Current Ophthalmology Reports

, Volume 6, Issue 3, pp 191–199 | Cite as

Clinical Factors for Early and Late Endothelial Cell Loss After Corneal Transplantation

  • Marianne O. PriceEmail author
  • Jonathan H. Lass
  • Francis W. PriceJr
Cornea (P Hamrah and T Yamaguchi, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cornea


Purpose of Review

To consider the relative importance of factors associated with post-keratoplasty endothelial cell loss.

Recent Findings

Lamellar keratoplasty continues to supplant penetrating keratoplasty. When host endothelium is healthy, retaining it with deep anterior lamellar keratoplasty significantly reduces long-term endothelial cell loss. Endothelial keratoplasty and penetrating keratoplasty differ fundamentally in relative rates of early and late central endothelial cell loss, yet at 10 years, their cumulative cell loss is similarly substantial. The greatest risk factor for post-keratoplasty endothelial decompensation is prior glaucoma filtration surgery, particularly an aqueous shunt. Interestingly, vital dye staining and sophisticated imaging software suggest that the actual viable endothelial cell density of donor corneas is often overestimated by specular microscopy, inflating estimates of early cell loss.


Corneal graft longevity is often determined by endothelial cell survival. Adoption of new surgical techniques has improved graft survival, and new imaging techniques allow more accurate preoperative endothelial cell evaluation.


Penetrating keratoplasty Endothelial keratoplasty Anterior lamellar keratoplasty Endothelial cell loss Specular microscopy Eye bank 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Marianne O. Price
    • 1
    Email author
  • Jonathan H. Lass
    • 2
  • Francis W. PriceJr
    • 3
  1. 1.Cornea Research Foundation of AmericaIndianapolisUSA
  2. 2.University Hospitals Eye InstituteCase Western Reserve UniversityClevelandUSA
  3. 3.Price Vision GroupIndianapolisUSA

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