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Cardiovascular diseases risk prediction in patients with diabetes: Posthoc analysis from a matched case-control study in Bangladesh

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Abstract

Purpose

This study aimed to investigate the estimated 10-year predicted risk of developing cardiovascular diseases (CVD) among participants with and without diabetes in Bangladesh.

Methods

We performed posthoc analysis from a matched case-control study conducted among 1262 participants. A total of 631 participants with diabetes (case) were recruited from a tertiary hospital, and 631 age, sex and residence matched participants (control) were recruited from the community in Dhaka, Bangladesh. Socioeconomic anthropometric, clinical and CVD risk factor data were collected from the participants. The 10-year estimated CVD risk was calculated using the Framingham Risk Score, which has reasonable validity in South Asians.

Results

The mean (SD) age of the participants were 51 (10) years. Total 52.3% of cases and 17.2% of controls were at high risk for CVD. The 10-year risk of CVD increased by age and was higher among males in both groups. Among the control group, high CVD risk was more prevalent among higher education and income groups. More than 85% of the tobacco smokers and 70% of chewing tobacco users in the case group were at high risk of CVD. Prevalence of high CVD risk among non-smokers cases was 8.6%. About 35% of hypertensive participants in the control group were at high risk of CVD.

Conclusion

Bangladeshi patients with diabetes showed a significant burden of CVD risk at a relatively younger age. Strategies for reducing tobacco use and improving BP control in people with diabetes is needed for lowering future CVD risks.

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Funding

This research protocol was funded by icddr,b’s core Sida Grant Number PR-13062. icddr,b also gratefully acknowledges the following donors which provide unrestricted support: Australian Agency for International Development (AusAID), Government of the People’s Republic of Bangladesh, Canadian International Development Agency (CIDA), Swedish International Development Cooperation Agency (Sida), and the Department for International Development, UK (DFID).

Author information

Authors and Affiliations

  1. Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia

    Sheikh Mohammed Shariful Islam & Riaz Uddin

  2. Cardiovascular Division, The George Institute for Global Health, Newtown, Australia

    Sheikh Mohammed Shariful Islam

  3. Sydney Medical School, University of Sydney, Camperdown, Australia

    Sheikh Mohammed Shariful Islam

  4. Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA

    Shyfuddin Ahmed

  5. International Centre for Diarrhoeal Diseases, Bangladesh, Dhaka, Bangladesh

    Shyfuddin Ahmed

  6. Marshfield Clinic Health System, Rice Lake, WI, USA

    Muhammad U. Siddiqui

  7. George Washington University, Washington, D.C., USA

    Muhammad U. Siddiqui

  8. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahsa Malekahmadi

  9. Nutrition Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahsa Malekahmadi

  10. Department of Computer Science and Engineering, United International University, Dhaka, Bangladesh

    Abdullah Al Mamun

  11. Institute for Intelligent Systems Research and Innovation, Deakin University, Geelong, VIC, Australia

    Roohallah Alizadehsani, Abbas Khosravi & Saeid Nahavandi

Authors
  1. Sheikh Mohammed Shariful Islam
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  2. Shyfuddin Ahmed
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  4. Muhammad U. Siddiqui
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  6. Abdullah Al Mamun
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  7. Roohallah Alizadehsani
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  8. Abbas Khosravi
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  9. Saeid Nahavandi
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Contributions

All authors substantially contributed to conception and design, collection of data, or analysis and interpretation of data and critical revision of intellectual content. SMSI and SA conceived and designed the study. SA performed the statistical analysis. SMSI, SA were involved in interpretation and revision of all drafts of the manuscript. RU and MUS, MM, AAM, AK and SN contributed to the critical revising of interpretation and finalizing the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sheikh Mohammed Shariful Islam.

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Islam, S.M.S., Ahmed, S., Uddin, R. et al. Cardiovascular diseases risk prediction in patients with diabetes: Posthoc analysis from a matched case-control study in Bangladesh. J Diabetes Metab Disord 20, 417–425 (2021). https://doi.org/10.1007/s40200-021-00761-y

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  • DOI: https://doi.org/10.1007/s40200-021-00761-y

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