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Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors for Cardiovascular Disease Prevention

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Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Because of these associated risks, managing diabetes and CVD, including heart failure (HF), has become a joint effort to reduce the risk of adverse outcomes. Although many patients with T2DM are receiving preventive therapies for CVD, their residual risk remains high for atherosclerotic CVD (ASCVD). Recent data regarding the use of antidiabetic medications to prevent negative cardiovascular outcomes has revealed a positive association with reduced major adverse cardiovascular events (MACE). One class of medications, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, are at the forefront of the cardiovascular outcomes prevention discussion. The clinical data presented in this review indicate the potential cardiovascular benefits of SGLT-2 inhibitors in patients with CVD and its potential value as a treatment option in preventing CVD in various patient populations.

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Authors and Affiliations

  1. East Coast Institute for Research, 3550 University Blvd. South, Suite 101, Jacksonville, FL, 32216, USA

    Jessica Reid, Khyatiben Rana, Stephanie Niman, Rushab R. Choksi & Rebecca F. Goldfaden

  2. University of Florida College of Pharmacy, Jacksonville, FL, USA

    Jessica Reid

  3. Northeast Florida Endocrine and Diabetes Associates, Jacksonville, FL, USA

    Mae Sheikh-Ali

  4. Baker-Gilmour Cardiovascular Institute, Jacksonville, FL, USA

    Todd Lewis

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  1. Jessica Reid
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Correspondence to Rebecca F. Goldfaden.

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Jessica Reid, Khyatiben Rana, Stephanie Niman, Mae Sheikh-Ali, Todd Lewis, Rushab R. Choksi, and Rebecca F. Goldfaden have no potential conflicts of interest that might be relevant to the contents of this manuscript.

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Reid, J., Rana, K., Niman, S. et al. Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors for Cardiovascular Disease Prevention. Am J Cardiovasc Drugs 20, 419–429 (2020). https://doi.org/10.1007/s40256-020-00397-y

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