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Light-stimulus Dual-drug Responsive Nanoparticles for Photoactivated Therapy Using Mesoporous Silica Nanospheres

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Abstract

Photoactivated therapy is an exciting new method of cancer treatment. A new light-stimulus dual-drug responsive nanoparticles based on mesoporous silica nanoparticles(MSN) were developed to control cellular anticancer drug release. The prepared Curcumin(Cur)-loaded nanoparticles MSN-Pt-PEG@Cur[PEG=poly(ethylene glycol)] could be activated by photostimulation to generate reactive oxygen species(ROS) from Cur and Pt(II) from Pt(IV), respectively. Compared with free anti-cancer drugs’ chemotherapy and single photoactivated therapy, the prepared MSN-Pt-PEG@Cur displayed increased cytotoxicity. Therefore, the strategy of light-stimulus dual-drug responsive nanoparticles is a promising approach to photoactivated therapy.

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Authors and Affiliations

  1. College of Chemistry, Jilin University, Changchun, 130021, P. R. China

    Peng Wu & Jizhen Li

  2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China

    Dongfang Zhou & Yubin Huang

Authors
  1. Peng Wu
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  2. Dongfang Zhou
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  3. Yubin Huang
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  4. Jizhen Li
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Corresponding author

Correspondence to Jizhen Li.

Additional information

Supported by the National Natural Science Foundation of China(No.51573069) and the Project of the Department of Science & Technology of Jilin Province, China(No.20170414052GH).

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Wu, P., Zhou, D., Huang, Y. et al. Light-stimulus Dual-drug Responsive Nanoparticles for Photoactivated Therapy Using Mesoporous Silica Nanospheres. Chem. Res. Chin. Univ. 34, 676–683 (2018). https://doi.org/10.1007/s40242-018-8077-2

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  • DOI: https://doi.org/10.1007/s40242-018-8077-2

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