Meta-inflammatory state and insulin resistance can improve after 10 weeks of combined all-extremity high-intensity interval training in sedentary overweight/obese females: a quasi-experimental study

Abstract

Objective

The effects of exercise training on suppression of inflammation have been proposed as a therapeutic approach in recent years to modify the obesity-induced inflammatory status and immunometabolic disorders. The present study aimed to assess the impacts of an all-extremity combined high-intensity interval training (HIIT) on inflammatory state and glycolipid metabolism in young sedentary overweight and obese females.

Method

This was an quasi-experimental study which was applied by comparing two groups. The participants were allocated to two active (AG, n = 15) and inactive (IG, n = 15) groups. The serum level of adiponectin, interleukin (IL)-10, pentraxin 3 (PTX3), and tumor-necrosis factor α (TNFα) was measured in all subjects. Also, glycolipid metabolism was assessed by measuring the fasting lipid profile parameters, glucose, and insulin levels and calculating the homeostasis model assessment of insulin resistance (HOMA2-IR).

Results

Following a 10-week combined all-extremity HIIT in the active subjects, the TNFα, PTX3/IL-10, and TNFα/adiponectin were significantly reduced. However, the absolute levels of adiponectin, IL-10, and PTX3 remained unchanged. Additionally, a significant decrease was found in insulin, LDL, and HOMA2-IR, while insulin sensitivity and HDL levels showed a significant increase in the active group compared to the inactive group.

Conclusions

Our 10-week time-efficient combined all-extremity HIIT promoted an anti-inflammatory state and glycolipid metabolism improvement, suggesting this protocol as a practical therapeutic approach in sedentary obese females.

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Acknowledgements

The authors extended their appreciation to Dr. Hossein Khanahmad for his valuable advice. The support of Mrs. Mohadeseh Toghyani and Mrs. Fahimeh Hosseininasab involved in the Immunology Department of Isfahan University of Medical Science Staff is appreciated as well.

Funding

This study was funded by University of Isfahan, Isfahan, Iran (NO. IR.UI.REC.1396.039).

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Authors

Contributions

All authors contributed to the study conception. N.S., S.M.M., and N.E. designed the study and performed the statistical analysis. N.S, N.E., and M.K. run the laboratory experiments and analyzes. N.S. drafted the initial manuscript and N.E. edited the final manuscript. All authors approved the manuscript.

Corresponding authors

Correspondence to Sayed Mohammad Marandi or Nafiseh Esmaeil.

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Soltani, N., Marandi, S.M., Kazemi, M. et al. Meta-inflammatory state and insulin resistance can improve after 10 weeks of combined all-extremity high-intensity interval training in sedentary overweight/obese females: a quasi-experimental study. J Diabetes Metab Disord 19, 717–726 (2020). https://doi.org/10.1007/s40200-020-00550-z

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Keywords

  • Combined training
  • Meta-inflammation
  • Exercise therapy
  • PTX3
  • Obesity