Dear Reader,

As we reach the final issue of Clinical Drug Investigation for 2018, we wish to reflect on another successful year’s achievements, and to thank all those who have contributed their time and effort to guarantee the high quality of our content.


2018 was a successful year for Clinical Drug Investigation. Over 115 articles have been published; the most popular of these, in terms of downloads from SpringerLink, have been:


Raffa, R.B., Pawasauskas, J., Pergolizzi, J.V., et al. Pharmacokinetics of oral and intravenous paracetamol (acetaminophen) when co-administered with intravenous morphine in healthy adult subjects. Clin Drug Investig (2018) 38:259. https://doi.org/10.1007/s40261-017-0610-4

Nunes, S.L., Forsberg, S., Blomqvist, H., et al. Effect of sedation regimen on weaning from mechanical ventilation in the intensive care unit. Clin Drug Investig (2018) 38:535. https://doi.org/10.1007/s40261-018-0636-2

Goldsmith, D., Dellanna, F., Schiestl, M., et al. Epoetin biosimilars in the treatment of renal anemia: what have we learned from a decade of European experience? Clin Drug Investig (2018) 38:481. https://doi.org/10.1007/s40261-018-0637-1

Vieta, E., Montes, J.M. A Review of asenapine in the treatment of bipolar disorder. Clin Drug Investig (2018) 38:87. https://doi.org/10.1007/s40261-017-0592-2

Hu, Y., Chen, Z., Gong, Y., et al. A review of switching biologic agents in the treatment of moderate-to-severe plaque psoriasis. Clin Drug Investig (2018) 38:191. https://doi.org/10.1007/s40261-017-0603-3


The quality of articles published in the journal is also reflected in its most recent impact factor (2017 impact factor 1.918).


Other journals in the Adis Premier Journals Portfolio (http://www.springer.com/gp/adis) continue to prosper with substantial increases in usage year on year. In addition, this year has seen Applied Health Economics and Health Policy receive its first impact factor.


We thank the authors who have contributed articles to Clinical Drug Investigation over the course of 2018. The skill and dedication of all authors are critical to the continued publication of the journal. The quality of published articles is also testament to the significant efforts of the peer reviewers, whose commitment ensures that the journal’s content is held to the highest possible standard. We would like to thank the following individuals who acted as reviewers for Clinical Drug Investigation in the last 12 months:


