Skip to main content

Table 4 Ten vaccine–event pairs for which model 3 gave the highest probability of being an adverse reaction following immunization

From: Use of Logistic Regression to Combine Two Causality Criteria for Signal Detection in Vaccine Spontaneous Report Data

Vaccine: event Listed? PRRE PRRLL KSBE KSBV Prob model 1 (%) Prob model 2 (%) Prob model 3 (%)
Engerix™: Myalgia Yes ]0.8, 1.2] ]0.8, 1.2] [Min, Q1[ 0 36 84 93
Infanrix™: Pyrexia Yes [0, 0.8] [0, 0.8] [Min, Q1[ 0 9 84 86
Rotarix™: Diarrhoea Yes ]10, 100] ]10, 100] [Min, Q1[ [Min, Q1[ 16 86 84
Engerix™: Pruritus Yes ]0.8, 1.2] ]0.8, 1.2] 0 [Min, Q1[ 36 69 83
Engerix™: Vomiting Yes ]0.8, 1.2] ]0.8, 1.2] [Min, Q1[ [Q1, Median[ 36 70 83
Engerix™: Abdominal pain Yes ]1.2, 2] ]0.8, 1.2] [Q1, Median[ [Min, Q1[ 24 74 82
Twinrix™: Fatigue Yes ]0.8, 1.2] ]0.8, 1.2] >0.01 [Min, Q1[ 36 67 82
Engerix™: Arthralgia Yes ]0.8, 1.2] ]0.8, 1.2] 0 0 36 65 82
Havrix™: Headache Yes ]0.8, 1.2] [0, 0.8] [Median, Q3[ 0 12 77 81
Cervarix™: Pyrexia Yes ]0.8, 1.2] [0, 0.8] [Median, Q3[ 0 12 77 81
  1. BE between events, BV between vaccines, E estimate, KS Kolmogorov–Smirnov, LL lower limit, Prob estimated probability, PRR proportional reporting ratio