While proven to be an effective treatment for cystoid macular edema (CME) and diabetic macular edema, intravitreal steroid implants (IVSI) may cause undesirable side effects, including steroid-related glaucoma or migration into the anterior chamber in the case of iris–lens diaphragm disruption. Here we present a new surgical technique that allows for the easy implantation and subsequent fixation of the fluocinolone acetonide intravitreal implant without the risk of migration as a feasible and possibly reversible approach in the treatment of persistent CME in severely damaged eyes.
In this single-center, prospective off-label, proof of principle, scleral fixation of the fluocinolone implant was performed in two eyes with disrupted anterior–posterior segment border and persistent CME. Both eyes were then followed monthly in accordance to a detailed protocol.
The procedure was overall well tolerated without severe side effects. There was no migration of the implant in the anterior chamber in either eye.
Scleral fixation of the fluocinolone implant proved to be a safe and feasible approach in eyes with persistent CME and disrupted anterior–posterior segment border. This new technique also allows for the possible removal of the implant and may therefore be suitable even for eyes at higher risk for side effects, such as glaucoma.
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No funding or sponsorship was received for this study, or publication of this article. The Rapid Service Fee was funded by the authors themselves.
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
We are grateful to Felicitas Cinkler for her technical assistance and support.
This study was partly presented at the DOC Congress 2018, Nürnberg, Germany, the Floretina Congress 2019, Florence, Italy and at the DOG Congress 2019, Berlin, Germany.
Tina R Herold: Novartis Pharma, Allergan Pharm, Bayer (honoraria). Raffael Liegl: Novartis (honoraria). Siegfried G Priglinger: Novartis Pharma GmbH (advisory boards/honoraria), Pharm Allergan (advisory board/honoraria), Zeiss (advisory boards/honoraria), Bayer (honoraria), Alcon (honoraria), Oxurion (honoraria) and Rayner (honoraria). Armin Wolf: Novartis Pharma GmbH, Bayer, Alimera, Allergan, Oertli (travel cost, honoraria, consulting), Roche and Appellis (ongoing clinical trials). Susanna Koenig and Ahmed Almarzoogi have nothing to delcare.
Compliance with Ethics Guidelines
For this single-center, prospective off-label proof of principle of a new surgical technique, no ethics committee approval was required. The study was however performed in accordance with the Helsinki Declaration of 1964 and its later amendments. The included patients signed written informed consent for this off-label surgical procedure and off-label use of the fluocinolone implant and provided consent to publication of their anonymized data and images.
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Herold, T.R., Liegl, R., Koenig, S. et al. Scleral Fixation of the Fluocinolone Acetonide Implant in Eyes with Severe Iris–Lens Diaphragm Disruption and Recalcitrant CME: The Fluocinolone-Loop-Anchoring Technique (FLAT). Ophthalmol Ther 9, 175–179 (2020). https://doi.org/10.1007/s40123-020-00232-2
- Cystoid macular edema
- Fluocinolone implant
- Iris–lens diaphragm disruption
- Scleral fixation