Skip to main content

Advertisement

Log in

Necrotizing Soft Tissue Infections

  • Infectious Disease (J Glauser, Section Editor)
  • Published:
Current Emergency and Hospital Medicine Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The review discusses necrotizing soft tissue infections, including clinical manifestations, diagnosis and management.

Recent Findings

There has been an effort towards developing scoring systems to aid in the diagnosis of necrotizing soft tissue infections and this article reviews those in addition to their applicability. These scoring systems should primarily be used to aid in diagnosis and are not effective at ruling out necrotizing infections. Recent reviews regarding optimal antibiotics and IVIG are also discussed.

Summary

Necrotizing soft tissue infections are challenging to diagnosis as they often mimic more benign conditions. A high clinical suspicion should be maintained to diagnose this disease process. Broad-spectrum antibiotics and surgical debridement are required for management. The mortality from these infections is high and patients will often be critically ill. Prompt diagnosis, resuscitation, and definitive therapy are keys to improvements in patient morbidity and mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Kelly EW, Magilner D. Soft tissue infections. In: Tintinalli JE, Stapczynski J, Ma O, Yealy DM, Meckler GD, Cline DM, editors. Tintinalli’s emergency medicine: a comprehensive study guide, 8e. New York, NY: McGraw-Hill; 2016.

    Google Scholar 

  2. Seibert HE, Fernandez A. Necrotizing soft tissue infections. Crit Decis Emerg Med. 2009;23:11.

    Google Scholar 

  3. • Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59:147 Excellent review by the IDSA on the clinical features and treatment of necrotizing infections.

    Article  PubMed  Google Scholar 

  4. •• Bonne SL, Kadri SS. Evaluation and management of necrotizing soft tissue infections. Infect Dis Clin North Am. 2017;31:497 Excellent summary of the microbes that cause necrotizing infections and the pathogenesis.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Frazee BW, Fee C, Lynn J, Wang R, Bostrom A, Hargis C, et al. Community-acquired necrotizing soft tissue infections: a review of 122 cases presenting to a single emergency department over 12 years. J Emerg Med. 2008;34:139–46.

    Article  PubMed  Google Scholar 

  6. Abrahamian FM, Talan DA, Moran GJ. Management of skin and soft-tissue infections in the emergency department. Infect Dis Clin N Am. 2008;22:89–116.

    Article  Google Scholar 

  7. Wong CH, Chang HC, Pasupathy S, et al. Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality. J Bone Joint Surg Am. 2003;85:1454–60.

    Article  PubMed  Google Scholar 

  8. Sarani B, Strong M, Pascual J, Schwab CW. Necrotizing fasciitis: current concepts and review of the literature. J Am Coll Surg. 2009;208:279–88.

    Article  PubMed  Google Scholar 

  9. Cainzos M, Gonzalez-Rodriguez FJ. Necrotizing soft tissue infections. Curr Opin Crit Care. 2007;13:433–9.

    Article  PubMed  Google Scholar 

  10. Das DK, Baker MG, Venugopal K. Increasing incidence of necrotizing fasciitis in New Zealand: a nationwide study over the period 1990 to 2006. J Inf Secur. 2011;63:429.

    Google Scholar 

  11. Stevens DL, Bryant AE. Necrotizing soft-tissue infections. N Engl J Med. 2017;377:2253–65.

    Article  PubMed  Google Scholar 

  12. •• Borschitz T, Schlicht S, Siegel E, Hanke E, von Stebut E. Improvement of a clinical score for necrotizing fasciitis: “pain out of proportion” and high CRP levels aid the diagnosis. PLoS One. 2015;10(7):e0132775. https://doi.org/10.1371/journal.pone.0132775 eCollection 2015. This study improved the PPV of the LRINEC score in identifying necrotizing fasciitis.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Stevens DL. Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. Emerg Infect Dis. 1995;1:69–78.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. •• Bonne SL, Kadri SS. Evaluation and management of necrotizing soft tissue infections. Infect Dis Clin North Am. 2017;31(3):497–511. https://doi.org/10.1016/j.idc.2017.05.011 Review. Recent review of clinical manifestations, and the importance of early antibiotics and identification of this disease process.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Zhao JC, Zhang BR, Shi K, Zhang X, Xie CH, Wang J, et al. Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province. BMC Infect Dis. 2017;17(1):792. https://doi.org/10.1186/s12879-017-2907-6.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gozal D, Ziser A, Shupak A, Ariel A, Melamed Y. Necrotizing fasciitis. Arch Surg. 1986;121:233–5.

    Article  CAS  PubMed  Google Scholar 

  17. Jahnson L, Berggren L, Björsell-Ostling E, et al. Streptococcal myositis. Scand J Infect Dis. 1992;24:661–5.

    Article  CAS  PubMed  Google Scholar 

  18. Adams EM, Gudmundsson S, Yocum DE, Haselby RC, Craig WA, Sundstrom WR. Streptococcal myositis. Arch Intern Med. 1985;145:1020–3.

