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Substitution of red meat with soybean but not non- soy legumes improves inflammation in patients with type 2 diabetes; a randomized clinical trial

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Abstract

Background and aims

Several studies have documented that consumption of legumes including soybean is inversely associated with systemic inflammation and oxidative stress. This study was done to assess the effects of soy beans or non-soy legumes consumption on C-reactive protein (CRP) and malondialdehyde (MDA) among Patients with Type 2 Diabetes (T2D).

Methods

75 persons with T2D participated in this randomized controlled clinical trial. Participants were randomized to one of the following 3 groups for 8 weeks: soy bean group (taking a cup of cooked soy beans three days a week), legumes group (taking a cup of cooked non-soy legumes three days a week) and control group (taking two servings of red meat three days a week). Anthropometric indices, dietary intakes, and serum MDA and CRP were measured at baseline and after intervention.

Results

A Significant decrease was observed in serum CRP of soy bean group (P = 0.01) which was significantly more than the controls (p = 0.001), while no significant changes of CRP was observed in legume group. Serum MDA changed significantly in none of the 3 groups.

Conclusions

In conclusion, we found that substitution of red meat with soybean but not non- soy legumes may reduce inflammatory factors with no effects on oxidative stress in diabetic patients.

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Acknowledgements

The authors would like to thank all participants for their kind cooperation. This article was extracted from an MSc thesis written by Zeinab Hemmatdar which was funded by Shiraz University of Medical Sciences with the grant No 94-01-84-9916.

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Authors and Affiliations

  1. Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

    Zeynab Hematdar, Negar Ghasemifard & Shiva Faghih

  2. Department of Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran

    Gholamreza Phishdad

Authors
  1. Zeynab Hematdar
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  2. Negar Ghasemifard
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  3. Gholamreza Phishdad
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  4. Shiva Faghih
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Correspondence to Shiva Faghih.

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The authors declared that they have no conflict of interest.

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Hematdar, Z., Ghasemifard, N., Phishdad, G. et al. Substitution of red meat with soybean but not non- soy legumes improves inflammation in patients with type 2 diabetes; a randomized clinical trial. J Diabetes Metab Disord 17, 111–116 (2018). https://doi.org/10.1007/s40200-018-0346-6

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  • DOI: https://doi.org/10.1007/s40200-018-0346-6

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