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Adipose-Derived Stem Cells in Peripheral Nerve Regeneration

  • Traumatic Brain Injury Surgery (S. Timmons, Section Editor)
  • Published:
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Abstract

Purpose of the Review

Peripheral nerve injuries are common, debilitating, and costly. The human body’s innate regenerative capacity is slow, and nerves are often misguided. The purpose of this article is to review a specific cellular, regenerative engineering technique that holds promise for the treatment of peripheral nerve injuries.

Recent Findings

Over the past several decades, research has focused on the utilization of stem cells for peripheral nerve repair. More recently, stem cells collected from adipose tissue (adipose-derived stem cells or ADSCs) have gained traction due to their relative ease of collection and differentiation potential. Both undifferentiated and Schwann cell-like differentiated ADSCs have been used to seed conduits with variable results.

Summary

Technical and ethical issues surrounding stem cells’ self-expansion potential and genetic makeup exist. Ultimately, randomized control trials and FDA approval will be required before widespread clinical translation in the US is realized.

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Acknowledgements

Dr. Ravnic is supported by a Penn State Department of Surgery Grant and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under BIRCWH award number K12HD055882, “Career Development Program in Women’s Health Research at Penn State.” The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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Authors and Affiliations

  1. Department of Surgery, Penn State University, Hershey, PA, USA

    Ashley N. Leberfinger, Dino J. Ravnic & Srinivas V. Koduru

  2. Department of Neurosurgery, Penn State University, Hershey, PA, USA

    Russell Payne, Elias Rizk & Sprague W. Hazard III

  3. Penn State Hershey Medical Center, Department of Anesthesia, Penn State University, 500 University Drive, Hershey, PA, 17033, USA

    Sprague W. Hazard III

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  1. Ashley N. Leberfinger
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  2. Dino J. Ravnic
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  3. Russell Payne
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  6. Sprague W. Hazard III
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Correspondence to Sprague W. Hazard III.

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This article is part of the Topical Collection on Traumatic Brain Injury Surgery.

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Leberfinger, A.N., Ravnic, D.J., Payne, R. et al. Adipose-Derived Stem Cells in Peripheral Nerve Regeneration. Curr Surg Rep 5, 5 (2017). https://doi.org/10.1007/s40137-017-0169-2

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