Abstract
Purpose
Overview and perspectives are provided of radiation hazards associated with deep space human missions, such as to Mars.
Recent Findings
Significant associations between radiation dose and effects of principal concern from space radiation (cancer, cardiovascular, CNS) have not yet been detected in astronauts. Therefore, estimates of radiation-induced health consequences from extended deep space missions are based on studies available from radiation-exposed human populations on Earth (e.g., A-bomb survivors) supplemented with data from biological experiments (primarily rodents) using space-type radiations obtained at specialized radiation facilities. This approach (the best available at this time) has large uncertainties, which strongly influence the number of days permitted in deep space.
Summary
Based on current NASA risk limits, the length of time permitted in space may not be sufficient for a human mission to Mars, even with substantial shielding of the spacecraft. Risk mitigation strategies beyond shielding may therefore be required. Research is continuing to advance in these and related fields.
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References
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Risk of radiation carcinogenesis, NASA Human Research Program Evidence Report, April 7, 2016. https://humanresearchroadmap.nasa.gov/Evidence/reports/Cancer.pdf (accessed May 31, 2018).
Risk of cardiovascular disease and other degenerative tissue effects from radiation exposure, NASA Human Research Program Evidence Report, April 6, 2016. https://humanresearchroadmap.nasa.gov/Evidence/reports/Degen.pdf(accessed May 31, 2018).
Risk of acute and late central nervous system effects from radiation exposure, NASA Human Research Program Evidence Report, April 6, 2016. https://humanresearchroadmap.nasa.gov/Evidence/reports/CNS.pdf (accessed May 31, 2018).
Cucinotta FA, Manuel FK, Jones J, Iszard G, Murray J, Djojonegoro B, et al. Space radiation and cataracts in astronauts. Radiat Res. 2001;156:460–6.
Chylack LT, Peterson LE, Feiveson AH, Wear ML, Manuel FK, Tung WH. NASA study of cataract in astronauts (NASCA). Report 1: cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity. Radiat Res. 2009;172:10–20.
Blakely EA, Kleiman NJ, Neriishi K, Chodick G, Chylack LT, Cucinotta FA, et al. Radiation cataractogenesis: epidemiology and biology. Radiat Res. 2010;173:709–17.
George K, Durante M, Wu H, Willingham V, Badhwar G, Cucinotta FA. Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat Res. 2001;156:731–8.
George K, Willingham V, Cucinotta FA. Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome painting. Radiat Res. 2005;164:474–80.
• Cucinotta FA, Kim MY, Chappel LJ, Huff JL. How safe is safe enough? Radiation risk for a human mission to Mars. PLoS One. 2013;8(10):e74988. This paper and references therein describe the methods used by NASA to estimate health risks to astronauts on deep space missions. The paper also provides estimates of “safe days” in space for male and female astronauts.
Straume T, Slaba T, Bhattacharya S, Braby LA. Cosmic-ray interaction data for designing biological experiments in space. Life Sci Space Res. 2017;13:51–9. This paper provides a detailed description of GCR radiation in deep space, comparison with the ISS, and implications for the biological effectiveness of GCR.
La Tessa C, Sivertz M, Chang I, Lowenstein D, Rusek A. Overview of the NASA space radiation laboratory. Life Sci Space Res. 2016;11:18–23.
Singleterry RC, Blattnig SR, Clowdsley MS, Qualls GD, Sandridge CA, Simonsen LC, et al. OLTARIS: on-line tool for the assessment of radiation in space, NASA/TP–2010-216722; 2010.
Cucinotta FA, Kim MY, Chappel LJ. Evaluating shielding approaches to reduce space radiation cancer risk. NASA report: NASA TM-2012-217361; 2012.
Cucinotta FA, Kim MY, Chappel LJ. Space radiation cancer risk projections and uncertainties—2012. NASA report: NASA/TP-2013-217375; 2013.
Simpson JA. Elemental and isotopic composition of the galactic cosmic rays. Ann Rev Nucl Part Sci. 1983;33:323–81.
