Skip to main content

Advertisement

Log in

Anesthesia Management During Cardiopulmonary Bypass: Volatile vs. Intravenous Drugs

  • Cardiovascular Anesthesia (J Fassl, Section Editor)
  • Published:
Current Anesthesiology Reports Aims and scope Submit manuscript

Abstract

Anesthetic management during cardiopulmonary bypass (CPB) is challenging in many aspects. Evidence of mortality reduction due to the use of volatile agents during cardiac surgery has led to their increased use in CPB. Partly because of the difficulty to administer volatile agents during CPB, total intravenous anesthesia (TIVA) has become the most popular technique used by cardiac anesthetists throughout this critical period. The aim of this review is to provide an overview of volatile agents’ administration to ensure maintenance of adequate depth of anesthesia during CPB and weighting risks and benefits of this technique compared to TIVA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Nordén I. The influence of anaesthetics on systemic vascular resistance during cardiopulmonary bypass. Scand J Thorac Cardiovasc Surg. 1974;8:81–7.

    Article  Google Scholar 

  2. Landoni G, Rodseth RN, Santini F, et al. Randomized evidence for reduction of perioperative mortality. J Cardiothorac Vasc Anesth. 2012;26:764–72.

    Article  Google Scholar 

  3. De Hert SG, Vander Linden PJ, Cromheecke S, et al. Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology. 2004;101:299–310.

    Article  Google Scholar 

  4. Nussmeier NA, Moskowitz GJ, Weiskopf RB, et al. In vitro anesthetic washin and washout via bubble oxygenators: influence of anesthetic solubility and rates of carrier gas inflow and pump blood flow. Anesth Analg. 1988;67:982–7.

    CAS  PubMed  Google Scholar 

  5. •• McMullan V, Alston RP, Tyrrell J. Volatile anaesthesia during cardiopulmonary bypass. Perfusion. 2015;30(1):6–16. Published in 2015, a complete review of administering and ensuring anesthesia with VAA during CPB.

    Article  CAS  Google Scholar 

  6. Langbein T, Sonntag H, Trapp D, et al. Volatile anaesthetics and the atmosphere: atmospheric life times and atmospheric effects of halothane, enflurane, isoflurane, desflurane and sevoflurane. Br J Anaesth. 1999;82:66–73.

    Article  CAS  Google Scholar 

  7. Yasny JS, White J. Environmental implications of anesthetic gases. Anesth Prog. 2012;59:154–8.

    Article  Google Scholar 

  8. Nigro Neto C, Arnoni R, Rida BS, Landoni G, Tardelli MA. Randomized trial on the effect of sevoflurane on polypropylene membrane oxygenator performance. J Cardiothorac Vasc Anesth. 2013;27(5):903–7.

    Article  Google Scholar 

  9. •• Nigro Neto C, De Simone F, Cassara L, Silva CGS, Cardoso TAAM, Carco F, et al. Tricks, tips, and literature review on the adapted vaporize system to deliver volatile agents during cardiopulmonary bypass. Ann Card Anaesth. 2016;19(2):240–4. A review examining technical aspects of correct adaptation of vaporizers to CPB circuits.

    Article  Google Scholar 

  10. Lim HS, Cho SH, Kim DK, et al. Isoflurane cracks the polycarbonate connector of extra-corporeal circuit: a case report. Korean J Anesth. 2010;58:304–6.

    Article  Google Scholar 

  11. Nigro Neto C, Landoni G, Cassarà L, De Simone F, Zangrillo A, Tardelli MA. Use of volatile anesthetics during cardiopulmonary bypass: a systematic review of adverse events. J Cardiothorac Vasc Anesth. 2014;28(1):84–9.

    Article  CAS  Google Scholar 

  12. Nitzschke R, Wilgusch J, Kersten JF, Trepte CJ, Haas SA, Reuter DA, et al. Changes in sevoflurane plasma concentration with delivery through the oxygenator during on-pump cardiac surgery. Br J Anaesth. 2013;110:957–65.

    Article  CAS  Google Scholar 

  13. •• Landoni G, Pisano A, Lomivorotov V, Alvaro G, Hajjar L, Paternoster G, Nigro Neto C et al: Randomized evidence for reduction of perioperative mortality: an updated consensus process. J Cardiothorac Vasc Anesth. 2016 pii: S1053–0770(16)30281–6. Summary of a web-based international consensus conference comprising clinicians from 61 countries.

  14. •• Likhvantsev VV, Landoni G, Levikov DI, Grebenchikov OA, Skripkin YV, Cherpakov RA. Sevoflurane versus total intravenous anesthesia for isolated coronary artery bypass surgery with cardiopulmonary bypass: a randomized trial. J Cardiothorac Vasc Anesth. 2016;30(5):1221–7. The largest randomized controlled trial comparing VAA and TIVA in cardiac surgery.

    Article  CAS  Google Scholar 

  15. Schmid E, Krajewski S, Bachmann D, Kurz J, Wendel HP, Rosenberger P, et al. The volatile anesthetic sevoflurane inhibits activation of neutrophil granulocytes during simulated extracorporeal circulation. Int Immunopharmacol. 2012;14(2):202–8.