Jad Abdallah, Lebanon

Khaled S. Abdelkawy, Egypt

Adedayo B. Adedoyin, USA

Steven M. Albert, USA

Karel Allegaert, Belgium

Ali Amidi, Denmark

Dominick J. Angiolillo, USA

Ariane G. Araujo, Brazil

Kristopher Attwood, USA

Luis Bahamondes, Brazil

Julio Bassas-Vila, Spain

Burcu Belen, Turkey

Wilma F. Bergfeld, USA

Carmen Bernal-Bellido, Spain

Jean-Baptiste Beuscart, France

Antonio Boix-Montanes, Spain

Claudio Borghi, Italy

Natale D. Brunetti, Italy

Christian Cadeddu, Italy

Amedeo F. Capetti, Italy

Jose M. Carrascosa, Spain

Juana Carretero Gómez, Spain

Dario Cattaneo, Italy

Claudio Cerchione, Italy

Amy Chan, UK

Hardik Chandasana, USA

Jongwha Chang, USA

Jaime E. Charris, Bolivarian Republic of Venezuela

Xuwang Chen, China

Sang-Heon Cho, Republic of Korea

Imti Choonara, UK

Ananda Chowdhury, USA

Theodore J. Cicero, USA

Fabrizio D’Ascenzo, Italy

Ranjeet P. Dash, USA

Michelino de Laurentiis, Italy

Jasper Dingemanse, Switzerland

Zoubir Djerada, France

Athanassios Douzenis, Greece

Gihan Elsisi, Egypt

Laszlo Endrenyi, Canada

Abiy H. Eyakem, USA

Gianluca Fabiano, UK

Giampiero Favato, UK

Javier Fernandez-Ruiz, Spain

Michael A. Fridrik, Austria

Hitomi Fujii, Japan

Stefan Gebhardt, Germany

Armando Genazzani, Italy

Panagiotis I. Georgianos, Greece

Rafael Gorodischer, Israel

George Gourzoulidis, Greece

Ashish Goyal, USA

Tomasz Grabowski, Poland

Jordi Guitart, Spain

Yong-Long Han, China

Sam Harirforoosh, USA

Johannes Hennings, Germany

Swapnil Hiremath, Canada

Hasniza Zaman Huri, Malaysia

Noriyoshi Iriyama, Japan

Jorge Jacinto, Portugal

Youxin Ji, China

Sun-Young Jung, Republic of Korea

Reena V. Kartha, USA

Jumpei Kashima, Japan

Takumi Kawaguchi, Japan

Umut Kefeli, Turkey

Puja Khanna, USA

Charles Khouri, France

Takashi Kijima, Japan

Guido Knapp, Germany

Tsunenori Kondo, Japan

Shih-Wei Lai, Taiwan, Republic of China

Yu Jeung Lee, Republic of Korea

Yue-Chune Lee, Taiwan, Republic of China

Thankappan Lekha, India

Minghui Li, USA

Xuejun Li, China

Hua Ling, USA

Patricia Lowe, Australia

Samuel J. Mann, USA

Lyndon Mansfield, USA

Noha O. Mansour, Egypt

Dan Martinusen, Canada

T. Joseph Mattingly II, USA

Massimo C. Mauri, Italy

Russell K. McAllister, USA

Natalie Medlicott, New Zealand

Kevin Meesters, Belgium

Jae Sun Min, USA

Roberto Minutolo, Italy

Tsuyoshi Mitsuishi, Japan

Jeremy J. Moeller, USA

Caroline F. A. Moreira-Nunes, Brazil

Ion G. Motofei, Romania

Stefanie H. Müller, Germany

Nisha Nanaware-Kharade, USA

Beatrice Nardone, USA

Timothy Nguyen, USA

Hoa Q. Nguyen, USA

Jing Niu, USA

Silpa Nuthalapati, USA

Takamasa Ohki, Japan

Shunsuke Ono, Japan

Yukinori Ozaki, Japan

Alberto Palazzuoli, Italy

Harish S. Parihar, USA

Napa Parinyanitikul, Thailand

Inwhee Park, Republic of Korea

Francesca Pasi, Italy

John D. Pauling, UK

Lev Pavlovsky, Israel

Alyssa M. Peckham, USA

Fuxing Pei, China

John F. Peppin, USA

Francesca Poggio, Belgium

Elisabetta Poluzzi, Italy

Koen B. Pouwels, The Netherlands

Emőke Rácz, The Netherlands

Mark H. Rapaport, USA

Umberto Restelli, Italy

Oliver Riedel, Germany

Mothaffar F. Rimawi, USA

Donna R. Rivera, USA

Matteo Ruggeri, Italy

Jianzhong Rui, China

Akinori Sairaku, Japan

Yoshifumi Saisho, Japan

Luis Sargento, Portugal

Filippo M. Sarullo, Italy

Andrea Savarino, Italy

Hans-Joachim Schmoll, Germany

Angel Sesar, Spain

Abdul Naveed Shaik, USA

De-Wei Shang, China

Satish Sharan, USA

Joseph J. Shatzel, USA

Lawrence D. Sher, USA

Jian Shi, USA

Lizheng Shi, USA

Kwang-Hee Shin, Republic of Korea

Lee P. Shulman, USA

David M. Simpson, USA

Mark W. Sonderup, South Africa

Konstantinos Stavropoulos, Greece

Naeti Suksomboon, Thailand

Muzeeb Syed, USA

Yoshinori Takeuchi, Japan

Dandan Tian, USA

Rodrigo M. Tonella, Brazil

Lucio Tremolizzo, Italy

Kimihiko Urano, Japan

Pietro Vajro, Italy

John N. van den Anker, USA

Joris J. Van den Bossche, Belgium

Jing Wang, USA

Li-Quan Wang, China

Zhiyu Wang, China

Chana Weinstock, USA

Yu-Wen Wen, Taiwan, Republic of China

Karn Wijarnpreecha, USA

Kyle J. Wilby, Qatar

William W.L. Wong, Canada

Jing Wu, China

Hong-Guang Xie, China

Satoru Yamada, Japan

Hirosuke Yamaji, Japan

Li Yang, China

Umit Yasar, Turkey

Chao Zhang, China

Qian Zhao, China

Ming Zhong, China

Focke Ziemssen, Germany


In addition, we would like to thank the members of the journal’s Honorary Editorial Board, who have acted as peer reviewers and authors, and have provided guidance on journal content, policy and processes:


E. Battegay, Basel, Switzerland

E. Beghi, Milan, Italy

L. Bertilsson, Stockholm, Sweden

H. Bhally, Auckland, New Zealand

B. Brüggenjürgen, Berlin, Germany

S.G. Carruthers, Lisburn, Northern Ireland

A. Chiricozzi, Pisa, Italy

E. Christophers, Kiel, Germany

K. Detyniecki, New Haven, CT, USA

M. J. Eadie, Brisbane, QLD, Australia

D. E. Furst, Los Angeles,CA, USA

H. Giamarellou, Athens, Greece

S. Goutelle, Lyon, France

Y. Hamamoto, Osaka, Japan

P. D. Home, Newcastle upon Tyne, England

E. Jouanjus, Toulouse, France

N. M. Kaplan, Dallas, TX, USA

T. K. L Kiang, Edmonton, ALB, Canada

G. L. Kearns, Kansas City, MO,USA

F. K. Knop, Hellerup, Denmark

J. Lötsch, Frankfurt, Germany

G. Maconi, Milan, Italy

H. I. Maibach, San Francisco, CA, USA

A. Marcellusi, University of Rome, Rome, Italy

T. O. Morgan, Melbourne, Vic., Australia

G. L. Morris III, Milwaukee, WI, USA

F. M. Muggia, New York, NY, USA

M. Narukawa, Tokyo, Japan

N. Pérez Álvarez, Barcelona, Spain

E. Perucca, Pavia, Italy

E. Raschi, Bologna, Italy

G. Sani, Rome, Italy

S. K. Sarin, New Delhi, India

S. C. Schachter, Boston, MA, USA

M. Schmitt-Egenolf, Umeå, Sweden

T. L. Skaer, Spokane, WA, USA

C. Staatz, Woolloongabba, QLD, Australia

A. M. Taburet, Le Kremlin Bicêtre, France

G. Trifirò, Messina, Italy

P. Tugwell, Ottawa, ONT, Canada

D. Veritti, Udine, Italy

V. T. Wong, Hong Kong, China

D. Wright, Dunedin, New Zealand

B. Wu, Shanghai, China

H. Zhao, Beijing,China


We do hope that you have found the articles published throughout the year in Clinical Drug Investigation to be interesting and informative. The editorial schedule for 2019 is well under way, and we are looking forward to bringing you many high-quality and authoritative articles over the coming year.


With best wishes,


Jasbir Singh