Blasi P. The origin of galactic cosmic rays. Astron Astrophys Rev. 2013;21:70–158.
Usoskin IG, Bazilevskaya GA, Kovaltsov GA. Solar modulation parameter for cosmic rays since 1936 reconstructed from ground-based neutron monitors and ionization chambers. J Geophys Res. 2011;116 https://doi.org/10.1029/2010JA016105.
Xapsos MA, Barth JL, Stassinopoulos EG, Burke EA, Gee GB. Space environment effects: model for emission of solar protons (ESP)—cumulative and worst case event fluences. NASA Report TP-1999–209763;1999.
Wilson JW, Cucinotta FA, Tai H, Simonsen LC, Shinn JL, Thibeault SA, et al. Galactic and solar cosmic ray shielding in deep space. NASA Technical Paper. 1997:3682.
• Zeitlin C, Hassler DM, Cucinotta FA, Ehresmann B, Wimmer-Schweingruber RF, Brinza DE, et al. Measurements of energetic particle radiation in transit to Mars on the Mars science laboratory. Science. 2013;340:1080–4. This paper provides radiation measurements during flight to Mars. The MSL-RAD detector was onboard the Curiosity Rover launched on November 26, 2011, and landed on Mars on August 6, 2012.
National Council on Radiation Protection and Measurements. Information needed to make radiation protection recommendations for space missions beyond low-earth orbit. Report 153, Bethesda, MD; 2006.
International Commission on Radiological Protection, The 2007 recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Pergamon Press, Oxford; 2007.
National Council on Radiation Protection and Measurements. Ionizing radiation exposure of the population of the United States. Report No. 160, Bethesda, MD; 2009.
Durante M, Cucinotta FA. Heavy ion carcinogenesis and human space exploration. Nature Rev Cancer. 2008;8:465–72. https://doi.org/10.1038/nrc2391.
Straume T. Medical concerns with space radiation and radiobiological effects. In: J. Pelton and F. Allahadi (Eds) Handbook of cosmic hazards and planetary defense, Springer International Publishing, Switzerland. Doi 10.1007/978-3-319-03952-7_4; 2015.
English RA, Benson RE, Bailey JV, Barnes CM. Apollo Experience Report - Protection against radiation. NASA Technical Note TN D-7080, National Aeronautics and Space Administration, Washington DC; 1973.
Adamczyk A, Clowdsley M, Qualls G, Blattnig S, Lee K, Fry D, et al. Full mission astronaut radiation exposure assessments for long duration lunar surface missions. IEEE. https://doi.org/10.1109/AERO.2011.5747250.
Risk of acute radiation syndromes due to solar particle events, NASA Human Research Program Evidence Report, April 6, 2016. https://humanresearchroadmap.nasa.gov/Evidence/reports/Acute.pdf (accessed May 31, 2018).
Cucinotta FA, Durante M. Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol. 2006;7:431–5.
United Nations Scientific Committee on the effects of atomic radiation, effects of ionizing radiation. Report to the general assembly. New York: United Nations; 2006. p. 2006.
National Research Council. Health risks from exposure to low levels of ionizing radiation: BEIR VII, National Academy of Sciences. Washington, DC: National Academy Press; 2006.
Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958–1998. Radiat Res. 2007;168:1–64.
Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, et al. Risk of cancer after low doses of ionizing radiation: retrospective cohort study in 15 countries. BMJ. 2005;331:77–83.
Eisenberg MJ, Afilano J, Lawler PR, Abrahamowicz M, Richard H, Pilote L. Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction. CMAJ. 2011;183(4):430–6. https://doi.org/10.1503/cmaj.100463.
Ichimaru M, Ishimaru T, Belsky JL. Incidence of leukemia in atomic bomb survivors, Hiroshima and Nagasaki 1959-1971 by radiation dose, years after exposure, age and type of leukemia. J Radiat Res. 1978;19:262–82.
United Nations Scientific Committee on the effects of atomic radiation. Sources and effects of ionizing radiation. Report to the general assembly with scientific annexes. New York: United Nations; 2000.
