Abstract
A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of 1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibac-terial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S.au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.
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Supported by the Program for Innovative Research Team of the Ministry of Education of China, the Program for Liaoning Innovative Research Team in University, China(No.IRT1073) and the Basic Program of Liaoning Provincial Department of Education, China(No.2017LZD06).
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Xu, B., Ding, X., Wu, Y. et al. Synthesis and antibacterial activity of oxazolidinone derivatives containing nitro heteroaromatic moiety. Chem. Res. Chin. Univ. 34, 51–56 (2018). https://doi.org/10.1007/s40242-018-7302-3
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DOI: https://doi.org/10.1007/s40242-018-7302-3