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Molecular Characterization of Lactobacillus plantarum YML016 with Anti-Diabetic, Anti-Melanogenic and Anti-Viral Efficacy

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Abstract

The present study aimed to characterize a lactic acid bacterium Lactobacillus plantarum YML016 by 16 S rRNA gene sequencing and assessing its pharmacological potential in terms of α-glucosidase and tyrosinase inhibitory effects, as well as anti-viral efficacy against human pathogenic influenza A virus H1N1 using MDCK cell line. As a result, ethanolic extract of L. plantarum YML016 exhibited α-glucosidase and tyrosinase inhibitory activities by 95.83 and 73.59%, respectively in terms of its potent anti-diabetic and anti-melanogenic potential. Moreover, YML016 displayed profound anti-cytopathic effect on MDCK cell line when treated with ethanol extract (100 mg/ml) of YML016, confirming its potent anti-viral efficacy against H1N1 influenza A virus.

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Acknowledgements

This research was supported by the Yeungnam University Research Assistantship (RA) given to Rajib Majumder.

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  1. Vivek K. Bajpai and Rajib Majumder have contributed equally to this work.

Authors and Affiliations

  1. Microbiome Laboratory, Department of Applied Microbiology, Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, Republic of Korea

    Vivek K. Bajpai, Rajib Majumder, Irfan A. Rather, Gyeong-Jun Nam & Yong-Ha Park

  2. Department of Energy and Materials Engineering, Dongguk University, 30 Pildong-ro 1-gil, Seoul, 04620, Republic of Korea

    Vivek K. Bajpai

Authors
  1. Vivek K. Bajpai
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  2. Rajib Majumder
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  3. Irfan A. Rather
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  4. Gyeong-Jun Nam
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  5. Yong-Ha Park
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Correspondence to Yong-Ha Park.

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Bajpai, V.K., Majumder, R., Rather, I.A. et al. Molecular Characterization of Lactobacillus plantarum YML016 with Anti-Diabetic, Anti-Melanogenic and Anti-Viral Efficacy. Natl. Acad. Sci. Lett. 41, 301–305 (2018). https://doi.org/10.1007/s40009-018-0659-5

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  • DOI: https://doi.org/10.1007/s40009-018-0659-5

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