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Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention in Adolescents and Young Adults

  • Adolescent Medicine (M Goldstein and L Johnson, Section Editors)
  • Published:
Current Pediatrics Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To review the literature about oral pre-exposure prophylaxis (PrEP) for HIV prevention, with specific focus on adolescents.

Recent Findings

Use of PrEP reduces new HIV infections among men who have sex with men, heterosexuals, and people who inject drugs. One combination antiretroviral medication is approved for PrEP in the USA for adults. Limited data suggest that PrEP is safe for use in youth, although declines in adherence to PrEP over time suggest the need for adherence interventions specifically targeting youth. Safety concerns related to PrEP include potential negative impacts on bone density and renal function, as well as potential increases in riskier sexual behaviors. The U.S. Public Health Service has published guidelines for PrEP use in adults.

Summary

Current data suggest that PrEP use is safe in adolescents; however, further research is needed on the potential impact of long-term PrEP use on bone density and kidney function.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Division of Adolescent and Transition Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., MLC 4000, Cincinnati, OH, 45229, USA

    Tanya L. Kowalczyk Mullins & Corinne E. Lehmann

  2. University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA

    Tanya L. Kowalczyk Mullins & Corinne E. Lehmann

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  1. Tanya L. Kowalczyk Mullins
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  2. Corinne E. Lehmann
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Correspondence to Tanya L. Kowalczyk Mullins.

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Mullins, T.L.K., Lehmann, C.E. Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention in Adolescents and Young Adults. Curr Pediatr Rep 6, 114–122 (2018). https://doi.org/10.1007/s40124-018-0163-x

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