    Article  CAS  PubMed  Google Scholar 

  19. Yoder EL, Mendez J, Khatib R. Spontaneous gangrenous myositis induced by Streptococcus pyogenes: case report and review of the literature. Rev Infect Dis. 1987;9:382–5.

    Article  CAS  PubMed  Google Scholar 

  20. Defining the group A streptococcal toxic shock syndrome. Rationale and consensus definition. The working group on severe streptococcal infections. JAMA. 1993;269:390.

    Article  Google Scholar 

  21. Anaya DA, Dellinger EP. Necrotizing soft-tissue infection: diagnosis and management. Clin Infect Dis. 2007;44:705.

    Article  CAS  PubMed  Google Scholar 

  22. Hasham S, Matteucci P, Stanley PR, Hart NB. Necrotising fasciitis. BMJ. 2005;330:830–3.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Beaudoin AL, Torso L, Richards K, Said M, van Beneden C, Longenberger A, et al. Invasive group A Streptococcus infections associated with liposuction surgery at outpatient facilities not subject to state or federal regulation. JAMA Intern Med. 2014;174:1136–42.

    Article  PubMed  Google Scholar 

  24. Gupta Y, Chhetry M, Pathak KR, et al. Risk factors for necrotizing fasciitis and its outcome at a tertiary care centre. J Ayub Med Coll Abbottabad. 2016;28:680.

    PubMed  Google Scholar 

  25. Wong CH, Chang HC, Pasupathy S, et al. Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality. J Bone Joint Surg Am. 2003;85-A:1454.

    Article  Google Scholar 

  26. Darenberg J, Luca-Harari B, Jasir A, Sandgren A, Pettersson H, Schalen C, et al. Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden. Clin Infect Dis. 2007;45:450–8.

    Article  CAS  PubMed  Google Scholar 

  27. Anaya DA, McMahon K, Nathens AB, Sullivan SR, Foy H, Bulger E. Predictors of mortality and limb loss in necrotizing soft tissue infections. Arch Surg. 2005;140:151–7; discussion 158.

    Article  PubMed  Google Scholar 

  28. Huang KF, Hung MH, Lin YS, Lu CL, Liu C, Chen CC, et al. Independent predictors of mortality for necrotizing fasciitis: a retrospective analysis in a single institution. J Trauma. 2011;71:467–73.

    Article  PubMed  Google Scholar 

  29. Keeley J, Kaji A, Kim D, Yan H, Putnam BA, Plurad D, et al. Predictors of mortality in necrotizing soft tissue infection. Am Surg. 2014;80(10):989–93.

    PubMed  Google Scholar 

  30. Kaul R, McGeer A, Low DE, et al. Population-based surveillance for group A streptococcal necrotizing fasciitis: clinical features, prognostic indicators, and microbiologic analysis of seventy-seven cases. Ontario group A streptococcal study. Am J Med. 1997;103:18.

    Article  CAS  PubMed  Google Scholar 

  31. Brook I, Frazier EH. Clinical and microbiological features of necrotizing fasciitis. J Clin Microbiol. 1995;33:2382.

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Horn CB, Wesp BM, Fiore NB, Rasane RK, Torres M, Turnbull IR, et al. Fungal infections increase the mortality rate three-fold in necrotizing soft-tissue infections. Surg Infect. 2017;18:793–8.

    Article  Google Scholar 

  33. Bisno AL, Stevens DL. Streptococcal infections of skin and soft tissues. N Engl J Med. 1996;334:240–6.

    Article  CAS  PubMed  Google Scholar 

  34. Stevens DL, Bryant AE, Hackett SP, Chang A, Peer G, Kosanke S, et al. Group A streptococcal bacteremia: the role of tumor necrosis factor in shock and organ failure. J Infect Dis. 1996;173:619–26.

    Article  CAS  PubMed  Google Scholar 

  35. Miller LG, Perdreau-Remington F, Rieg G, Mehdi S, Perlroth J, Bayer AS, et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005;352:1445–53.

    Article  CAS  PubMed  Google Scholar 

  36. Stephens BJ, Lathrop JC, Rice WT, Gruenberg JC. Fournier’s gangrene: historic (1764-1978) versus contemporary (1979-1988) differences in etiology and clinical importance. Am Surg. 1993;59:149.

    CAS  PubMed  Google Scholar 

  37. Stevens DL. Necrotizing fasciitis, gas gangrene, myositis and myonecrosis. In: Cohen J, Powderly WG, editors. Infectious diseases. 2nd ed. St Louis, MO: Elsevier; 2004.

    Google Scholar 

  38. Hau V, Ho CO. Necrotising fasciitis caused by Vibrio vulnificus in the lower limb following exposure to seafood on the hand. Hong Kong Med J. 2011;17:335.

    CAS  PubMed  Google Scholar 

  39. Morgan MS. Diagnosis and management of necrotizing fasciitis: a multiparametric approach. J Hosp Infect. 2010;75:249–57.

    Article  CAS  PubMed  Google Scholar 

  40. Chelsom J, Halstensen A, Haga T, Høiby EA. Necrotising fasciitis due to group A streptococci in western Norway: incidence and clinical features. Lancet. 1994;344:1111–5.

