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Pharmacologic Factors: Anaesthetic Agents that May Influence Cancer Outcomes: Local Anaesthetics

  • Cancer Anesthesia (B Riedel, Section Editor)
  • Published:
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Abstract

Molecular pathways linking inflammation and cancer have been demonstrated. Local anaesthetics have been shown to possess anti-inflammatory effects. Recent retrospective studies have shown that the application of regional anaesthesia is associated with a reduced risk of metastasis and improved long-term outcomes. The beneficial effect of regional anaesthesia has been attributed to the reduction of the postoperative stress response. Biomolecular actions like reduction of Src activation and ICAM-1 expression can explain some of these benefits observed in cancer surgery with local or regional anaesthesia techniques.

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Acknowledgments

Dr. Bernhard Riedel wishes to thank Drs. Donal Buggy, Vijaya Gottumukkala and Erica Sloan for their kind assistance in the development of this issue and the reviewing of the article.

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Authors and Affiliations

  1. Department of Anaesthesiology, Balgrist University Hospital Zurich, Forchstrasse 340, 8008, Zurich, Switzerland

    Alain Borgeat & Carl Schick

  2. Department of Anesthesiology, University of Illinois at Chicago College of Medicine, 1740 West Taylor Street, Chicago, IL, 60612, USA

    Gina Votta-Velis

Authors
  1. Alain Borgeat
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  2. Carl Schick
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  3. Gina Votta-Velis
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Correspondence to Alain Borgeat.

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This article is part of the Topical Collection on Cancer Anesthesia.

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Borgeat, A., Schick, C. & Votta-Velis, G. Pharmacologic Factors: Anaesthetic Agents that May Influence Cancer Outcomes: Local Anaesthetics. Curr Anesthesiol Rep 5, 285–290 (2015). https://doi.org/10.1007/s40140-015-0112-y

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