Richardson DB, Wing S, Schroeder J, Schmitz-Feuerhake I, Hoffmann W. Ionizing radiation and chronic lymphocytic leukemia. Env Health Perspectives. 2005;113:1–5.
Vrijheid M, Cardis E, Ashmore P, Auvinen A, Gilbert E, Habib RR, et al. Ionizing radiation and risk of chronic lymphocytic leukemia in the 15-country study of nuclear industry workers. Radiat Res. 2008;170:661–5. https://doi.org/10.1667/RR1443.1.
Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997. Radiat Res. 2003;160:381–407.
Weil MM, Bedford JS, Bielefedt-Ohmann H, Ray FA, Genik PC, Ehrhart EJ, et al. Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon 56Fe ions. Radiat Res. 2009;172:213–9.
Burns F, Yin Y, Garte SJ, Hosselet S. Estimation of risk based on multiple events in radiation carcinogenesis of rat skin. Adv Space Res. 1994;14:507–19.
Dicello JF, Christian A, Cucinotta FA, Gridley DS, Kathirithamby R, Mann J, et al. In vivo mammary tumorigenesis in the Sprague-Dawley rat and microdosimetric correlates. Phys Med Biol. 2004;49:3817–30.
Folley JH, Borges W, Yamawaki T. Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan. Am J Med. 1952;13:311–21.
Tomonaga M. Leukemia in Nagasaki atomic bomb survivors from 1945 through 1959. Bull Org Mond Sante. 1962;26:619–31.
NASA Space flight human-system standard volume 1, revision a: crew health NASA-STD-3001; 2014.
Bureau of Labor Statistics, Census of fatal occupational injuries. United States Department of Labor; 2012. http://www.bls.gov/iif/oshcfoi1.htm
Glanzmann C, Kaufmann P, Jenni R, Hess OM, Huguenin P. Cardiac risk after mediastinal irradiation for Hodgkin’s disease. Radiother Oncol. 1998;46:51–62.
Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol. 2005;6:557–65.
Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, Soda M, et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003. BMJ. 2010;340:b5349. https://doi.org/10.1136/bmj.b5349.
Takahashi I, Abbott RD, Ohshita T, Takahashi T, Ozasa K, Akahoshi M, et al. A prospective follow-up study of the association of radiation exposure with fatal and non-fatal stroke among atomic bomb survivors in Hiroshima and Nagasaki (1980–2003). BMJ. 2012;Open 2:e000654. https://doi.org/10.1136/bmjopen-2011-000654.
Stewart FA. Mechanisms and dose-response relationships for radiation-induced cardiovascular disease. Ann ICRP. 2012;41:72–9.
Stewart FA, Hoving S, Russell NS. Vascular damage as an underlying mechanisms of cardiac and cerebral toxicity in irradiated cancer patients. Radiat Res. 2010;174:865–9.
Lenarczyk M, Su J, Haworth ST, Komorowski R, et al. Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10Gy total body irradiation. Pharmacol Res Perspect. 2015;3(3):e00145.
International Commission on Radiological Protection, Statement on tissue reactions, ICRP report no. ref 4825-3093-1464. Approved by the Commission on April 21, 2011. Ottawa
Trask B. Human cytogenetics: 46 chromosomes, 46 years and counting. Nature Rev. 2002;3:769–78. https://doi.org/10.1038/nrg905.
Belka C, Budach W, Kortmann RD, Bamberg M. Radiation induced CNS toxicity-molecular and cellular mechanisms. Br J Cancer. 2001;85:1233–9.
Yamada M, Kasagi F, Mimori Y, Miyachi T, Ohshita T, Sasaki H. Incidence of dementia among atomic-bomb survivors—radiation effects research foundation adult health study. J Neurol Sci. 2009;281:11–4. https://doi.org/10.1016/j.jns.2009.03.003.
Gondi V, Hermann BP, Mehta MP, Tome F, Tome W. Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Onc Biol Phys. 2013;85:348–54.