    Article  CAS  Google Scholar 

  16. Medtronic. Medtronic manual. User manual: medtronic affinity fusion oxygenator. 2012.

  17. Boiano JM, Steege AL. Precautionary practices for administering anesthetic gases: a survey of physician anesthesiologists, nurse anesthetists and anesthesiologist assistants. J Occup Environ Hyg. 2016;13(10).

  18. Byhahn C, Wilke HJ, Westphal K. Occupational exposure to volatile anaesthetics epidemiology and approaches to reducing the problem. Mol Diag Ther. 2001;15:197.

    CAS  Google Scholar 

  19. Mierdl S, Byhahn C, Abdel-Rahman U, et al. Occupational exposure to inhalational anaesthetics during cardiac surgery on cardiopulmonary bypass. Ann Thorac Surg. 2003;75:1924–8.

    Article  Google Scholar 

  20. Blokker-Veldhuis MJ, Rutten PM, De Hert SG. Occupational exposure to sevoflurane during cardiopulmonary bypass. Perfusion. 2011;26:383–9.

    Article  CAS  Google Scholar 

  21. • Nigro Neto C, Landoni G, Tardelli MA. A novel anti-pollution filter for volatile agents during cardiopulmonary bypass: preliminary tests. J Cardiothorac Vasc Anesth. 2017. A successful step towards a new scavenging system, proving ex-vivo efficiency of an activated charcoal filter.

  22. Schoen J, Husemann L, Tiemeyer C, et al. Cognitive function after sevoflurane-vs propofol-based anaesthesia for on-pump cardiac surgery: a randomized controlled trial. Br J Anaesth. 2011;106(6):840–50.

    Article  CAS  Google Scholar 

  23. Alston RP, Anes FR, Tierney C, et al. Isoflurane and hypothermic cardiopulmonary bypass: vasodilation without metabolic effects. J Cardiothorac Vasc Anesth. 1992;6:700–4.

    Article  CAS  Google Scholar 

  24. Hausenloy DJ, Boston-Griffiths E, Yellon DM. Cardioprotection during cardiac surgery. Cardiovasc Res. 2012;94:253–65.

    Article  CAS  Google Scholar 

  25. Heusch G. Cardioprotection: chances and challenges of its translation to the clinic. Lancet. 2013;381:166–75.

    Article  Google Scholar 

  26. Hillis LD, Smith PK, Anderson JL, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: Executive Summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2011;124:2610–42.

    Article  Google Scholar 

  27. Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 Guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation. 2007;116:1971–96.

    Article  Google Scholar 

  28. Bantel C, Maze M, Trapp S. Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2009;110(5):986–95.

    Article  CAS  Google Scholar 

  29. Freiermuth D, Mets B, Bolliger D, Reuthebuch O, Doebele T, Scholz M, et al. Sevoflurane and isoflurane—pharmacokinetics, hemodynamic stability, and cardioprotective effects during cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2016;30(6):1494–501.

    Article  CAS  Google Scholar 

  30. Kawamura T, Kadosaki M, Nara N, Kaise A, Suzuki H, Endo S, et al. Effects of sevoflurane on cytokine balance in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2006;20(4):503–8.

    Article  CAS  Google Scholar 

  31. Rödig G, Keyl C, Wiesner G, Philipp A, Hobbhahn J. Effects of sevoflurane and isoflurane on systemic vascular resistance: use of cardiopulmonary bypass as a study model. Br J Anaesth. 1996;76(1):9–12.

    Article  Google Scholar 

  32. • Güçlü ÇY, Ünver S, Aydinli B, Kazanci D, Dilber E, Özgök A. The effect of sevoflurane vs. TIVA on cerebral oxygen saturation during cardiopulmonary bypass—randomized trial. Adv Clin Exp Med. 2014;23(6):919–24. The primary randomized trial comparing the effects of sevoflurane vs TIVA on cerebral protection during CPB.

    Article  Google Scholar 

  33. Smith S, Scarth E, Sasada M. Drugs in anaesthesia and intensive care. 4th ed. Oxford: Oxford University Press; 2011.

    Book  Google Scholar 

  34. Borisov KY, Moroz VV, Grebenchikov OA, et al. Effect of propofol on sevoflurane-induced myocardial preconditioning in the experiment. Gen Reanimatol. 2013;IX:30–5.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Caetano Nigro Neto.

Ethics declarations

Conflict of Interest

Caetano Nigro Neto, Giovanni Landoni, Francisco José Lucena Bezerra, Thiago Maranhão, Carlos Gustavo, and Adriene Stahlschmidt declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

The original version of this article was revised: The original version of this article unfortunately contained a mistake in the Author group section. ‘Thiago Augusto Almeida Maranhão Cardoso’ should be ‘Thiago Augusto Azevedo Maranhão Cardoso.’

This article is part of the Topical Collection on Cardiovascular Anesthesia

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nigro Neto, C., Landoni, G., Bezerra, F.J.L. et al. Anesthesia Management During Cardiopulmonary Bypass: Volatile vs. Intravenous Drugs. Curr Anesthesiol Rep 7, 299–305 (2017). https://doi.org/10.1007/s40140-017-0222-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40140-017-0222-9

Keywords

Navigation