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Fig. 3 | Drug Safety

Fig. 3

From: Improved Statistical Signal Detection in Pharmacovigilance by Combining Multiple Strength-of-Evidence Aspects in vigiRank

Fig. 3

Outline of how vigiRank applies to a set of eight reports on a fictional drugadverse drug reaction pair. The first part shows a conceptual summary of each report. As an example, the top left report is a report from Switzerland that includes a case narrative, attains a vigiGrade completeness score of 1.0, and was received in 1995. The second part shows the raw data for each of the predictors (three informative reports, four recent reports, disproportionality = TRUE, three reports with case narratives, and four countries of origin with positive Information Component). The third part displays the corresponding transformed values that are multiplied with their corresponding estimated coefficients. The fourth part sums the independent contributions from all variables with the intercept (−3.45) to produce the overall score of −1.45 on logit scale, which corresponds to a 19 % probability. Either the score or the probability could be used for ranking purposes. Note: here the year 2014 is used as a reference point to determine whether or not a report is recent

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