    Article  CAS  PubMed  Google Scholar 

  41. Chan T, Yaghoubian A, Rosig D, et al. Low sensitivity of physical examination findings in necrotizing soft tissue infections is improved with laboratory values: a prospective study. Am J Surg. 2008;196:926–30.

    Article  PubMed  Google Scholar 

  42. • Wong CH, Khin LW, Heng KS, et al. The LRINEC (laboratory risk indicator for necrotizing fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. 2004;32:1535–41 One of the first studies to develop a scoring system to assist with diagnosis of necrotizing fasciitis.

    Article  PubMed  Google Scholar 

  43. •• Fernando SM, Tran A, Cheng W, et al. Necrotizing soft tissue infection: diagnostic accuracy of physical examination, imaging, and LRINEC score: a systematic review and meta-analysis. Ann Surg. 2019;269(1):58–65. https://doi.org/10.1097/SLA.0000000000002774. Excellent review of the LRINEC score, its limitations, and importance of not using it as a tool to rule out necrotizing fasciitis.

  44. Neeki MM, Dong F, Au C, Toy J, Khoshab N, Lee C, et al. Evaluating the laboratory risk Indicator to differentiate cellulitis from necrotizing fasciitis in the emergency department. West J Emerg Med. 2017;18(4):684–9. https://doi.org/10.5811/westjem.2017.3.33607 Epub 2017 May 12.

    Article  PubMed  PubMed Central  Google Scholar 

  45. •• Hansen MB, Rasmussen LS, Svensson M, Chakrakodi B, Bruun T, Madsen MB, et al. Norrby-Teglund A; INFECT study group. Sci Rep. 2017;7:42179. https://doi.org/10.1038/srep42179.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Levine EG, Manders SM. Life-threatening necrotizing fasciitis. Clin Dermatol. 2005;23:144–7.

    Article  PubMed  Google Scholar 

  47. Wysoki MG, Santora TA, Shah RM, Friedman AC. Necrotizing fasciitis: CT characteristics. Radiology. 1997;203:859–63.

    Article  CAS  PubMed  Google Scholar 

  48. Wall DB, Klein SR, Black S, de Virgilio C. A simple model to help distinguish necrotizing fasciitis from nonnecrotizing soft tissue infection. J Am Coll Surg. 2000;191:227–31.

    Article  CAS  PubMed  Google Scholar 

  49. Carbonetti F, Cremona A, Carusi V, Guidi M, Iannicelli E, Di Girolamo M, et al. The role of contrast enhanced computed tomography in the diagnosis of necrotizing fasciitis and comparison with the laboratory risk indicator for necrotizing fasciitis (LRINEC). Radiol Med. 2016;121(2):106–21. https://doi.org/10.1007/s11547-015-0575-4 Epub 2015 Aug 19.

    Article  PubMed  Google Scholar 

  50. Zacharias N, Velmahos GC, Salama A, Alam HB, de Moya M, King DR, et al. Diagnosis of necrotizing soft tissue infections by computed tomography. Arch Surg. 2010;145:452–5.

    Article  PubMed  Google Scholar 

  51. Schmid MR, Kossmann T, Duewell S. Differentiation of necrotizing fasciitis and cellulitis using MR imaging. AJR Am J Roentgenol. 1998;170:615–20.

    Article  CAS  PubMed  Google Scholar 

  52. Yen ZS, Wang HP, Ma HM, Chen SC, Chen WJ. Ultrasonographic screening of clinically-suspected necrotizing fasciitis. Acad Emerg Med. 2002;9:1448–551.

    Article  PubMed  Google Scholar 

  53. Sudarsky LA, Laschinger JC, Coppa GF, Spencer FC. Improved results from a standardized approach in treating patients with necrotizing fasciitis. Ann Surg. 1987;206:661.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Zimbelman J, Palmer A, Todd J. Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection. Pediatr Infect Dis J. 1999;18:1096–100. 113.

    Article  Google Scholar 

  55. Mulla ZD, Leaverton PE, Wiersma ST. Invasive group A streptococcal infections in Florida. South Med J. 2003;96:968–73.

    Article  PubMed  Google Scholar 

  56. Hua C, Bosc R, Sbidian E, De Prost N, Hughes C, Jabre P, et al. Interventions for necrotizing soft tissue infections in adults. Cochrane Database Syst Rev. 2018;5. Art. No.: CD011680. https://doi.org/10.1002/14651858.CD011680.pub2.

  57. George ME, Rueth NM, Skarda DE, et al. Hyperbaric oxygen does not improve outcome in patients with necrotizing soft tissue infection. Surg Infect (Larchmt). 2009;10:21–8.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. Bryan Graham.

Ethics declarations

Conflict of Interest

B. Bryan Graham declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Infectious Disease

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Graham, B.B. Necrotizing Soft Tissue Infections. Curr Emerg Hosp Med Rep 7, 19–25 (2019). https://doi.org/10.1007/s40138-019-00179-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40138-019-00179-0

Keywords

Navigation