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Drug Safety

, Volume 41, Issue 5, pp 539–540 | Cite as

Comment on: “Safety of Human Papillomavirus Vaccines: An Updated Review”

  • Manuel Martínez-Lavín
Letter to the Editor

To the Editor,

In their updated literature review of HPV vaccine safety, Phillips et al. focused on the new 9-valent HPV vaccine, and on adverse events of special interest. Their conclusion was that “The risk–benefit profile for HPV vaccines remains highly favourable” [1]. Our recent analysis of the same scientific literature reached an opposite conclusion [2]. Our divergent opinion is based on the following reasoning.

The Phillips et al. review found no increased risk of death in bivalent HPV vaccine clinical trials [1]. Our analysis did [2]. The VIVIANE study compared 2871 women receiving aluminum placebo, with 2881 women injected with the bivalent HPV vaccine. The bivalent HPV vaccine group had more deaths on follow-up (14 vs 3, p = 0.012 by Fisher’s exact test). None of the deaths were believed to be related to vaccination [3].

Phillips et al. state: “Data from clinical trials reported a similar safety profile for the 9-valent HPV vaccine as for 4-valent HPV vaccine” [1]. Our...

Notes

Compliance with Ethical Standards

Funding

No sources of funding were used to assist in the preparation of this letter.

Conflicts of interest

Manuel Martínez-Lavín has no conflicts of interest that are directly relevant to the content of this letter.

References

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    Phillips A, Patel C, Pillsbury A, Brotherton J, Macartney K. Safety of human papillomavirus vaccines: an updated review. Drug Saf. 2017;41(4).  https://doi.org/10.1007/s40264-017-0625-z.
  2. 2.
    Martínez-Lavín M, Amezcua-Guerra L. Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series. Clin Rheumatol. 2017;36(10):2169–78 (Erratum in: Clin Rheumatol).CrossRefPubMedGoogle Scholar
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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Rheumatology DepartmentNational Institute of CardiologyMexico CityMexico

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