Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility

Abstract

Hydroxyapatite (HA) bioceramic scaffolds were fabricated by using digital light processing (DLP) based additive manufacturing. Key issues on the HA bioceramic scaffolds, including dispersion, DLP fabrication, sintering, mechanical properties, and biocompatibility were discussed in detail. Firstly, the effects of dispersant dosage, solid loading, and sintering temperature were studied. The optimal dispersant dosage, solid loading, and sintering temperature were 2 wt%, 50 vol%, and 1250 °C, respectively. Then, the mechanical properties and biocompatibility of the HA bioceramic scaffolds were investigated. The DLP-prepared porous HA bioceramic scaffold was found to exhibit excellent mechanical properties and degradation behavior. From this study, DLP technique shows good potential for manufacturing HA bioceramic scaffolds.

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Acknowledgements

This study is mainly financially supported by the Beijing Natural Science Foundation (2182064) hosted by Prof. Rujie He. Prof. Rujie He also thanks the support from the National Natural Science Foundation of China (51772028). Prof. Min Xia thanks the support from the Fundamental Research Funds for the Central Universities (3052017010). Prof. Xinxin Jin thanks the support from the National Natural Science Foundation of China (51602082). Dr. Keqiang Zhang thanks the support from the Graduate Technology Innovation Project of Beijing Institute of Technology (No. 2019CX10020).

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Correspondence to Rujie He or Chen Xie.

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Feng, C., Zhang, K., He, R. et al. Additive manufacturing of hydroxyapatite bioceramic scaffolds: Dispersion, digital light processing, sintering, mechanical properties, and biocompatibility. J Adv Ceram 9, 360–373 (2020). https://doi.org/10.1007/s40145-020-0375-8

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Keywords

  • additive manufacturing
  • digital light processing
  • vat photopolymerization
  • hydroxyapatite
  • bioceramic scaffold