Abstract
Dolutegravir/rilpivirine (Juluca®) is the first two-drug single-tablet regimen (STR) to be approved for the treatment of HIV-1 infection in adults. The fixed-dose STR combines the integrase strand transfer inhibitor dolutegravir with the non-nucleoside reverse transcriptase inhibitor rilpivirine. In two phase III non-inferiority trials (SWORD-1 and SWORD-2) in treatment-experienced patients already virologically suppressed on their current antiretroviral (ART) regimen, switching to once-daily dolutegravir plus rilpivirine maintained virological suppression over 48 weeks. Switching to a two-drug regimen of dolutegravir plus rilpivirine was also associated with high rates of virological suppression in real-world observational studies. Switching to once-daily dolutegravir plus rilpivirine was generally well tolerated and associated with more favourable renal and bone parameters than remaining on the current ART regimen. Longer-term, dolutegravir plus rilpivirine demonstrated durable maintenance of virological suppression and remained generally well tolerated for up to 100 weeks. Thus, dolutegravir/rilpivirine provides a convenient alternative treatment option for some adults with HIV-1 infection and no history of virological failure who are already virologically suppressed on (and wish to switch from) their current ART regimen.
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Acknowledgements
During the peer review process, the manufacturer of dolutegravir/rilpivirine was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.
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The preparation of this review was not supported by any external funding.
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Hannah Blair is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.
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The manuscript was reviewed by: D. M. Burger, Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands; J. M. Llibre, HIV Unit, Lluita Contra La SIDA Foundation, Barcelona, Spain; M. Nelson, Chelsea and Westminster Hospital, London, United Kingdom.
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Blair, H.A. Dolutegravir/Rilpivirine: A Review in HIV-1 Infection. Drugs 78, 1741–1750 (2018). https://doi.org/10.1007/s40265-018-1005-4
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DOI: https://doi.org/10.1007/s40265-018-1005-4