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Fig. 2 | Drug Safety

Fig. 2

From: Improved Statistical Signal Detection in Pharmacovigilance by Combining Multiple Strength-of-Evidence Aspects in vigiRank

Fig. 2

a Estimated coefficients by lasso logistic regression for all considered variables. The top five variables with non-zero coefficients define our new screening algorithm, vigiRank. The model intercept was −3.45. b All non-zero coefficients estimated by lasso logistic regression for any variable, either based on all data (as in a) or when excluding a fold during fivefold cross-validation. Positive and negative controls were randomly assigned to one of five folds, so that each fold contains 20 % of the entire reference dataset

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