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CuCl2/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides

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Abstract

A general and efficient coupling of aryl bromides with diethyl malonate is presented. The reaction provided the α-arylated diethyl malonates in moderate to good yields with a low loading of CuCl2(5%, molar fraction) and 8-hydroxyquinoline(5%, molar fraction). This method has good compatibility for a wide range of aryl bromides.

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun, 113001, P. R. China

    Jiuquan Yang & Yupeng He

  2. Jilin Province Key Lab of Green Chemistry and Process, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

    Jiuquan Yang, Guojie Wu & Fushe Han

Authors
  1. Jiuquan Yang
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  2. Guojie Wu
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  3. Yupeng He
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  4. Fushe Han
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Corresponding authors

Correspondence to Guojie Wu or Yupeng He.

Additional information

Supported by the National Natural Science Foundation of China(Nos.21572215, 21602215).

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Yang, J., Wu, G., He, Y. et al. CuCl2/8-Hydroxyquinoline-catalyzed α-Arylation of Diethyl Malonate with Aryl Bromides. Chem. Res. Chin. Univ. 34, 727–731 (2018). https://doi.org/10.1007/s40242-018-8137-7

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  • DOI: https://doi.org/10.1007/s40242-018-8137-7

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