrombotic vasculopathy. Am J Dermatopathol. 2018;40(3):212–5.

Ibrutinib: Sweet syndrome (serious)

El Halabi L, Cherif-Rebai K, Michot JM, et al. Ibrutinib-induced neutrophilic dermatosis. Am J Dermatopathol. 2018;40(3):198–200.

Triptorelin: transient hyperthyroidism (serious)

Miao J, Yan Q, Wang L, et al. Three cases of transient hyperthyroidism after triptorelin treatment-case report and literature review. Gynecol Endocrinol. 2018;34(9):734–5.

An event is serious (US FDA MedWatch definition) when the patient outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage

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© Springer Nature Switzerland AG 2018

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