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Fig. 4 | Drug Safety

Fig. 4

From: Improved Statistical Signal Detection in Pharmacovigilance by Combining Multiple Strength-of-Evidence Aspects in vigiRank

Fig. 4

a Receiver operating characteristic curves for our new screening algorithm, vigiRank, standard disproportionality analysis (IC025), and raw numbers of reports, relative to the benchmark based on historic European Medicines Agency safety signals. The difference between vigiRank and IC025 is statistically significant (p < 0.001 using DeLong’s test [36]). The circle corresponds to the standard threshold for IC025, 0, and the 45° line corresponds to random guessing. b Area under the curve (AUC) values for the three methods from the evaluation on all data as well as from the individual iterations of the cross-validation. The error bars indicate 95 % confidence intervals. The mean values over the cross-validation folds are 0.775, 0.736, and 0.707 for vigiRank, IC025, and raw numbers of reports, respectively. IC information component, IC 025 is the lower limit of the two-sided 95 % credibility interval for the IC disproportionality measure

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