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American Journal of Clinical Dermatology

, Volume 19, Issue 4, pp 609–615 | Cite as

Clinical and Therapeutic Aspects of Linear Psoriasis: A Study of 30 Cases

  • Matthieu Say
  • Franck Boralévi
  • Cédric Lenormand
  • Anne-Claire Bursztejn
  • Eric Estève
  • Alice Phan
  • Emmanuelle Bourrat
  • Jean-Philippe Lacour
  • Marie-Aleth Richard
  • Aurélie Acher
  • Denis Jullien
  • Nathalie Beneton
  • Vincent Descamps
  • Christine Bodemer
  • Marion Lagaude
  • Christine Chiaverini
  • Emmanuel Mahé
  • For the Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie, and the Groupe de Recherche de la Société Française de Dermatologie Pédiatrique
Original Research Article

Abstract

Background

Psoriasis affects 2–4% of the population, with the most common clinical type being plaque psoriasis. The linear form of psoriasis is very rare. The literature on linear psoriasis (LP) consists of only case reports, and data are few.

Objective

This study aimed to better understand LP in a large-scale study.

Patients and Methods

We retrospectively retrieved the medical records from 14 French medical centers of patients newly diagnosed clinically with LP, with or without the support of histology, between 1 February and 31 July 2015. For each case, we assessed the clinical features, treatments and treatment efficacy.

Results

In total, 30 cases of LP (mean age 26.8 years, 13 males) were reported. Mean age at onset of LP was 20.0 years, with 18 developing LP in childhood. Ten patients had a family history of psoriasis, and two had psoriatic arthritis. A total of 19 cases were linear at onset, with concomitant classical psoriasis; these were termed “superimposed” LP. The remaining 11 cases were not associated with classical psoriasis and were termed “isolated” LP. In four of the superimposed cases, LP developed when the patient was receiving systemic treatment: methotrexate (n = 2), etanercept (n = 1) or infliximab (n = 1). Topical steroids were effective in 76% of cases in which they were used, and systemic treatment was effective in < 66%. Treatments were less effective in LP than in classical psoriasis.

Discussion

We identified a wide range of LP, with two profiles: isolated LP and superimposed LP. Topical treatment usually evoked clinical response, with relative resistance to systemic therapy. Methotrexate and anti-tumor necrosis factor (TNF)-α therapies can possibly unmask LP.

Notes

Compliance with Ethical Standards

Funding

No sources of funding were used to conduct this study or prepare this manuscript.

Conflicts of interest

MS, FB, CL, A-CB, EE, AP, EB, J-PL, M-AR, AA, DJ, NB, VD, CB, ML, CC and EM have no conflicts of interest that are directly relevant to the content of this study.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Matthieu Say
    • 1
  • Franck Boralévi
    • 2
  • Cédric Lenormand
    • 3
  • Anne-Claire Bursztejn
    • 4
  • Eric Estève
    • 5
  • Alice Phan
    • 6
  • Emmanuelle Bourrat
    • 7
  • Jean-Philippe Lacour
    • 8
  • Marie-Aleth Richard
    • 9
  • Aurélie Acher
    • 10
  • Denis Jullien
    • 11
  • Nathalie Beneton
    • 12
  • Vincent Descamps
    • 13
  • Christine Bodemer
    • 14
  • Marion Lagaude
    • 10
  • Christine Chiaverini
    • 8
  • Emmanuel Mahé
    • 1
  • For the Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie, and the Groupe de Recherche de la Société Française de Dermatologie Pédiatrique
  1. 1.Service de DermatologieHôpital Victor DupouyArgenteuilFrance
  2. 2.Unité de Dermatologie PédiatriqueHôpital Pellegrin-EnfantsBordeauxFrance
  3. 3.Service de DermatologieHôpitaux Universitaires de StrasbourgStrasbourgFrance
  4. 4.Service de DermatologieHôpital BraboisVandœuvre Les NancyFrance
  5. 5.Service de DermatologieCentre Hospitalier Régional d’OrléansOrléansFrance
  6. 6.Service de PédiatrieHôpital Femme-Mère-EnfantBronFrance
  7. 7.Service de Pédiatrie GénéraleHôpital Robert Debré, Assistance Publique-Hôpitaux de ParisParisFrance
  8. 8.Service de Dermatologie, Hôpital Archet 2ESPIC CHU-LenvalNiceFrance
  9. 9.Service de Dermatologie, UMR 911 Inserm CRO2, Hôpital Timone, Assistance publique des Hôpitaux de Marseille, Centre de recherche en oncologie biologique et onco-pharmacologieUniversité Aix-MarseilleMarseilleFrance
  10. 10.Service de DermatologieCentre Hospitalier Universitaire de Caen, Université de Caen Basse-Normandie, UFR de MédecineCaenFrance
  11. 11.Service de DermatologieHôpital Edouard Herriot, University Claude Bernard Lyon-1LyonFrance
  12. 12.Service de DermatologieCentre Hospitalier du MansLe MansFrance
  13. 13.Service de Dermatologie, Centre Hospitalier Universitaire Bichat-Claude Bernard, Assitance Publique-Hôpitaux de ParisParis 7 Diderot UniversityParisFrance
  14. 14.Service de DermatologieHôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris-Descartes Sorbonne Paris CitéParisFrance

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