Davis CM, Decicco-Skinner KL, Roma PG, Hienz RD. Individual differences in attentional deficits and dopaminergic protein levels following exposure to proton radiation. Radiat Res. 2014;181:258–71.
Rabin BM, Shukitt-Hale B, Carrihill-Knoll K, Gomes SM. Comparison of the effects of partial- or whole-body exposures to 16O particles on cognitive performance in rats. Radiat Res. 2014;181:251–7.
• Parihar VK, Allen B, Tran KK, Macaraeg TG, Che EM, Kwok SF, et al. What happens to your brain on the way to Mars. Sci Adv. 2015:e1400256. This paper presents results from animal experiments exposed to space-relevant radiations and provides a discussion of the implications for CNS risk to astronauts on a mission to Mars
Wyrobek AJ, Britten RA. Individual variations in dose response for spatial memory learning among outbred Wistar rats exposed from 5 to 20 cGy of 56Fe particles. Environ Mol Mutagen. 2016;57:331–40.
Britten RA, Jewell JS, Duncan VD, Davis LK, Hadley MM, Wyrobek AJ. Spatial memory performance of socially mature Wistar rats is impaired after exposure to low (5 cGy) doses of 1 GeV/n 48Ti particles. Radiat Res. 2017;187:60–5. https://doi.org/10.1667/RR14550.1.
Anno GH, Young RW, Bloom RM, Mercier JR. Dose response relationships for acute ionizing-radiation lethality. Health Phys. 2003;84:565–75.
Kennedy AR. Biological effects of space radiation and development of effective countermeasures. Life Sci Space Res. 2014;1:10–43.
MacVittie TJ, Farese AM, Jackson W 3rd. The hematopoietic syndrome of the acute radiation syndrome in rhesus macaques: a systematic review of the lethal dose response relationship. Health Phys. 2015;109:342–66.
S H, Kim MH, McClellan GE, Cucinotta FA. Modeling the acute health effects of astronauts from exposure to large solar particle events. Health Phys. 2009;96(4):465–76. https://doi.org/10.1097/01.HP.0000339020.92837.61.
United Nations Scientific Committee on the effects of atomic radiation, sources and biological effects. 1982 Report to the general assembly. New York: United Nations. p. 1982.
International Commission on Radiological Protection, Non-stochastic effects of ionizing radiation. ICRP Publication 41. Pergamon Press, Oxford; 1984.
National Research Council. Health effects of exposure to low levels of ionizing radiation: BEIR V, National Academy of Sciences, National Academy Press, Washington, DC; 1990.
Straume T, Blattnig S, Zeitlin C. Radiation hazards and the colonization of Mars. In: Levine JS, Schild RE, editors. The human mission to Mars: colonizing the red planet. Cambridge, MA: Cosmology Science Publishers; 2010. p. 803–49.
Russell WL. Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women. Proc Natl Acad Sci U S A. 1977;74:3523–352.
Russell WL, Kelly EM. Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men. Proc Natl Acad Sci U S A. 1982;79:542–4.
Reynolds RJ, Day SM. Mortality among U.S. astronauts from 1980–2009. Aviat Space Environ Med. 2010;81:1024–7.
•• Elgart SR, Little MP, Chappell LJ, Milder CM, Shavers MR, Huff JL, et al. Radiation exposure and mortality from cardiovascular disease and cancer in early NASA astronauts. Nature Sci Rep. 2018; https://doi.org/10.1038/s41598-018-25467-9. This paper provides the latest epidemiological analysis of astronaut data evaluated for associations between radiation dose and mortality from cardiovascular disease or cancer.
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Work performed under the auspices of the Space Biosciences Division, NASA Ames Research Center, Mountain View, CA.
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Straume, T. Space Radiation Effects on Crew During and After Deep Space Missions. Curr Pathobiol Rep 6, 167–175 (2018). https://doi.org/10.1007/s40139-018-0175-9
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DOI: https://doi.org/10.1007/s40139-018-0175-9